Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121140385> ?p ?o ?g. }
- W3121140385 endingPage "1309" @default.
- W3121140385 startingPage "1309" @default.
- W3121140385 abstract "Recently, generalized modules for membrane antigens (GMMA) technology has been proposed as an alternative approach to traditional glycoconjugate vaccines for O-antigen delivery. Saccharide length is a well-known parameter that can impact the immune response induced by glycoconjugates both in terms of magnitude and quality. However, the criticality of O-antigen length on the immune response induced by GMMA-based vaccines has not been fully elucidated. Here, Shigella and Salmonella GMMA-producing strains were further mutated in order to display homogeneous polysaccharide populations of different sizes on a GMMA surface. Resulting GMMA were compared in mice immunization studies. Athymic nude mice were also used to investigate the involvement of T-cells in the immune response elicited. In contrast with what has been reported for traditional glycoconjugate vaccines and independent of the pathogen and the sugar structural characteristics, O-antigen length did not result in being a critical parameter for GMMA immunogenicity. This work supports the identification of critical quality attributes to optimize GMMA vaccine design and improve vaccine efficacy and gives insights on the nature of the immune response induced by GMMA." @default.
- W3121140385 created "2021-02-01" @default.
- W3121140385 creator A5037758419 @default.
- W3121140385 creator A5054227920 @default.
- W3121140385 creator A5058256966 @default.
- W3121140385 creator A5069619958 @default.
- W3121140385 creator A5078077960 @default.
- W3121140385 creator A5079665880 @default.
- W3121140385 creator A5084772854 @default.
- W3121140385 date "2021-01-28" @default.
- W3121140385 modified "2023-10-01" @default.
- W3121140385 title "Effect of O-Antigen Chain Length Regulation on the Immunogenicity of Shigella and Salmonella Generalized Modules for Membrane Antigens (GMMA)" @default.
- W3121140385 cites W1085173720 @default.
- W3121140385 cites W1553712760 @default.
- W3121140385 cites W1890907209 @default.
- W3121140385 cites W1965127915 @default.
- W3121140385 cites W1977884780 @default.
- W3121140385 cites W1991701295 @default.
- W3121140385 cites W1999572962 @default.
- W3121140385 cites W2011258278 @default.
- W3121140385 cites W2012163392 @default.
- W3121140385 cites W2030446871 @default.
- W3121140385 cites W2039516562 @default.
- W3121140385 cites W2043190672 @default.
- W3121140385 cites W2050057463 @default.
- W3121140385 cites W2068086750 @default.
- W3121140385 cites W2082775759 @default.
- W3121140385 cites W2086679235 @default.
- W3121140385 cites W2116137883 @default.
- W3121140385 cites W2121709106 @default.
- W3121140385 cites W2123256096 @default.
- W3121140385 cites W2131801155 @default.
- W3121140385 cites W2135792697 @default.
- W3121140385 cites W2168045627 @default.
- W3121140385 cites W2172203092 @default.
- W3121140385 cites W2214714481 @default.
- W3121140385 cites W2562954821 @default.
- W3121140385 cites W2587864108 @default.
- W3121140385 cites W2768423820 @default.
- W3121140385 cites W2794571305 @default.
- W3121140385 cites W2889291148 @default.
- W3121140385 cites W2894407277 @default.
- W3121140385 cites W2921255922 @default.
- W3121140385 cites W2944108336 @default.
- W3121140385 cites W2967574244 @default.
- W3121140385 cites W2970715612 @default.
- W3121140385 cites W3014423838 @default.
- W3121140385 cites W3019464573 @default.
- W3121140385 cites W3021842282 @default.
- W3121140385 cites W3026158900 @default.
- W3121140385 cites W3027219640 @default.
- W3121140385 cites W3036292187 @default.
- W3121140385 cites W3084284621 @default.
- W3121140385 cites W3111458768 @default.
- W3121140385 doi "https://doi.org/10.3390/ijms22031309" @default.
- W3121140385 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7865430" @default.
- W3121140385 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33525644" @default.
- W3121140385 hasPublicationYear "2021" @default.
- W3121140385 type Work @default.
- W3121140385 sameAs 3121140385 @default.
- W3121140385 citedByCount "15" @default.
- W3121140385 countsByYear W31211403852021 @default.
- W3121140385 countsByYear W31211403852022 @default.
- W3121140385 countsByYear W31211403852023 @default.
- W3121140385 crossrefType "journal-article" @default.
- W3121140385 hasAuthorship W3121140385A5037758419 @default.
- W3121140385 hasAuthorship W3121140385A5054227920 @default.
- W3121140385 hasAuthorship W3121140385A5058256966 @default.
- W3121140385 hasAuthorship W3121140385A5069619958 @default.
- W3121140385 hasAuthorship W3121140385A5078077960 @default.
- W3121140385 hasAuthorship W3121140385A5079665880 @default.
- W3121140385 hasAuthorship W3121140385A5084772854 @default.
- W3121140385 hasBestOaLocation W31211403851 @default.
- W3121140385 hasConcept C13426554 @default.
- W3121140385 hasConcept C147483822 @default.
- W3121140385 hasConcept C203014093 @default.
- W3121140385 hasConcept C2776986154 @default.
- W3121140385 hasConcept C2780868878 @default.
- W3121140385 hasConcept C2781065037 @default.
- W3121140385 hasConcept C2911111840 @default.
- W3121140385 hasConcept C523546767 @default.
- W3121140385 hasConcept C54355233 @default.
- W3121140385 hasConcept C55493867 @default.
- W3121140385 hasConcept C86803240 @default.
- W3121140385 hasConcept C8891405 @default.
- W3121140385 hasConcept C89423630 @default.
- W3121140385 hasConceptScore W3121140385C13426554 @default.
- W3121140385 hasConceptScore W3121140385C147483822 @default.
- W3121140385 hasConceptScore W3121140385C203014093 @default.
- W3121140385 hasConceptScore W3121140385C2776986154 @default.
- W3121140385 hasConceptScore W3121140385C2780868878 @default.
- W3121140385 hasConceptScore W3121140385C2781065037 @default.
- W3121140385 hasConceptScore W3121140385C2911111840 @default.
- W3121140385 hasConceptScore W3121140385C523546767 @default.
- W3121140385 hasConceptScore W3121140385C54355233 @default.
- W3121140385 hasConceptScore W3121140385C55493867 @default.
- W3121140385 hasConceptScore W3121140385C86803240 @default.
- W3121140385 hasConceptScore W3121140385C8891405 @default.