Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121560261> ?p ?o ?g. }
- W3121560261 endingPage "91" @default.
- W3121560261 startingPage "65" @default.
- W3121560261 abstract "Protein localization in endothelial cells is tightly regulated to create distinct signaling domains within their tight spatial restrictions including luminal membranes, abluminal membranes, and interendothelial junctions, as well as caveolae and calcium signaling domains. Protein localization in endothelial cells is also determined in part by the vascular bed, with differences between arteries and veins and between large and small arteries. Specific protein polarity and localization is essential for endothelial cells in responding to various extracellular stimuli. In this review, we examine protein localization in the endothelium of resistance arteries, with occasional references to other vessels for contrast, and how that polarization contributes to endothelial function and ultimately whole organism physiology. We highlight the protein localization on the luminal surface, discussing important physiological receptors and the glycocalyx. The protein polarization to the abluminal membrane is especially unique in small resistance arteries with the presence of the myoendothelial junction, a signaling microdomain that regulates vasodilation, feedback to smooth muscle cells, and ultimately total peripheral resistance. We also discuss the interendothelial junction, where tight junctions, adherens junctions, and gap junctions all convene and regulate endothelial function. Finally, we address planar cell polarity, or axial polarity, and how this is regulated by mechanosensory signals like blood flow." @default.
- W3121560261 created "2021-02-01" @default.
- W3121560261 creator A5026067949 @default.
- W3121560261 creator A5036017969 @default.
- W3121560261 creator A5036315752 @default.
- W3121560261 creator A5046998000 @default.
- W3121560261 date "2021-01-01" @default.
- W3121560261 modified "2023-10-14" @default.
- W3121560261 title "Polarized Proteins in Endothelium and Their Contribution to Function" @default.
- W3121560261 cites W145283009 @default.
- W3121560261 cites W1483690774 @default.
- W3121560261 cites W1486368456 @default.
- W3121560261 cites W1493971026 @default.
- W3121560261 cites W1507386113 @default.
- W3121560261 cites W1519297452 @default.
- W3121560261 cites W1521920687 @default.
- W3121560261 cites W1537851214 @default.
- W3121560261 cites W1546802604 @default.
- W3121560261 cites W1565636600 @default.
- W3121560261 cites W1571495789 @default.
- W3121560261 cites W1608390571 @default.
- W3121560261 cites W1777742992 @default.
- W3121560261 cites W1827569473 @default.
- W3121560261 cites W1846377272 @default.
- W3121560261 cites W1859230596 @default.
- W3121560261 cites W1901042426 @default.
- W3121560261 cites W1911230653 @default.
- W3121560261 cites W1914868353 @default.
- W3121560261 cites W1936770188 @default.
- W3121560261 cites W1963535811 @default.
- W3121560261 cites W1963606923 @default.
- W3121560261 cites W1964222441 @default.
- W3121560261 cites W1965359783 @default.
- W3121560261 cites W1966077116 @default.
- W3121560261 cites W1967168361 @default.
- W3121560261 cites W1967292086 @default.
- W3121560261 cites W1967442933 @default.
- W3121560261 cites W1967801153 @default.
- W3121560261 cites W1971833830 @default.
- W3121560261 cites W1971919440 @default.
- W3121560261 cites W1972775606 @default.
- W3121560261 cites W1973032213 @default.
- W3121560261 cites W1975284499 @default.
- W3121560261 cites W1975459727 @default.
- W3121560261 cites W1975759630 @default.
- W3121560261 cites W1975797917 @default.
- W3121560261 cites W1976931217 @default.
- W3121560261 cites W1976936511 @default.
- W3121560261 cites W1977477833 @default.
- W3121560261 cites W1978387124 @default.
- W3121560261 cites W1978774851 @default.
- W3121560261 cites W1978927149 @default.
- W3121560261 cites W1980085014 @default.
- W3121560261 cites W1980758168 @default.
- W3121560261 cites W1982152757 @default.
- W3121560261 cites W1982836978 @default.
- W3121560261 cites W1983883414 @default.
- W3121560261 cites W1983897833 @default.
- W3121560261 cites W1985608606 @default.
- W3121560261 cites W1985822484 @default.
- W3121560261 cites W1986676916 @default.
- W3121560261 cites W1987584620 @default.
- W3121560261 cites W1989552031 @default.
- W3121560261 cites W1990314841 @default.
- W3121560261 cites W1991312277 @default.
- W3121560261 cites W1991643569 @default.
- W3121560261 cites W1994931711 @default.
- W3121560261 cites W1995068629 @default.
- W3121560261 cites W1996736509 @default.
- W3121560261 cites W1997280392 @default.
- W3121560261 cites W1997590090 @default.
- W3121560261 cites W1998228247 @default.
- W3121560261 cites W1998393115 @default.
- W3121560261 cites W1999383552 @default.
- W3121560261 cites W1999978883 @default.
- W3121560261 cites W2000625547 @default.
- W3121560261 cites W2001222940 @default.
- W3121560261 cites W2001252757 @default.
- W3121560261 cites W2001864920 @default.
- W3121560261 cites W2002018258 @default.
- W3121560261 cites W2002552106 @default.
- W3121560261 cites W2003689912 @default.
- W3121560261 cites W2004351703 @default.
- W3121560261 cites W2004974355 @default.
- W3121560261 cites W2005348762 @default.
- W3121560261 cites W2005496468 @default.
- W3121560261 cites W2006871685 @default.
- W3121560261 cites W2007521843 @default.
- W3121560261 cites W2007530420 @default.
- W3121560261 cites W2007876874 @default.
- W3121560261 cites W2008743229 @default.
- W3121560261 cites W2008917594 @default.
- W3121560261 cites W2009213735 @default.
- W3121560261 cites W2010008626 @default.
- W3121560261 cites W2011090923 @default.
- W3121560261 cites W2011214258 @default.
- W3121560261 cites W2015305787 @default.
- W3121560261 cites W2015547329 @default.