FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121475824> ?p ?o ?g. }

• W3121475824 abstract "Plants have been used as medicinal agents for over a thousand years and have proved to be an important source of many clinical drugs. Several species belonging to the Croton genus (Euphorbiaceace) are employed as traditional medicinal agents in Africa, Asia and South America. The Croton species are popularly used to treat cancer, hypertension, inflammation, rheumatism, bleeding gums, malaria, asthma, syphilitic ulcers, diabetes, pain and ulcers. The Croton genus is rich in alkaloids, flavonoids, triterpenoids, diterpenoids and sesquiterpenoids. Some of the substances that have been isolated from the Croton genus have been evaluated for their biological activities including anti-cancer, anti-hypertensive, anti-inflammatory, anti-malarial, anti-ulcer, anti-viral and anti-microbial effects. The study involved a phytochemical and pharmacological analysis of three Southern African Croton species, C. gratissimus Burchell, C. sylvaticus Hoechst and C. pseudopulchellus Pax which are traditionally used for the treatment of various ailments. Twenty-five diterpenoids, four sesquiterpenoids, six triterpenoids, three phytosterols and two lignan derivatives were isolated from the three plants. The structures of these compounds were determined using FTIR, MS, 1D and 2D NMR studies. Thirteen diterpenoids are reported for the first time, including one cembranoid diterpenoid that possess a new rearranged skeleton. Several of the isolated compounds were screened for cytotoxicity effects against PEO1 and PEO1TaxR (paclitaxel resistant) ovarian cancer cell lines, liver tumour (HUH7 strain) cell line and anti-plasmodial activities against the Plasmodium falciparum (CQS) D10 strain. Compounds CG.3, CG.4, CG.7 and CG.9 displayed moderate cytotoxic effects against the PEOl and PEOlTaxR cell lines. The phytochemical analysis of the three Croton species was also undertaken in order to ascertain the presence of limonoids in the Euphorbiaceae family. This is because limonoids which were thought to be restricted to the Meliaceae, Simaroubaceae and Rutaceae families were reported from the African Croton jatrophoides (Euphorbiaceae). Therefore, the absence of limonoids from the three Croton plants evaluated in this study further raises doubts about the occurrence of limonoids from the Euphorbiaceae family, and about the certainty of identification of the C. jatrophoides Pax that was reported to yield limonoids." @default.
• W3121475824 created "2021-02-01" @default.
• W3121475824 creator A5083864005 @default.
• W3121475824 date "2009-01-01" @default.
• W3121475824 modified "2023-09-23" @default.
• W3121475824 title "The Phytochemistry of Three African Croton Species." @default.
• W3121475824 cites W1969503178 @default.
• W3121475824 cites W1970508597 @default.
• W3121475824 cites W1972450290 @default.
• W3121475824 cites W1972912932 @default.
• W3121475824 cites W2014117923 @default.
• W3121475824 cites W2022559822 @default.
• W3121475824 cites W2028126903 @default.
• W3121475824 cites W2042452686 @default.
• W3121475824 cites W2053573991 @default.
• W3121475824 cites W2054280241 @default.
• W3121475824 cites W2059660905 @default.
• W3121475824 cites W2068939875 @default.
• W3121475824 cites W2080989235 @default.
• W3121475824 cites W2085331116 @default.
• W3121475824 cites W2094661433 @default.
• W3121475824 cites W2103074090 @default.
• W3121475824 cites W2113142659 @default.
• W3121475824 cites W2168013026 @default.
• W3121475824 cites W940375973 @default.
• W3121475824 hasPublicationYear "2009" @default.
• W3121475824 type Work @default.
• W3121475824 sameAs 3121475824 @default.
• W3121475824 citedByCount "0" @default.
• W3121475824 crossrefType "dissertation" @default.
• W3121475824 hasAuthorship W3121475824A5083864005 @default.
• W3121475824 hasConcept C195475562 @default.
• W3121475824 hasConcept C206103511 @default.
• W3121475824 hasConcept C2778261524 @default.
• W3121475824 hasConcept C2779047212 @default.
• W3121475824 hasConcept C44937612 @default.
• W3121475824 hasConcept C523307889 @default.
• W3121475824 hasConcept C55493867 @default.
• W3121475824 hasConcept C556039675 @default.
• W3121475824 hasConcept C59822182 @default.
• W3121475824 hasConcept C71924100 @default.
• W3121475824 hasConcept C86803240 @default.
• W3121475824 hasConceptScore W3121475824C195475562 @default.
• W3121475824 hasConceptScore W3121475824C206103511 @default.
• W3121475824 hasConceptScore W3121475824C2778261524 @default.
• W3121475824 hasConceptScore W3121475824C2779047212 @default.
• W3121475824 hasConceptScore W3121475824C44937612 @default.
• W3121475824 hasConceptScore W3121475824C523307889 @default.
• W3121475824 hasConceptScore W3121475824C55493867 @default.
• W3121475824 hasConceptScore W3121475824C556039675 @default.
• W3121475824 hasConceptScore W3121475824C59822182 @default.
• W3121475824 hasConceptScore W3121475824C71924100 @default.
• W3121475824 hasConceptScore W3121475824C86803240 @default.
• W3121475824 hasLocation W31214758241 @default.
• W3121475824 hasOpenAccess W3121475824 @default.
• W3121475824 hasPrimaryLocation W31214758241 @default.
• W3121475824 hasRelatedWork W1662321770 @default.
• W3121475824 hasRelatedWork W1964127298 @default.
• W3121475824 hasRelatedWork W1983299045 @default.
• W3121475824 hasRelatedWork W2002807243 @default.
• W3121475824 hasRelatedWork W2028835017 @default.
• W3121475824 hasRelatedWork W2035713199 @default.
• W3121475824 hasRelatedWork W2124485866 @default.
• W3121475824 hasRelatedWork W2211250942 @default.
• W3121475824 hasRelatedWork W2381589917 @default.
• W3121475824 hasRelatedWork W2561397857 @default.
• W3121475824 hasRelatedWork W2587387593 @default.
• W3121475824 hasRelatedWork W2613485550 @default.
• W3121475824 hasRelatedWork W2626783403 @default.
• W3121475824 hasRelatedWork W2794126985 @default.
• W3121475824 hasRelatedWork W2887361022 @default.
• W3121475824 hasRelatedWork W2891635249 @default.
• W3121475824 hasRelatedWork W2962462308 @default.
• W3121475824 hasRelatedWork W2976504082 @default.
• W3121475824 hasRelatedWork W3093937150 @default.
• W3121475824 hasRelatedWork W71146745 @default.
• W3121475824 isParatext "false" @default.
• W3121475824 isRetracted "false" @default.
• W3121475824 magId "3121475824" @default.
• W3121475824 workType "dissertation" @default.