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• W3121612957 abstract "A strong association of pCR (pathological complete response) with disease-free survival or overall survival is clinically desirable. The association of pCR with disease-free survival or overall survival in ER+/HER2−breast cancers following neoadjuvant systemic therapy (NAT) or neoadjuvant endocrine therapy (NET) is relatively low as compared to the other two subtypes of breast cancers, namely triple-negative and HER2+ amplified. On the bright side, a neoadjuvant model offers a potential opportunity to explore the efficacy of novel therapies and the associated genomic alterations, thus providing a rare personalized insight into the tumor’s biology and the tumor cells’ response to the drug. Several decades of research have taught us that the disease’s biology is a critical factor determining the tumor cells’ response to any therapy and hence the final outcome of the disease. Here we propose two scenarios wherein apoptosis can be induced in ER+/HER2− breast cancers expressing wild type TP53 and RB genes following combinations of BCL2 inhibitor, MDM2 inhibitor, and cell-cycle inhibitor. The suggested combinations are contextual and based on the current understanding of the cell signaling in the ER+/HER2− breast cancers. The two combinations of drugs are (1) BCL2 inhibitor plus a cell-cycle inhibitor, which can prime the tumor cells for apoptosis, and (2) BCL2 inhibitor plus an MDM2 inhibitor." @default.
• W3121612957 created "2021-02-01" @default.
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• W3121612957 date "2021-01-26" @default.
• W3121612957 modified "2023-09-30" @default.
• W3121612957 title "Targeted Neoadjuvant Therapies in HR+/HER2−Breast Cancers: Challenges for Improving pCR" @default.
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• W3121612957 doi "https://doi.org/10.3390/cancers13030458" @default.
• W3121612957 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7866155" @default.
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• W3121612957 hasPublicationYear "2021" @default.
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