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- W3121631848 abstract "Following an event damaging the DNA, p53 levels increases inducing cell cycle arrest or apoptosis. JMY protein is a transcription co-factor involved in p53 regulation. After a DNA damage, also JMY levels increase and, as this protein accumulates in the nucleus, it forms a complex with P300 and Strap1 which increases the ability of p53 to induce transcription of proteins triggering apoptosis but not cell cycle. Therefore, Increase levels of JMY “direct” p53 activity toward triggering apoptosis. JMY expression is also linked to increased motility as it downregulates the expression of adhesion molecules of the Cadherin family and induces actin nucleation, making the cell less adhesive and more mobile. According to the scenario this gene can therefore have both a suppressive or a tumour promoting activity." @default.
- W3121631848 created "2021-02-01" @default.
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- W3121631848 date "2018-04-18" @default.
- W3121631848 modified "2023-09-24" @default.
- W3121631848 title "The Role of JMY in p53 Regulation." @default.
- W3121631848 doi "https://doi.org/10.20944/preprints201804.0181.v2" @default.
- W3121631848 hasPublicationYear "2018" @default.
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