FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121368045> ?p ?o ?g. }

• W3121368045 endingPage "1045" @default.
• W3121368045 startingPage "1039" @default.
• W3121368045 abstract "Abstract Preterm birth is associated with significant neonatal mortality and morbidity worldwide. Chorioamnionitis, inflammation of the fetal membranes (FMs), is a major risk factor and is characterized by neutrophil infiltration. However, the role of neutrophils at the FMs remains unclear. We recently reported that FMs exposed to bacterial LPS recruited more neutrophils compared with resting FMs and activated them to degranulate and release reactive oxygen species, chemokines/cytokines, and neutrophil extracellular traps. We posit that under resting conditions, neutrophils play a protective surveillance role, whereas during infection/inflammation, they induce FM tissue injury. To test this, human FM explants were exposed to neutrophil conditioned media (CM). We demonstrate that CM from neutrophils exposed to resting FM-CM did not affect FM viability or function. Conversely, CM from neutrophils activated by LPS-stimulated FM-CM significantly increased FM secretion of inflammatory IL-6, IL-8, GRO-α, and the markers of membrane weakening, MMP-9 and PGE2. This FM response was partially mediated by ERK signaling and neutrophil extracellular traps through the activation of the DNA sensor, TLR-9. Thus, neutrophils recruited by FMs during infection can propagate FM inflammation and weakening, acting in a feed-forward mechanism to propagate tissue injury at the maternal–fetal interface, increasing the risk of premature FM rupture and preterm birth in women with intrauterine infection." @default.
• W3121368045 created "2021-02-01" @default.
• W3121368045 creator A5005367112 @default.
• W3121368045 creator A5047310369 @default.
• W3121368045 creator A5073015881 @default.
• W3121368045 date "2021-03-01" @default.
• W3121368045 modified "2023-10-17" @default.
• W3121368045 title "Activated Neutrophils Propagate Fetal Membrane Inflammation and Weakening through ERK and Neutrophil Extracellular Trap–Induced TLR-9 Signaling" @default.
• W3121368045 cites W1967025802 @default.
• W3121368045 cites W1975755498 @default.
• W3121368045 cites W1980363362 @default.
• W3121368045 cites W1982745955 @default.
• W3121368045 cites W1998473024 @default.
• W3121368045 cites W2012033091 @default.
• W3121368045 cites W2021724071 @default.
• W3121368045 cites W2026245311 @default.
• W3121368045 cites W2029133167 @default.
• W3121368045 cites W2030151373 @default.
• W3121368045 cites W2031368992 @default.
• W3121368045 cites W2032227357 @default.
• W3121368045 cites W2038748367 @default.
• W3121368045 cites W2040681266 @default.
• W3121368045 cites W2056199974 @default.
• W3121368045 cites W2066477655 @default.
• W3121368045 cites W2069375519 @default.
• W3121368045 cites W2077666808 @default.
• W3121368045 cites W2093756791 @default.
• W3121368045 cites W2096695199 @default.
• W3121368045 cites W2098482997 @default.
• W3121368045 cites W2104934425 @default.
• W3121368045 cites W2108466048 @default.
• W3121368045 cites W2109730362 @default.
• W3121368045 cites W2112313575 @default.
• W3121368045 cites W2116740515 @default.
• W3121368045 cites W2137379335 @default.
• W3121368045 cites W2139108849 @default.
• W3121368045 cites W2140580102 @default.
• W3121368045 cites W2146858380 @default.
• W3121368045 cites W2154064379 @default.
• W3121368045 cites W2155932634 @default.
• W3121368045 cites W2165751124 @default.
• W3121368045 cites W2171581427 @default.
• W3121368045 cites W2284170594 @default.
• W3121368045 cites W2311115959 @default.
• W3121368045 cites W2565746024 @default.
• W3121368045 cites W2586251728 @default.
• W3121368045 cites W2755164896 @default.
• W3121368045 cites W2790073305 @default.
• W3121368045 cites W2948906372 @default.
• W3121368045 cites W2982600436 @default.
• W3121368045 cites W2994637826 @default.
• W3121368045 cites W2996050108 @default.
• W3121368045 cites W3014194219 @default.
• W3121368045 doi "https://doi.org/10.4049/jimmunol.2001268" @default.
• W3121368045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7889695" @default.
• W3121368045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33472905" @default.
• W3121368045 hasPublicationYear "2021" @default.
• W3121368045 type Work @default.
• W3121368045 sameAs 3121368045 @default.
• W3121368045 citedByCount "6" @default.
• W3121368045 countsByYear W31213680452021 @default.
• W3121368045 countsByYear W31213680452022 @default.
• W3121368045 countsByYear W31213680452023 @default.
• W3121368045 crossrefType "journal-article" @default.
• W3121368045 hasAuthorship W3121368045A5005367112 @default.
• W3121368045 hasAuthorship W3121368045A5047310369 @default.
• W3121368045 hasAuthorship W3121368045A5073015881 @default.
• W3121368045 hasBestOaLocation W31213680451 @default.
• W3121368045 hasConcept C13373296 @default.
• W3121368045 hasConcept C134897094 @default.
• W3121368045 hasConcept C136449434 @default.
• W3121368045 hasConcept C164027704 @default.
• W3121368045 hasConcept C172680121 @default.
• W3121368045 hasConcept C203014093 @default.
• W3121368045 hasConcept C2776914184 @default.
• W3121368045 hasConcept C2777629866 @default.
• W3121368045 hasConcept C2779234561 @default.
• W3121368045 hasConcept C28406088 @default.
• W3121368045 hasConcept C54355233 @default.
• W3121368045 hasConcept C71924100 @default.
• W3121368045 hasConcept C86803240 @default.
• W3121368045 hasConcept C8891405 @default.
• W3121368045 hasConcept C95444343 @default.
• W3121368045 hasConceptScore W3121368045C13373296 @default.
• W3121368045 hasConceptScore W3121368045C134897094 @default.
• W3121368045 hasConceptScore W3121368045C136449434 @default.
• W3121368045 hasConceptScore W3121368045C164027704 @default.
• W3121368045 hasConceptScore W3121368045C172680121 @default.
• W3121368045 hasConceptScore W3121368045C203014093 @default.
• W3121368045 hasConceptScore W3121368045C2776914184 @default.
• W3121368045 hasConceptScore W3121368045C2777629866 @default.
• W3121368045 hasConceptScore W3121368045C2779234561 @default.
• W3121368045 hasConceptScore W3121368045C28406088 @default.
• W3121368045 hasConceptScore W3121368045C54355233 @default.
• W3121368045 hasConceptScore W3121368045C71924100 @default.
• W3121368045 hasConceptScore W3121368045C86803240 @default.
• W3121368045 hasConceptScore W3121368045C8891405 @default.
• W3121368045 hasConceptScore W3121368045C95444343 @default.

• next