Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121199581> ?p ?o ?g. }
- W3121199581 abstract "Parkinson's dementia is characterised by changes in perception and thought, and preceded by visual dysfunction, making this a useful surrogate for dementia risk. Structural and functional connectivity changes are seen in humans with Parkinson's disease, but the organisational principles are not known. We used resting-state fMRI and diffusion-weighted imaging to examine changes in structural-functional connectivity coupling in patients with Parkinson's disease, and those at risk of dementia. We identified two organisational gradients to structural-functional connectivity decoupling: anterior-to-posterior and unimodal-to-transmodal, with stronger structural-functional connectivity coupling in anterior, unimodal areas and weakened towards posterior, transmodal regions. Next, we related spatial patterns of decoupling to expression of neurotransmitter receptors. We found that dopaminergic and serotonergic transmission relates to decoupling in Parkinson's overall, but instead, serotonergic, cholinergic and noradrenergic transmission relates to decoupling in patients with visual dysfunction. Our findings provide a framework to explain the specific disorders of consciousness in Parkinson's dementia, and the neurotransmitter systems that underlie these." @default.
- W3121199581 created "2021-02-01" @default.
- W3121199581 creator A5001570471 @default.
- W3121199581 creator A5049914115 @default.
- W3121199581 creator A5050634458 @default.
- W3121199581 creator A5063335320 @default.
- W3121199581 creator A5074881456 @default.
- W3121199581 creator A5077718412 @default.
- W3121199581 date "2021-01-19" @default.
- W3121199581 modified "2023-10-15" @default.
- W3121199581 title "Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson’s disease" @default.
- W3121199581 cites W1845447069 @default.
- W3121199581 cites W1964163952 @default.
- W3121199581 cites W1971579987 @default.
- W3121199581 cites W1972912943 @default.
- W3121199581 cites W1973412793 @default.
- W3121199581 cites W1974590920 @default.
- W3121199581 cites W1974660211 @default.
- W3121199581 cites W1977761644 @default.
- W3121199581 cites W1979596064 @default.
- W3121199581 cites W1984453610 @default.
- W3121199581 cites W1988055799 @default.
- W3121199581 cites W1990388039 @default.
- W3121199581 cites W1992633971 @default.
- W3121199581 cites W1993680472 @default.
- W3121199581 cites W1999223970 @default.
- W3121199581 cites W2001526304 @default.
- W3121199581 cites W2001611992 @default.
- W3121199581 cites W2006554089 @default.
- W3121199581 cites W2011091406 @default.
- W3121199581 cites W2016109926 @default.
- W3121199581 cites W2020044743 @default.
- W3121199581 cites W2024310665 @default.
- W3121199581 cites W2052644075 @default.
- W3121199581 cites W2059084497 @default.
- W3121199581 cites W2064274168 @default.
- W3121199581 cites W2066653668 @default.
- W3121199581 cites W2068606962 @default.
- W3121199581 cites W2069676547 @default.
- W3121199581 cites W2071300176 @default.
- W3121199581 cites W2087543132 @default.
- W3121199581 cites W2087598124 @default.
- W3121199581 cites W2089085990 @default.
- W3121199581 cites W2090260786 @default.
- W3121199581 cites W2094435366 @default.
- W3121199581 cites W2107956652 @default.
- W3121199581 cites W2108896002 @default.
- W3121199581 cites W2117140276 @default.
- W3121199581 cites W2117340355 @default.
- W3121199581 cites W2120357670 @default.
- W3121199581 cites W2130010412 @default.
- W3121199581 cites W2130714999 @default.
- W3121199581 cites W2131055855 @default.
- W3121199581 cites W2133195405 @default.
- W3121199581 cites W2140978740 @default.
- W3121199581 cites W2143991193 @default.
- W3121199581 cites W2145850223 @default.
- W3121199581 cites W2156013560 @default.
- W3121199581 cites W2158625734 @default.
- W3121199581 cites W2159289603 @default.
- W3121199581 cites W2163302580 @default.
- W3121199581 cites W2166281097 @default.
- W3121199581 cites W2177917702 @default.
- W3121199581 cites W2178353191 @default.
- W3121199581 cites W2211147350 @default.
- W3121199581 cites W2216351326 @default.
- W3121199581 cites W2260830658 @default.
- W3121199581 cites W2261968647 @default.
- W3121199581 cites W2277613887 @default.
- W3121199581 cites W2320175522 @default.
- W3121199581 cites W2323845838 @default.
- W3121199581 cites W2347197552 @default.
- W3121199581 cites W2474900144 @default.
- W3121199581 cites W2499800833 @default.
- W3121199581 cites W2516356193 @default.
- W3121199581 cites W2536956629 @default.
- W3121199581 cites W2539192155 @default.
- W3121199581 cites W2550725192 @default.
- W3121199581 cites W2557617319 @default.
- W3121199581 cites W2560225087 @default.
- W3121199581 cites W2577189914 @default.
- W3121199581 cites W2595101472 @default.
- W3121199581 cites W2599637679 @default.
- W3121199581 cites W2720573508 @default.
- W3121199581 cites W2741941708 @default.
- W3121199581 cites W2749718288 @default.
- W3121199581 cites W2753292637 @default.
- W3121199581 cites W2754274802 @default.
- W3121199581 cites W2755454636 @default.
- W3121199581 cites W2756797453 @default.
- W3121199581 cites W2763250088 @default.
- W3121199581 cites W2766921515 @default.
- W3121199581 cites W2767819389 @default.
- W3121199581 cites W2785056817 @default.
- W3121199581 cites W2785901447 @default.
- W3121199581 cites W2786198454 @default.
- W3121199581 cites W2797702265 @default.
- W3121199581 cites W2800141014 @default.
- W3121199581 cites W2805058741 @default.
- W3121199581 cites W2806193904 @default.