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- W3121462013 abstract "Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was detected in Wuhan, China about 1 year ago and caused a pandemic that has been ongoing for about 10 months. Optimal antiviral therapy has not yet been established in the treatment of coronavirus disease 2019 (COVID-19) caused by this virus.Remdesivir is one of the most commonly used antiviral drugs in the treatment of COVID-19 worldwide. Remdesivir, a prodrug, converts to its active phosphate form and inhibits RNA-dependent RNA polymerase that enables the replication of the SARS-CoV-2.1 In vitro studies have demonstrated that remdesivir is a substrate for the cytochrome P450 (CYP450) enzymes CYP3A4, CYP2D6 …" @default.
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- W3121462013 date "2021-01-20" @default.
- W3121462013 modified "2023-10-16" @default.
- W3121462013 title "Is it safe to use remdesivir in combination with a combined p-glycoprotein and CYP3A4 inhibitor?" @default.
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- W3121462013 doi "https://doi.org/10.1136/ejhpharm-2021-002680" @default.
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