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- W3121807966 abstract ": Many indigenous medicinal plants with natural neuroprotective and antioxidant properties have shown to be beneficial in a variety of behavioral disorders such as anxiety disorders. To screen the Ethanolic and aqueous extracts of L.leaf for its antianxiety activity in Swiss Albino mice. : Ethanolic and aqueous extracts of L. leaf [PBEE and PBAE] at doses 100 mg/kg and 200 mg/kg were compared with standard (Diazepam 1mg/kg) and control (distilled water). Six Swiss albino mice (3 each of both sexes) weighing 25-30g were used for each group. Level of anxiety was studied using the behavioural models Elevated Plus Maze [EPM] and Light Dark Arena [LDA]. Phytochemical analysis of the extracts was done and compared. Data was analyzed by one-way ANOVA followed by Tukey Kramer’s multiple comparison test at P = 0.05. The results were represented as Mean ± SEM. : PBEE 100mg/kg has shown significant increase in time spent in open arm and number of entries to open arm when compared with control in EPM model. The same dose was found to be significant for time spent in bright area and number of bright area entries in LDA model. On the other hand the PBAE doses were not significantly different from the control. Preliminary phytochemical screening showed the presence of bioactive component flavonoids in both the extracts, but saponins were absent in aqueous extract. : The ethanolic extract of L. at a dose of 100mg/kg has showed significant antianxiety activity." @default.
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- W3121807966 date "2021-01-15" @default.
- W3121807966 modified "2023-09-25" @default.
- W3121807966 title "Evaluation of antianxiety properties of Piper betle L. leaf extracts on swiss albino mice" @default.
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- W3121807966 doi "https://doi.org/10.18231/j.ijpp.2020.043" @default.
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