Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121554132> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3121554132 endingPage "4297" @default.
- W3121554132 startingPage "4291" @default.
- W3121554132 abstract "Abstract Background The ability to identify lupus patients in high disease activity status (HDAS) without knowledge of the SLEDAI could have application in selection of patients for treatment escalation or enrolment in trials. We sought to generate an algorithm that could calculate via model fitting the presence of HDAS using simple demographic and laboratory values. Methods We examined the association of high disease activity (HDA) with demographic and laboratory parameters using prospectively collected data. An HDA visit is recorded when SLEDAI-2K ≥10. We utilized the use of combinatorial search to find algorithms to build a mathematical model predictive of HDA. Performance of each algorithm was evaluated using multi-class area under the receiver operating characteristic curve and the final model was compared with the naïve Bayes classifier, and analysed using the confusion matrix for accuracy and misclassification rate. Results Data on 286 patients, followed for a median of 5.1 years were studied for a total of 5680 visits. Sixteen laboratory parameters were found to be significantly associated with HDA. A total of 216 algorithms were evaluated and the final algorithm chosen was based on seven pathology measures and three demographic variables. It has an accuracy of 88.6% and misclassification rate of 11.4%. When compared with the naïve Bayes classifier [area under the curve (AUC) = 0.663], our algorithm has a better accuracy with AUC = 0.829. Conclusion This study shows that building an accurate model to calculate HDA using routinely available clinical parameters is feasible. Future studies to independently validate the algorithm will be needed to confirm its predictive performance." @default.
- W3121554132 created "2021-02-01" @default.
- W3121554132 creator A5016142657 @default.
- W3121554132 creator A5021367449 @default.
- W3121554132 creator A5036855659 @default.
- W3121554132 creator A5043055068 @default.
- W3121554132 creator A5043196694 @default.
- W3121554132 creator A5048715081 @default.
- W3121554132 creator A5052697817 @default.
- W3121554132 date "2021-01-26" @default.
- W3121554132 modified "2023-10-13" @default.
- W3121554132 title "Algorithm for calculating high disease activity in SLE" @default.
- W3121554132 cites W1912982817 @default.
- W3121554132 cites W2070527591 @default.
- W3121554132 cites W2159860161 @default.
- W3121554132 cites W2161083732 @default.
- W3121554132 cites W2199189793 @default.
- W3121554132 cites W2597227715 @default.
- W3121554132 cites W2905665749 @default.
- W3121554132 cites W3029756663 @default.
- W3121554132 doi "https://doi.org/10.1093/rheumatology/keab003" @default.
- W3121554132 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33493337" @default.
- W3121554132 hasPublicationYear "2021" @default.
- W3121554132 type Work @default.
- W3121554132 sameAs 3121554132 @default.
- W3121554132 citedByCount "9" @default.
- W3121554132 countsByYear W31215541322021 @default.
- W3121554132 countsByYear W31215541322022 @default.
- W3121554132 countsByYear W31215541322023 @default.
- W3121554132 crossrefType "journal-article" @default.
- W3121554132 hasAuthorship W3121554132A5016142657 @default.
- W3121554132 hasAuthorship W3121554132A5021367449 @default.
- W3121554132 hasAuthorship W3121554132A5036855659 @default.
- W3121554132 hasAuthorship W3121554132A5043055068 @default.
- W3121554132 hasAuthorship W3121554132A5043196694 @default.
- W3121554132 hasAuthorship W3121554132A5048715081 @default.
- W3121554132 hasAuthorship W3121554132A5052697817 @default.
- W3121554132 hasConcept C105795698 @default.
- W3121554132 hasConcept C107673813 @default.
- W3121554132 hasConcept C11171543 @default.
- W3121554132 hasConcept C11413529 @default.
- W3121554132 hasConcept C119857082 @default.
- W3121554132 hasConcept C12267149 @default.
- W3121554132 hasConcept C126322002 @default.
- W3121554132 hasConcept C138602881 @default.
- W3121554132 hasConcept C154945302 @default.
- W3121554132 hasConcept C15744967 @default.
- W3121554132 hasConcept C207201462 @default.
- W3121554132 hasConcept C2781140086 @default.
- W3121554132 hasConcept C3020132585 @default.
- W3121554132 hasConcept C33923547 @default.
- W3121554132 hasConcept C41008148 @default.
- W3121554132 hasConcept C52001869 @default.
- W3121554132 hasConcept C58471807 @default.
- W3121554132 hasConcept C71924100 @default.
- W3121554132 hasConcept C95623464 @default.
- W3121554132 hasConceptScore W3121554132C105795698 @default.
- W3121554132 hasConceptScore W3121554132C107673813 @default.
- W3121554132 hasConceptScore W3121554132C11171543 @default.
- W3121554132 hasConceptScore W3121554132C11413529 @default.
- W3121554132 hasConceptScore W3121554132C119857082 @default.
- W3121554132 hasConceptScore W3121554132C12267149 @default.
- W3121554132 hasConceptScore W3121554132C126322002 @default.
- W3121554132 hasConceptScore W3121554132C138602881 @default.
- W3121554132 hasConceptScore W3121554132C154945302 @default.
- W3121554132 hasConceptScore W3121554132C15744967 @default.
- W3121554132 hasConceptScore W3121554132C207201462 @default.
- W3121554132 hasConceptScore W3121554132C2781140086 @default.
- W3121554132 hasConceptScore W3121554132C3020132585 @default.
- W3121554132 hasConceptScore W3121554132C33923547 @default.
- W3121554132 hasConceptScore W3121554132C41008148 @default.
- W3121554132 hasConceptScore W3121554132C52001869 @default.
- W3121554132 hasConceptScore W3121554132C58471807 @default.
- W3121554132 hasConceptScore W3121554132C71924100 @default.
- W3121554132 hasConceptScore W3121554132C95623464 @default.
- W3121554132 hasFunder F4320307773 @default.
- W3121554132 hasFunder F4320311647 @default.
- W3121554132 hasIssue "9" @default.
- W3121554132 hasLocation W31215541321 @default.
- W3121554132 hasOpenAccess W3121554132 @default.
- W3121554132 hasPrimaryLocation W31215541321 @default.
- W3121554132 hasRelatedWork W1493451373 @default.
- W3121554132 hasRelatedWork W2780177025 @default.
- W3121554132 hasRelatedWork W2911982953 @default.
- W3121554132 hasRelatedWork W2948288905 @default.
- W3121554132 hasRelatedWork W2997277234 @default.
- W3121554132 hasRelatedWork W3112292538 @default.
- W3121554132 hasRelatedWork W3194212141 @default.
- W3121554132 hasRelatedWork W4288333917 @default.
- W3121554132 hasRelatedWork W4321369284 @default.
- W3121554132 hasRelatedWork W4328112711 @default.
- W3121554132 hasVolume "60" @default.
- W3121554132 isParatext "false" @default.
- W3121554132 isRetracted "false" @default.
- W3121554132 magId "3121554132" @default.
- W3121554132 workType "article" @default.