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- W3121248696 abstract "Cellular senescence is a state of stable cell cycle arrest that can negatively affect the regenerative capacities of tissues and can contribute to inflammation and the progression of various aging-related diseases. Advances in the in vivo detection of cellular senescence are still crucial to monitor the action of senolytic drugs and to assess the early onset or accumulation of senescent cells. Here, we describe a naphthalimide-styrene-based probe (HeckGal) for the detection of cellular senescence both in vitro and in vivo. HeckGal is hydrolyzed by the increased lysosomal β-galactosidase activity of senescent cells, resulting in fluorescence emission. The probe was validated in vitro using normal human fibroblasts and various cancer cell lines undergoing senescence induced by different stress stimuli. Remarkably, HeckGal was also validated in vivo in an orthotopic breast cancer mouse model treated with senescence-inducing chemotherapy and in a renal fibrosis mouse model. In all cases, HeckGal allowed the unambiguous detection of senescence in vitro as well as in tissues and tumors in vivo. This work is expected to provide a potential technology for senescence detection in aged or damaged tissues." @default.
- W3121248696 created "2021-02-01" @default.
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- W3121248696 date "2021-01-27" @default.
- W3121248696 modified "2023-10-18" @default.
- W3121248696 title "A Two-Photon Probe Based on Naphthalimide-Styrene Fluorophore for the <i>In Vivo</i> Tracking of Cellular Senescence" @default.
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- W3121248696 doi "https://doi.org/10.1021/acs.analchem.0c05447" @default.
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