Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121896770> ?p ?o ?g. }
- W3121896770 abstract "Abstract Background Hydroxychloroquine has not been associated with improved survival among hospitalized COVID-19 patients in the majority of observational studies and similarly was not identified as an effective prophylaxis following exposure in a prospective randomized trial. We aimed to explore the role of hydroxychloroquine therapy in mildly symptomatic patients diagnosed in the outpatient setting. Methods We examined the association between outpatient hydroxychloroquine exposure and the subsequent progression of disease among mildly symptomatic non-hospitalized patients with documented SARS-CoV-2 infection. The primary outcome assessed was requirement of hospitalization. Data was obtained from a retrospective review of electronic health records within a New Jersey USA multi-hospital network. We compared outcomes in patients who received hydroxychloroquine with those who did not applying a multivariable logistic model with propensity matching. Results Among 1274 outpatients with documented SARS-CoV-2 infection 7.6% were prescribed hydroxychloroquine. In a 1067 patient propensity matched cohort, 21.6% with outpatient exposure to hydroxychloroquine were hospitalized, and 31.4% without exposure were hospitalized. In the primary multivariable logistic regression analysis with propensity matching there was an association between exposure to hydroxychloroquine and a decreased rate of hospitalization from COVID-19 (OR 0.53; 95% CI, 0.29, 0.95). Sensitivity analyses revealed similar associations. QTc prolongation events occurred in 2% of patients prescribed hydroxychloroquine with no reported arrhythmia events among those with data available. Conclusions In this retrospective observational study of SARS-CoV-2 infected non-hospitalized patients hydroxychloroquine exposure was associated with a decreased rate of subsequent hospitalization. Additional exploration of hydroxychloroquine in this mildly symptomatic outpatient population is warranted." @default.
- W3121896770 created "2021-02-01" @default.
- W3121896770 creator A5003073742 @default.
- W3121896770 creator A5004186404 @default.
- W3121896770 creator A5007239934 @default.
- W3121896770 creator A5011797345 @default.
- W3121896770 creator A5013717906 @default.
- W3121896770 creator A5014424194 @default.
- W3121896770 creator A5017772744 @default.
- W3121896770 creator A5019383380 @default.
- W3121896770 creator A5024932292 @default.
- W3121896770 creator A5025036628 @default.
- W3121896770 creator A5030342211 @default.
- W3121896770 creator A5031679802 @default.
- W3121896770 creator A5033513950 @default.
- W3121896770 creator A5033567766 @default.
- W3121896770 creator A5034726937 @default.
- W3121896770 creator A5037793615 @default.
- W3121896770 creator A5043368156 @default.
- W3121896770 creator A5046306389 @default.
- W3121896770 creator A5061924804 @default.
- W3121896770 creator A5063691133 @default.
- W3121896770 creator A5066439728 @default.
- W3121896770 creator A5069022496 @default.
- W3121896770 creator A5086123685 @default.
- W3121896770 creator A5089882481 @default.
- W3121896770 creator A5090941234 @default.
- W3121896770 date "2021-01-14" @default.
- W3121896770 modified "2023-10-14" @default.
- W3121896770 title "Hydroxychloroquine in the treatment of outpatients with mildly symptomatic COVID-19: a multi-center observational study" @default.
- W3121896770 cites W2139577967 @default.
- W3121896770 cites W2155163959 @default.
- W3121896770 cites W2560688864 @default.
- W3121896770 cites W2610356532 @default.
- W3121896770 cites W2732557031 @default.
- W3121896770 cites W3001118548 @default.
- W3121896770 cites W3010930696 @default.
- W3121896770 cites W3014050022 @default.
- W3121896770 cites W3015620943 @default.
- W3121896770 cites W3021915688 @default.
- W3121896770 cites W3023082818 @default.
- W3121896770 cites W3023346879 @default.
- W3121896770 cites W3023911418 @default.
- W3121896770 cites W3025972894 @default.
- W3121896770 cites W3031994092 @default.
- W3121896770 cites W3032373213 @default.
- W3121896770 cites W3038867696 @default.
- W3121896770 cites W3040366309 @default.
- W3121896770 cites W3043308024 @default.
- W3121896770 cites W3043764490 @default.
- W3121896770 cites W3048376209 @default.
- W3121896770 cites W3048601848 @default.
- W3121896770 cites W3081116090 @default.
- W3121896770 cites W3081638099 @default.
- W3121896770 cites W3090017856 @default.
- W3121896770 cites W3092982314 @default.
- W3121896770 cites W3095003608 @default.
- W3121896770 cites W3125865700 @default.
- W3121896770 cites W4210642183 @default.
- W3121896770 doi "https://doi.org/10.1186/s12879-021-05773-w" @default.
- W3121896770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7807228" @default.
- W3121896770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33446136" @default.
- W3121896770 hasPublicationYear "2021" @default.
- W3121896770 type Work @default.
- W3121896770 sameAs 3121896770 @default.
- W3121896770 citedByCount "39" @default.
- W3121896770 countsByYear W31218967702020 @default.
- W3121896770 countsByYear W31218967702021 @default.
- W3121896770 countsByYear W31218967702022 @default.
- W3121896770 countsByYear W31218967702023 @default.
- W3121896770 crossrefType "journal-article" @default.
- W3121896770 hasAuthorship W3121896770A5003073742 @default.
- W3121896770 hasAuthorship W3121896770A5004186404 @default.
- W3121896770 hasAuthorship W3121896770A5007239934 @default.
- W3121896770 hasAuthorship W3121896770A5011797345 @default.
- W3121896770 hasAuthorship W3121896770A5013717906 @default.
- W3121896770 hasAuthorship W3121896770A5014424194 @default.
- W3121896770 hasAuthorship W3121896770A5017772744 @default.
- W3121896770 hasAuthorship W3121896770A5019383380 @default.
- W3121896770 hasAuthorship W3121896770A5024932292 @default.
- W3121896770 hasAuthorship W3121896770A5025036628 @default.
- W3121896770 hasAuthorship W3121896770A5030342211 @default.
- W3121896770 hasAuthorship W3121896770A5031679802 @default.
- W3121896770 hasAuthorship W3121896770A5033513950 @default.
- W3121896770 hasAuthorship W3121896770A5033567766 @default.
- W3121896770 hasAuthorship W3121896770A5034726937 @default.
- W3121896770 hasAuthorship W3121896770A5037793615 @default.
- W3121896770 hasAuthorship W3121896770A5043368156 @default.
- W3121896770 hasAuthorship W3121896770A5046306389 @default.
- W3121896770 hasAuthorship W3121896770A5061924804 @default.
- W3121896770 hasAuthorship W3121896770A5063691133 @default.
- W3121896770 hasAuthorship W3121896770A5066439728 @default.
- W3121896770 hasAuthorship W3121896770A5069022496 @default.
- W3121896770 hasAuthorship W3121896770A5086123685 @default.
- W3121896770 hasAuthorship W3121896770A5089882481 @default.
- W3121896770 hasAuthorship W3121896770A5090941234 @default.
- W3121896770 hasBestOaLocation W31218967701 @default.
- W3121896770 hasConcept C126322002 @default.
- W3121896770 hasConcept C151956035 @default.
- W3121896770 hasConcept C167135981 @default.