Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121376247> ?p ?o ?g. }
- W3121376247 endingPage "108682" @default.
- W3121376247 startingPage "108682" @default.
- W3121376247 abstract "Novel influenza A virus (IAV) strains elicit recall immune responses to conserved epitopes, making them favorable antigenic choices for universal influenza virus vaccines. Evaluating these immunogens requires a thorough understanding of the antigenic sites targeted by the polyclonal antibody (pAb) response, which single-particle electron microscopy (EM) can sensitively detect. In this study, we employ EM polyclonal epitope mapping (EMPEM) to extensively characterize the pAb response to hemagglutinin (HA) after H5N1 immunization in humans. Cross-reactive pAbs originating from memory B cells immediately bound the stem of HA and persisted for more than a year after vaccination. In contrast, de novo pAb responses to multiple sites on the head of HA, targeting previously determined key neutralizing sites on H5 HA, expanded after the second immunization and waned quickly. Thus, EMPEM provides a robust tool for comprehensively tracking the specificity and durability of immune responses elicited by novel universal influenza vaccine candidates." @default.
- W3121376247 created "2021-02-01" @default.
- W3121376247 creator A5025961798 @default.
- W3121376247 creator A5044367270 @default.
- W3121376247 creator A5044912285 @default.
- W3121376247 creator A5051233055 @default.
- W3121376247 creator A5054057438 @default.
- W3121376247 creator A5056136458 @default.
- W3121376247 creator A5061136971 @default.
- W3121376247 creator A5067790213 @default.
- W3121376247 creator A5082695429 @default.
- W3121376247 date "2021-01-01" @default.
- W3121376247 modified "2023-10-06" @default.
- W3121376247 title "Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination" @default.
- W3121376247 cites W1816587284 @default.
- W3121376247 cites W1982842737 @default.
- W3121376247 cites W1993577147 @default.
- W3121376247 cites W2001089308 @default.
- W3121376247 cites W2019447967 @default.
- W3121376247 cites W2028238051 @default.
- W3121376247 cites W2028470175 @default.
- W3121376247 cites W2030278260 @default.
- W3121376247 cites W2035867359 @default.
- W3121376247 cites W2061059781 @default.
- W3121376247 cites W2069124418 @default.
- W3121376247 cites W2074712481 @default.
- W3121376247 cites W2076449818 @default.
- W3121376247 cites W2104234755 @default.
- W3121376247 cites W2114555019 @default.
- W3121376247 cites W2118852506 @default.
- W3121376247 cites W2119819215 @default.
- W3121376247 cites W2123708888 @default.
- W3121376247 cites W2126309815 @default.
- W3121376247 cites W2130737480 @default.
- W3121376247 cites W2131170401 @default.
- W3121376247 cites W2132629607 @default.
- W3121376247 cites W2136951801 @default.
- W3121376247 cites W2144081223 @default.
- W3121376247 cites W2145825913 @default.
- W3121376247 cites W2152617913 @default.
- W3121376247 cites W2154236154 @default.
- W3121376247 cites W2158412800 @default.
- W3121376247 cites W2161661741 @default.
- W3121376247 cites W2161738112 @default.
- W3121376247 cites W2163135112 @default.
- W3121376247 cites W2188526495 @default.
- W3121376247 cites W2525969270 @default.
- W3121376247 cites W2557207823 @default.
- W3121376247 cites W2580666741 @default.
- W3121376247 cites W2587625522 @default.
- W3121376247 cites W2593511418 @default.
- W3121376247 cites W2765838807 @default.
- W3121376247 cites W2790722089 @default.
- W3121376247 cites W2872545267 @default.
- W3121376247 cites W2887331716 @default.
- W3121376247 cites W2894112953 @default.
- W3121376247 cites W2899714098 @default.
- W3121376247 cites W2913172221 @default.
- W3121376247 cites W2919790473 @default.
- W3121376247 cites W2920805814 @default.
- W3121376247 cites W2950967305 @default.
- W3121376247 cites W2970502448 @default.
- W3121376247 cites W2979641742 @default.
- W3121376247 cites W2990179039 @default.
- W3121376247 cites W2994643129 @default.
- W3121376247 cites W3005609359 @default.
- W3121376247 cites W3011701994 @default.
- W3121376247 cites W3035988644 @default.
- W3121376247 cites W3041479707 @default.
- W3121376247 cites W4255125248 @default.
- W3121376247 doi "https://doi.org/10.1016/j.celrep.2020.108682" @default.
- W3121376247 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7888560" @default.
- W3121376247 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33503432" @default.
- W3121376247 hasPublicationYear "2021" @default.
- W3121376247 type Work @default.
- W3121376247 sameAs 3121376247 @default.
- W3121376247 citedByCount "22" @default.
- W3121376247 countsByYear W31213762472021 @default.
- W3121376247 countsByYear W31213762472022 @default.
- W3121376247 countsByYear W31213762472023 @default.
- W3121376247 crossrefType "journal-article" @default.
- W3121376247 hasAuthorship W3121376247A5025961798 @default.
- W3121376247 hasAuthorship W3121376247A5044367270 @default.
- W3121376247 hasAuthorship W3121376247A5044912285 @default.
- W3121376247 hasAuthorship W3121376247A5051233055 @default.
- W3121376247 hasAuthorship W3121376247A5054057438 @default.
- W3121376247 hasAuthorship W3121376247A5056136458 @default.
- W3121376247 hasAuthorship W3121376247A5061136971 @default.
- W3121376247 hasAuthorship W3121376247A5067790213 @default.
- W3121376247 hasAuthorship W3121376247A5082695429 @default.
- W3121376247 hasBestOaLocation W31213762471 @default.
- W3121376247 hasConcept C147483822 @default.
- W3121376247 hasConcept C159047783 @default.
- W3121376247 hasConcept C159654299 @default.
- W3121376247 hasConcept C195616568 @default.
- W3121376247 hasConcept C203014093 @default.
- W3121376247 hasConcept C22070199 @default.
- W3121376247 hasConcept C2522874641 @default.