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• W3121462192 abstract "<h2>Clinical Practice Points</h2> <ul><li>•Familial history of lung cancer is concerning in the clinical setting and often, germline testing is warranted.</li><li>•Individuals with germline alterations in BRCA1 and BRCA2 have increased susceptibility to hereditary cancers such as breast, ovarian, and prostate cancers.</li><li>•We present a clinical case of a young female patient with a notable germline mutation in BRCA2 gene (BRCA2 S497*), concomitantly diagnosed with widespread non–small cell lung cancer (NSCLC). The patient is currently treated with Pembrolizumab, an anti-PD-1 antibody, and Olaparib, a poly-ADP ribose polymerase (PARP) inhibitor, with positive treatment response.</li><li>•Olaparib has been shown to have potent anti-tumor activity in patients with BRCA-mutated breast cancer and in ovarian cancer. Although there is evidence of Olaparib's effectiveness on lung cancer in the preclinical setting, ongoing investigation is underway to evaluate efficacy and safety of Olaparib alone or in combination with chemotherapy or immunotherapy as a promising therapeutic strategy in patients with NSCLC.</li></ul>" @default.
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• W3121462192 date "2021-09-01" @default.
• W3121462192 modified "2023-10-15" @default.
• W3121462192 title "Therapeutic Potential of Olaparib in Combination With Pembrolizumab in a Young Patient With a Maternally Inherited BRCA2 Germline Variant: A Research Report" @default.
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• W3121462192 doi "https://doi.org/10.1016/j.cllc.2021.01.009" @default.
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