FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121721954> ?p ?o ?g. }

• W3121721954 endingPage "295" @default.
• W3121721954 startingPage "295" @default.
• W3121721954 abstract "Mesenchymal stem cells (MSCs) have been shown to have therapeutic efficacy in different complex pathologies in feline species. This effect is attributed to the secretion of a wide variety of bioactive molecules and extracellular vesicles, such as exosomes, with significant paracrine activity, encompassed under the concept of the secretome. However, at present, the exosomes from feline MSCs have not yet been studied in detail. The objective of this study is to analyze and compare the protein profiles of the secretome as a whole and its exosomal fraction from feline adipose-derived MSCs (fAd-MSCs). For this, Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) and Protein–Protein Interaction Networks Functional Enrichment Analysis (STRING) were utilized. A total of 239 proteins were identified in the secretome, and 228 proteins specific to exosomes were identified, with a total of 133 common proteins. The proteins identified in the secretome were located in the extracellular regions and in the cytoplasm, while the exosomal proteins were located mainly in the membrane, cytoplasm and cytosol. Regarding function, in the secretome, proteins involved in different metabolic pathways, in pathways related to the immune system and the endocrine system and in the processing of proteins in the endoplasmic reticulum predominated. In contrast, proteins specific to exosomes were predominantly associated with endocytosis, cell junctions, platelet activation and other cell signaling pathways. The possible future use of the secretome, or some of its components, such as exosomes, would provide a non-cell-based therapeutic strategy for the treatment of different diseases that would avoid the drawbacks of cell therapy." @default.
• W3121721954 created "2021-02-01" @default.
• W3121721954 creator A5002934621 @default.
• W3121721954 creator A5008116526 @default.
• W3121721954 creator A5061205644 @default.
• W3121721954 creator A5074049411 @default.
• W3121721954 creator A5091663866 @default.
• W3121721954 date "2021-01-24" @default.
• W3121721954 modified "2023-10-16" @default.
• W3121721954 title "Proteomic Analysis of the Secretome and Exosomes of Feline Adipose-Derived Mesenchymal Stem Cells" @default.
• W3121721954 cites W1835941416 @default.
• W3121721954 cites W183967228 @default.
• W3121721954 cites W1925491838 @default.
• W3121721954 cites W1969738372 @default.
• W3121721954 cites W1973242875 @default.
• W3121721954 cites W1976046875 @default.
• W3121721954 cites W1978348555 @default.
• W3121721954 cites W1981660632 @default.
• W3121721954 cites W1982767024 @default.
• W3121721954 cites W1990888143 @default.
• W3121721954 cites W1991316122 @default.
• W3121721954 cites W1996526080 @default.
• W3121721954 cites W2000354005 @default.
• W3121721954 cites W2000624736 @default.
• W3121721954 cites W2004774286 @default.
• W3121721954 cites W2009886463 @default.
• W3121721954 cites W2013394636 @default.
• W3121721954 cites W2020558071 @default.
• W3121721954 cites W2023497842 @default.
• W3121721954 cites W2025371271 @default.
• W3121721954 cites W2033931250 @default.
• W3121721954 cites W2045330908 @default.
• W3121721954 cites W2051479964 @default.
• W3121721954 cites W2053943711 @default.
• W3121721954 cites W2060346337 @default.
• W3121721954 cites W2061501637 @default.
• W3121721954 cites W2078684580 @default.
• W3121721954 cites W2085522770 @default.
• W3121721954 cites W2086518820 @default.
• W3121721954 cites W2109127788 @default.
• W3121721954 cites W2119938413 @default.
• W3121721954 cites W2119939122 @default.
• W3121721954 cites W2124925707 @default.
• W3121721954 cites W2130362099 @default.
• W3121721954 cites W2136850043 @default.
• W3121721954 cites W2138393164 @default.
• W3121721954 cites W2154219172 @default.
• W3121721954 cites W2159401023 @default.
• W3121721954 cites W2161059293 @default.
• W3121721954 cites W2169589032 @default.
• W3121721954 cites W2175410088 @default.
• W3121721954 cites W2201248084 @default.
• W3121721954 cites W2207291742 @default.
• W3121721954 cites W2340306432 @default.
• W3121721954 cites W2356626379 @default.
• W3121721954 cites W2463564939 @default.
• W3121721954 cites W2511962206 @default.
• W3121721954 cites W2553886049 @default.
• W3121721954 cites W2602258022 @default.
• W3121721954 cites W2605484523 @default.
• W3121721954 cites W2624839860 @default.
• W3121721954 cites W2766005561 @default.
• W3121721954 cites W2770270415 @default.
• W3121721954 cites W2783867808 @default.
• W3121721954 cites W2794398904 @default.
• W3121721954 cites W2804807049 @default.
• W3121721954 cites W2857550021 @default.
• W3121721954 cites W2894350370 @default.
• W3121721954 cites W2899249150 @default.
• W3121721954 cites W2900505395 @default.
• W3121721954 cites W2904826083 @default.
• W3121721954 cites W2909175659 @default.
• W3121721954 cites W2921573102 @default.
• W3121721954 cites W2953988433 @default.
• W3121721954 cites W2960843460 @default.
• W3121721954 cites W2965521594 @default.
• W3121721954 cites W2997952475 @default.
• W3121721954 cites W3034564443 @default.
• W3121721954 cites W3096057447 @default.
• W3121721954 cites W3110076250 @default.
• W3121721954 cites W3117468114 @default.
• W3121721954 doi "https://doi.org/10.3390/ani11020295" @default.
• W3121721954 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7912403" @default.
• W3121721954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33498940" @default.
• W3121721954 hasPublicationYear "2021" @default.
• W3121721954 type Work @default.
• W3121721954 sameAs 3121721954 @default.
• W3121721954 citedByCount "5" @default.
• W3121721954 countsByYear W31217219542021 @default.
• W3121721954 countsByYear W31217219542022 @default.
• W3121721954 countsByYear W31217219542023 @default.
• W3121721954 crossrefType "journal-article" @default.
• W3121721954 hasAuthorship W3121721954A5002934621 @default.
• W3121721954 hasAuthorship W3121721954A5008116526 @default.
• W3121721954 hasAuthorship W3121721954A5061205644 @default.
• W3121721954 hasAuthorship W3121721954A5074049411 @default.
• W3121721954 hasAuthorship W3121721954A5091663866 @default.
• W3121721954 hasBestOaLocation W31217219541 @default.

• next