Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121364493> ?p ?o ?g. }
- W3121364493 abstract "The interdependence between thyroid hormones (THs), namely, thyroxine and triiodothyronine, and immune system is nowadays well-recognized, although not yet fully explored. Synthesis, conversion to a bioactive form, and release of THs in the circulation are events tightly supervised by the hypothalamic–pituitary–thyroid (HPT) axis. Newly synthesized THs induce leukocyte proliferation, migration, release of cytokines, and antibody production, triggering an immune response against either sterile or microbial insults. However, chronic patho-physiological alterations of the immune system, such as infection and inflammation, affect HPT axis and, as a direct consequence, THs mechanism of action. Herein, we revise the bidirectional crosstalk between THs and immune cells, required for the proper immune system feedback response among diverse circumstances. Available circulating THs do traffic in two distinct ways depending on the metabolic condition. Mechanistically, internalized THs form a stable complex with their specific receptors, which, upon direct or indirect binding to DNA, triggers a genomic response by activating transcriptional factors, such as those belonging to the Wnt/β-catenin pathway. Alternatively, THs engage integrin αvβ3 receptor on cell membrane and trigger a non-genomic response, which can also signal to the nucleus. In addition, we highlight THs-dependent inflammasome complex modulation and describe new crucial pathways involved in microRNA regulation by THs, in physiological and patho-physiological conditions, which modify the HPT axis and THs performances. Finally, we focus on the non-thyroidal illness syndrome in which the HPT axis is altered and, in turn, affects circulating levels of active THs as reported in viral infections, particularly in immunocompromised patients infected with human immunodeficiency virus." @default.
- W3121364493 created "2021-02-01" @default.
- W3121364493 creator A5000169021 @default.
- W3121364493 creator A5005283925 @default.
- W3121364493 creator A5014305843 @default.
- W3121364493 creator A5021764629 @default.
- W3121364493 creator A5028660383 @default.
- W3121364493 creator A5038581738 @default.
- W3121364493 creator A5050498088 @default.
- W3121364493 creator A5052205384 @default.
- W3121364493 creator A5052645132 @default.
- W3121364493 creator A5064680897 @default.
- W3121364493 creator A5074412581 @default.
- W3121364493 creator A5075605378 @default.
- W3121364493 date "2021-01-21" @default.
- W3121364493 modified "2023-10-02" @default.
- W3121364493 title "Thyroid Hormones Interaction With Immune Response, Inflammation and Non-thyroidal Illness Syndrome" @default.
- W3121364493 cites W1507573241 @default.
- W3121364493 cites W1522207288 @default.
- W3121364493 cites W1561378718 @default.
- W3121364493 cites W1774685281 @default.
- W3121364493 cites W1804579058 @default.
- W3121364493 cites W1835708830 @default.
- W3121364493 cites W1860160715 @default.
- W3121364493 cites W1864325817 @default.
- W3121364493 cites W1967781384 @default.
- W3121364493 cites W1972202038 @default.
- W3121364493 cites W1976286996 @default.
- W3121364493 cites W1977039417 @default.
- W3121364493 cites W1981589500 @default.
- W3121364493 cites W1983190276 @default.
- W3121364493 cites W1988549309 @default.
- W3121364493 cites W1989551786 @default.
- W3121364493 cites W1990877858 @default.
- W3121364493 cites W1991622554 @default.
- W3121364493 cites W2011124873 @default.
- W3121364493 cites W2017402045 @default.
- W3121364493 cites W2020907262 @default.
- W3121364493 cites W2022349101 @default.
- W3121364493 cites W2022697772 @default.
- W3121364493 cites W2023788656 @default.
- W3121364493 cites W2024638894 @default.
- W3121364493 cites W2027585225 @default.
- W3121364493 cites W2029330897 @default.
- W3121364493 cites W2042922152 @default.
- W3121364493 cites W2048679131 @default.
- W3121364493 cites W2051241287 @default.
- W3121364493 cites W2055348159 @default.
- W3121364493 cites W2057857717 @default.
- W3121364493 cites W2061170810 @default.
- W3121364493 cites W2061399970 @default.
- W3121364493 cites W2070651830 @default.
- W3121364493 cites W2074532062 @default.
- W3121364493 cites W2077995281 @default.
- W3121364493 cites W2083150841 @default.
- W3121364493 cites W2085335902 @default.
- W3121364493 cites W2086540936 @default.
- W3121364493 cites W2088538208 @default.
- W3121364493 cites W2098580669 @default.
- W3121364493 cites W2102610168 @default.
- W3121364493 cites W2108671981 @default.
- W3121364493 cites W2112370458 @default.
- W3121364493 cites W2114397821 @default.
- W3121364493 cites W2120644885 @default.
- W3121364493 cites W2121452730 @default.
- W3121364493 cites W2132822330 @default.
- W3121364493 cites W2134193049 @default.
- W3121364493 cites W2142517633 @default.
- W3121364493 cites W2146851107 @default.
- W3121364493 cites W2147314053 @default.
- W3121364493 cites W2151041036 @default.
- W3121364493 cites W2156876812 @default.
- W3121364493 cites W2165638460 @default.
- W3121364493 cites W2168760648 @default.
- W3121364493 cites W2168853947 @default.
- W3121364493 cites W2170798389 @default.
- W3121364493 cites W2183663489 @default.
- W3121364493 cites W2196253651 @default.
- W3121364493 cites W2254807163 @default.
- W3121364493 cites W2295495663 @default.
- W3121364493 cites W2413222282 @default.
- W3121364493 cites W2504986314 @default.
- W3121364493 cites W2513350637 @default.
- W3121364493 cites W2519148568 @default.
- W3121364493 cites W2522054313 @default.
- W3121364493 cites W2527758749 @default.
- W3121364493 cites W2573595336 @default.
- W3121364493 cites W2588515832 @default.
- W3121364493 cites W2592879615 @default.
- W3121364493 cites W2605773822 @default.
- W3121364493 cites W2738771093 @default.
- W3121364493 cites W2750600575 @default.
- W3121364493 cites W2768096340 @default.
- W3121364493 cites W2776988169 @default.
- W3121364493 cites W2793359584 @default.
- W3121364493 cites W2793901723 @default.
- W3121364493 cites W2796921582 @default.
- W3121364493 cites W2884445384 @default.
- W3121364493 cites W2896887402 @default.
- W3121364493 cites W2904952494 @default.