FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121965677> ?p ?o ?g. }

• W3121965677 endingPage "261" @default.
• W3121965677 startingPage "247" @default.
• W3121965677 abstract "Millions of people die from liver diseases annually, and liver failure is one of the three major outcomes of liver disease. The gut microbiota plays a crucial role in liver diseases. This study aimed to explore the effects of Lactobacillus casei strain Shirota (LcS), a probiotics used widely around the world, on acute liver injury (ALI), as well as the underlying mechanism. Sprague Dawley rats were intragastrically administered LcS suspensions or placebo once daily for 7 days before induction of ALI by intraperitoneal injection of D-galactosamine (D-GalN). Histopathological examination and assessments of liver biochemical markers, inflammatory cytokines, and the gut microbiota, metabolome and transcriptome were conducted. Our results showed that pretreatment with LcS reduced hepatic and intestinal damage and reduced the elevation of serum gamma-glutamyltranspeptidase (GGT), total bile acids, IL-5, IL-10, G-CSF and RANTES. The analysis of the gut microbiota, metabolome and transcriptome showed that LcS lowered the ratio of Firmicutes to Bacteroidetes; reduced the enrichment of metabolites such as chenodeoxycholic acid, deoxycholic acid, lithocholic acid, d-talose and N-acetyl-glucosamine, reduce the depletion of d-glucose and l-methionine; and alleviated the downregulation of retinol metabolism and PPAR signalling and the upregulation of the pyruvate metabolism pathway in the liver. These results indicate the promising prospect of using LcS for the treatment of liver diseases, particularly ALI." @default.
• W3121965677 created "2021-02-01" @default.
• W3121965677 creator A5022175957 @default.
• W3121965677 creator A5023643782 @default.
• W3121965677 creator A5035561786 @default.
• W3121965677 creator A5036925125 @default.
• W3121965677 creator A5040937372 @default.
• W3121965677 creator A5046354867 @default.
• W3121965677 creator A5054987593 @default.
• W3121965677 creator A5056450584 @default.
• W3121965677 creator A5057422995 @default.
• W3121965677 creator A5077616953 @default.
• W3121965677 creator A5086674033 @default.
• W3121965677 creator A5089091664 @default.
• W3121965677 date "2021-01-25" @default.
• W3121965677 modified "2023-10-15" @default.
• W3121965677 title "Probiotic <i>Lactobacillus casei</i> Shirota prevents acute liver injury by reshaping the gut microbiota to alleviate excessive inflammation and metabolic disorders" @default.
• W3121965677 cites W1726014254 @default.
• W3121965677 cites W1994210536 @default.
• W3121965677 cites W1999463160 @default.
• W3121965677 cites W2048306733 @default.
• W3121965677 cites W2049506766 @default.
• W3121965677 cites W2055762878 @default.
• W3121965677 cites W2057844433 @default.
• W3121965677 cites W2059699981 @default.
• W3121965677 cites W2083270615 @default.
• W3121965677 cites W2083994557 @default.
• W3121965677 cites W2089749987 @default.
• W3121965677 cites W2104249477 @default.
• W3121965677 cites W2115956200 @default.
• W3121965677 cites W2118790021 @default.
• W3121965677 cites W2139745186 @default.
• W3121965677 cites W2155391879 @default.
• W3121965677 cites W2169541058 @default.
• W3121965677 cites W2178038387 @default.
• W3121965677 cites W2343917624 @default.
• W3121965677 cites W2428595929 @default.
• W3121965677 cites W2460141262 @default.
• W3121965677 cites W2462265698 @default.
• W3121965677 cites W2504753658 @default.
• W3121965677 cites W2521120605 @default.
• W3121965677 cites W2548552274 @default.
• W3121965677 cites W2558858064 @default.
• W3121965677 cites W2609196293 @default.
• W3121965677 cites W2730062641 @default.
• W3121965677 cites W2738600621 @default.
• W3121965677 cites W2752395352 @default.
• W3121965677 cites W2766292741 @default.
• W3121965677 cites W2807652679 @default.
• W3121965677 cites W2888072686 @default.
• W3121965677 cites W2889566041 @default.
• W3121965677 cites W2894859306 @default.
• W3121965677 cites W2895834165 @default.
• W3121965677 cites W2898288127 @default.
• W3121965677 cites W2904431925 @default.
• W3121965677 cites W2910282186 @default.
• W3121965677 cites W2928665623 @default.
• W3121965677 cites W2946809764 @default.
• W3121965677 cites W2949785434 @default.
• W3121965677 cites W2954693066 @default.
• W3121965677 cites W2955554774 @default.
• W3121965677 cites W2986513759 @default.
• W3121965677 cites W3018579981 @default.
• W3121965677 cites W3042060371 @default.
• W3121965677 cites W3102105088 @default.
• W3121965677 cites W4211175126 @default.
• W3121965677 cites W958079127 @default.
• W3121965677 doi "https://doi.org/10.1111/1751-7915.13750" @default.
• W3121965677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33492728" @default.
• W3121965677 hasPublicationYear "2021" @default.
• W3121965677 type Work @default.
• W3121965677 sameAs 3121965677 @default.
• W3121965677 citedByCount "27" @default.
• W3121965677 countsByYear W31219656772021 @default.
• W3121965677 countsByYear W31219656772022 @default.
• W3121965677 countsByYear W31219656772023 @default.
• W3121965677 crossrefType "journal-article" @default.
• W3121965677 hasAuthorship W3121965677A5022175957 @default.
• W3121965677 hasAuthorship W3121965677A5023643782 @default.
• W3121965677 hasAuthorship W3121965677A5035561786 @default.
• W3121965677 hasAuthorship W3121965677A5036925125 @default.
• W3121965677 hasAuthorship W3121965677A5040937372 @default.
• W3121965677 hasAuthorship W3121965677A5046354867 @default.
• W3121965677 hasAuthorship W3121965677A5054987593 @default.
• W3121965677 hasAuthorship W3121965677A5056450584 @default.
• W3121965677 hasAuthorship W3121965677A5057422995 @default.
• W3121965677 hasAuthorship W3121965677A5077616953 @default.
• W3121965677 hasAuthorship W3121965677A5086674033 @default.
• W3121965677 hasAuthorship W3121965677A5089091664 @default.
• W3121965677 hasBestOaLocation W31219656771 @default.
• W3121965677 hasConcept C100544194 @default.
• W3121965677 hasConcept C104317684 @default.
• W3121965677 hasConcept C126322002 @default.
• W3121965677 hasConcept C127561419 @default.
• W3121965677 hasConcept C135870905 @default.
• W3121965677 hasConcept C2776637226 @default.
• W3121965677 hasConcept C2776662696 @default.
• W3121965677 hasConcept C2777477808 @default.

• next