Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121436877> ?p ?o ?g. }
- W3121436877 endingPage "1201" @default.
- W3121436877 startingPage "1191" @default.
- W3121436877 abstract "Aim To elucidate the impact of liraglutide on the kinetics of apolipoprotein (apo)B48- and apoB100-containing triglyceride-rich lipoproteins in subjects with type 2 diabetes (T2D) after a single fat-rich meal. Materials and Methods Subjects with T2D were included in a study to investigate postprandial apoB48 and apoB100 metabolism before and after 16 weeks on l.8 mg/day liraglutide (n = 14) or placebo (n = 4). Stable isotope tracer and compartmental modelling techniques were used to determine the impact of liraglutide on chylomicron and very low-density lipoprotein (VLDL) production and clearance after a single fat-rich meal. Results Liraglutide reduced apoB48 synthesis in chylomicrons by 60% (p < .0001) and increased the triglyceride/apoB48 ratio (i.e. the size) of chylomicrons (p < .001). Direct clearance of chylomicrons, a quantitatively significant pathway pretreatment, decreased by 90% on liraglutide (p < .001). Liraglutide also reduced VLDL1-triglyceride secretion (p = .017) in parallel with reduced liver fat. Chylomicron-apoB48 production and particle size were related to insulin sensitivity (p = .015 and p < .001, respectively), but these associations were perturbed by liraglutide. Conclusions In a physiologically relevant setting that mirrored regular feeding in subjects with T2D, liraglutide promoted potentially beneficial changes on postprandial apoB48 metabolism. Using our data in an integrated metabolic model, we describe how the action of liraglutide in T2D on chylomicron and VLDL kinetics could lead to decreased generation of remnant lipoproteins." @default.
- W3121436877 created "2021-02-01" @default.
- W3121436877 creator A5002059527 @default.
- W3121436877 creator A5003522491 @default.
- W3121436877 creator A5017528838 @default.
- W3121436877 creator A5028687899 @default.
- W3121436877 creator A5033799557 @default.
- W3121436877 creator A5038951874 @default.
- W3121436877 creator A5046743882 @default.
- W3121436877 creator A5047406315 @default.
- W3121436877 creator A5047549223 @default.
- W3121436877 creator A5048638233 @default.
- W3121436877 creator A5057557099 @default.
- W3121436877 creator A5061873626 @default.
- W3121436877 creator A5063351876 @default.
- W3121436877 creator A5069235693 @default.
- W3121436877 date "2021-03-05" @default.
- W3121436877 modified "2023-10-06" @default.
- W3121436877 title "Effects of liraglutide on the metabolism of triglyceride‐rich lipoproteins in type 2 diabetes" @default.
- W3121436877 cites W1502732154 @default.
- W3121436877 cites W1970920203 @default.
- W3121436877 cites W1985994020 @default.
- W3121436877 cites W2002456808 @default.
- W3121436877 cites W2013067322 @default.
- W3121436877 cites W2020915011 @default.
- W3121436877 cites W2022271042 @default.
- W3121436877 cites W2045945505 @default.
- W3121436877 cites W2051999166 @default.
- W3121436877 cites W2056303106 @default.
- W3121436877 cites W2059234590 @default.
- W3121436877 cites W2086985270 @default.
- W3121436877 cites W2093173756 @default.
- W3121436877 cites W2100377339 @default.
- W3121436877 cites W2105985393 @default.
- W3121436877 cites W2112284378 @default.
- W3121436877 cites W2114797146 @default.
- W3121436877 cites W2117219849 @default.
- W3121436877 cites W2117401455 @default.
- W3121436877 cites W2127826926 @default.
- W3121436877 cites W2132477505 @default.
- W3121436877 cites W2150561315 @default.
- W3121436877 cites W2152978153 @default.
- W3121436877 cites W2195293762 @default.
- W3121436877 cites W2346766699 @default.
- W3121436877 cites W2519510391 @default.
- W3121436877 cites W2606281213 @default.
- W3121436877 cites W2791728731 @default.
- W3121436877 cites W2792260658 @default.
- W3121436877 cites W2795481136 @default.
- W3121436877 cites W2807324205 @default.
- W3121436877 cites W2884610847 @default.
- W3121436877 cites W2885653810 @default.
- W3121436877 cites W2891142526 @default.
- W3121436877 cites W2891231432 @default.
- W3121436877 cites W2894993577 @default.
- W3121436877 cites W2896008418 @default.
- W3121436877 cites W2899043391 @default.
- W3121436877 cites W2908299731 @default.
- W3121436877 cites W2916204077 @default.
- W3121436877 cites W2936770531 @default.
- W3121436877 cites W2965846912 @default.
- W3121436877 cites W2994762437 @default.
- W3121436877 cites W3036179581 @default.
- W3121436877 doi "https://doi.org/10.1111/dom.14328" @default.
- W3121436877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33502078" @default.
- W3121436877 hasPublicationYear "2021" @default.
- W3121436877 type Work @default.
- W3121436877 sameAs 3121436877 @default.
- W3121436877 citedByCount "17" @default.
- W3121436877 countsByYear W31214368772021 @default.
- W3121436877 countsByYear W31214368772022 @default.
- W3121436877 countsByYear W31214368772023 @default.
- W3121436877 crossrefType "journal-article" @default.
- W3121436877 hasAuthorship W3121436877A5002059527 @default.
- W3121436877 hasAuthorship W3121436877A5003522491 @default.
- W3121436877 hasAuthorship W3121436877A5017528838 @default.
- W3121436877 hasAuthorship W3121436877A5028687899 @default.
- W3121436877 hasAuthorship W3121436877A5033799557 @default.
- W3121436877 hasAuthorship W3121436877A5038951874 @default.
- W3121436877 hasAuthorship W3121436877A5046743882 @default.
- W3121436877 hasAuthorship W3121436877A5047406315 @default.
- W3121436877 hasAuthorship W3121436877A5047549223 @default.
- W3121436877 hasAuthorship W3121436877A5048638233 @default.
- W3121436877 hasAuthorship W3121436877A5057557099 @default.
- W3121436877 hasAuthorship W3121436877A5061873626 @default.
- W3121436877 hasAuthorship W3121436877A5063351876 @default.
- W3121436877 hasAuthorship W3121436877A5069235693 @default.
- W3121436877 hasBestOaLocation W31214368772 @default.
- W3121436877 hasConcept C11772777 @default.
- W3121436877 hasConcept C126322002 @default.
- W3121436877 hasConcept C134018914 @default.
- W3121436877 hasConcept C185592680 @default.
- W3121436877 hasConcept C2777180221 @default.
- W3121436877 hasConcept C2778163477 @default.
- W3121436877 hasConcept C2778199505 @default.
- W3121436877 hasConcept C2778913445 @default.
- W3121436877 hasConcept C2780072125 @default.
- W3121436877 hasConcept C2781308992 @default.