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- W3121649907 abstract "Articular cartilage injury is a common disease in the field of orthopedics. Because cartilage has poor self-repairing ability, medical intervention is needed. Using melt electro-writing (MEW) technology, tissue engineering scaffolds with high porosity and high precision can be prepared. However, ordinary materials, especially natural polymer materials, are difficult to print. In this study, gelatin was mixed with poly (lactic-co-glycolic acid) to prepare high-concentration and high-viscosity printer ink, which had good printability and formability. A composite scaffold with full-layer TGF-β1 loading mixed with hydroxyapatite was prepared, and the scaffold was implanted at the cartilage injury site; microfracture surgery was conducted to induce the mesenchyme in the bone marrow. Quality stem cells thereby promoted the repair of damaged cartilage. In summary, this study developed a novel printing method, explored the molding conditions based on MEW printing ink, and constructed a bioactive cartilage repair scaffold. The scaffold can use autologous bone marrow mesenchymal stem cells and induce their differentiation to promote cartilage repair." @default.
- W3121649907 created "2021-02-01" @default.
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- W3121649907 date "2021-07-01" @default.
- W3121649907 modified "2023-10-18" @default.
- W3121649907 title "High-precision, gelatin-based, hybrid, bilayer scaffolds using melt electro-writing to repair cartilage injury" @default.
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- W3121649907 doi "https://doi.org/10.1016/j.bioactmat.2020.12.018" @default.
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