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- W3121778045 abstract "Background: Meningeal cryptococcosis is an opportunistic infection that occurs in HIV-infected patients. The main cause of cryptococcosis in the world is Cryptococcus neoformans, as well as in Indonesia. The clinical outcome of cryptococcosis is influenced by several factors. Reports related to clinical, mycological and laboratory characteristics in AIDS patients with meningeal cryptococcosisare not yet exist in Indonesia. The study aimed to determine the clinicaland mycological laboratory characteristics of AIDS patients with meningeal cryptococcosis in the two hospitals in Jakarta. Methods and materials: The spinal fluid specimens which sent for diagnostic purpose to Parasitology Laboratory, Faculty of Medicine Universitas Indonesia (FMUI) were tested for phenotypic identification. Subsequently, molecular identification was conducted at Westerdijk Fungal Biodiversity Institute, Utrecht, the Netherlands. Results: Out of 55 cryptococcosis patients investigated, the majority was male (n = 48 patients; 87%).The frequency of spinal fluid collection was varies; 27 patients had once, 20 patients twice, six patients three times,and one patient done four and five times lumbal puncture. The main clinical symptoms were headache, followed by fever and vomiting. All isolates of Cryptococcus sp.produced melanin, having four colony phenotypes and two types of mating-type. The majority of colony phenotype was mucoid, followed by smooth, white opaque and wrinkle. Out of nine from 55 patients were infected by mixed colony phenotype of Cryptococcus. The most common mating-typewas α-α, which was relevant with its virulent (n = 33 isolates; 69%). Four of 55 patients were infected by mixed mating-type. The possibility of mixed infection of mating-type and colony phenotype was the patient being infected by a different type of Cryptococcus at the same or different time of infection. Conclusion: Headache was the most clinical symptom. The most common mating-type and colony phenotype were α-α and mucoid. There were a mixed mating-type and colony phenotype infection in one patient." @default.
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- W3121778045 date "2020-12-01" @default.
- W3121778045 modified "2023-09-25" @default.
- W3121778045 title "Clinical and mycologycal characteristics of AIDS patients with meningeal cryptococcosis in Jakarta, Indonesia" @default.
- W3121778045 doi "https://doi.org/10.1016/j.ijid.2020.09.1038" @default.
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