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- W3121349510 abstract "The major impediments to the implementation of cancer immunotherapies are the sustained immune effect and the targeted delivery of these therapeutics, as they have life-threatening adverse effects. In this work, biomimetic metal-organic frameworks [zeolitic imidazolate frameworks (ZIFs)] are used for the controlled delivery of nivolumab (NV), a monoclonal antibody checkpoint inhibitor that was U.S. Food and Drug Administration-approved back in 2014. The sustained release behavior of NV-ZIF has shown a higher efficacy than the naked NV to activate T cells in hematological malignancies. The system was further modified by coating NV-ZIF with cancer cell membrane to enable tumor-specific targeted delivery while treating solid tumors. We envisage that such a biocompatible and biodegradable immunotherapeutic delivery system may promote the development and the translation of hybrid superstructures into smart and personalized delivery platforms." @default.
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- W3121349510 date "2021-01-22" @default.
- W3121349510 modified "2023-10-16" @default.
- W3121349510 title "Sustained and targeted delivery of checkpoint inhibitors by metal-organic frameworks for cancer immunotherapy" @default.
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- W3121349510 doi "https://doi.org/10.1126/sciadv.abe7174" @default.
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