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- W3121800654 abstract "Efficient retrieval of synaptic vesicles (SVs) is crucial to sustain synaptic transmission. PICK1 is a unique PDZ- and BAR-domain-containing protein that regulates the trafficking of postsynaptic glutamate receptors. It is also expressed in presynaptic terminals and is associated with the SVs; however, its role in regulating SV recycling remains unknown. Here we show that PICK1 loss of function selectively slows the kinetics of SV endocytosis in primary hippocampal neurons during high-frequency stimulation. PICK1 knockdown also causes surface stranding and mislocalization of the major SV protein synaptophysin along the axon. A functional PDZ domain of PICK1 and its interaction with the core endocytic protein AP-2 are required for the proper targeting and clustering of synaptophysin. We further show that PICK1, and its interaction with AP-2, are required for efficient SV endocytosis and sustained glutamate release. Our findings therefore identify PICK1 as a key regulator of presynaptic vesicle recycling in central synapses." @default.
- W3121800654 created "2021-02-01" @default.
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- W3121800654 date "2020-01-01" @default.
- W3121800654 modified "2023-10-18" @default.
- W3121800654 title "PICK1 Controls Activity-Dependent Synaptic Vesicle Cargo Retrieval" @default.
- W3121800654 doi "https://doi.org/10.2139/ssrn.3616376" @default.
- W3121800654 hasPublicationYear "2020" @default.
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