FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121991679> ?p ?o ?g. }

• W3121991679 endingPage "77" @default.
• W3121991679 startingPage "77" @default.
• W3121991679 abstract "(1) Background: Enterococcus faecium DO is an environmental microbe, which is a mesophilic, facultative, Gram-positive, and multiple habitat microorganism. Enterococcus faecium DO is responsible for many diseases in human. The fight against infectious diseases is confronted by the development of multiple drug resistance in E. faecium. The focus of this research work is to identify a novel compound against this pathogen by using bioinformatics tools and technology. (2) Methods: We screened the proteome (accession No. PRJNA55353) information from the genome database of the National Centre for Biotechnology Information (NCBI) and suggested a potential drug target. I-TASSER was used to predict the three-dimensional structure of the protein, and the structure was optimized and minimized by different tools. PubChem and ChEBI were used to retrieve the inhibitors. Pharmacophore modeling and virtual screening were performed to identify novel compounds. Binding interactions of compounds with target protein were checked using LigPlot. pkCSM, SwissADME, and ProTox-II were used for adsorption, distribution, metabolism, excretion, and toxicity (ADMET) properties. (3) Results: Novel selected compounds have improved absorption and have better ADMET properties. Based on our results, the chemically identified inhibitor ZINC48942 targeted the receptor that can inhibit the activity of infection in E. faecium. This research work will be beneficial for the scientific community and could aid in the design of a new drug against E. faecium infections. (4) Conclusions: It was observed that novel compounds are potential inhibitors with more efficacy and fewer side effects. This research work will help researchers in testing and identification of these chemicals useful against E. faecium." @default.
• W3121991679 created "2021-02-01" @default.
• W3121991679 creator A5004973674 @default.
• W3121991679 creator A5006659275 @default.
• W3121991679 creator A5025269893 @default.
• W3121991679 creator A5030011967 @default.
• W3121991679 creator A5041672539 @default.
• W3121991679 creator A5044606252 @default.
• W3121991679 creator A5045696916 @default.
• W3121991679 creator A5066028225 @default.
• W3121991679 creator A5074022954 @default.
• W3121991679 creator A5083963903 @default.
• W3121991679 date "2021-01-21" @default.
• W3121991679 modified "2023-10-05" @default.
• W3121991679 title "Identification of Lead Compounds against Scm (fms10) in Enterococcus faecium Using Computer Aided Drug Designing" @default.
• W3121991679 cites W1533371356 @default.
• W3121991679 cites W1603231983 @default.
• W3121991679 cites W2006201402 @default.
• W3121991679 cites W2009867031 @default.
• W3121991679 cites W2021386749 @default.
• W3121991679 cites W2021832765 @default.
• W3121991679 cites W2037312364 @default.
• W3121991679 cites W2071486470 @default.
• W3121991679 cites W2080876451 @default.
• W3121991679 cites W2103599303 @default.
• W3121991679 cites W2105902442 @default.
• W3121991679 cites W2113623846 @default.
• W3121991679 cites W2137450588 @default.
• W3121991679 cites W2139164462 @default.
• W3121991679 cites W2140886260 @default.
• W3121991679 cites W2148615734 @default.
• W3121991679 cites W2152770371 @default.
• W3121991679 cites W2159614853 @default.
• W3121991679 cites W2162792752 @default.
• W3121991679 cites W2173732482 @default.
• W3121991679 cites W2176516200 @default.
• W3121991679 cites W2197630904 @default.
• W3121991679 cites W2316777574 @default.
• W3121991679 cites W2344557669 @default.
• W3121991679 cites W2588112065 @default.
• W3121991679 cites W2593436234 @default.
• W3121991679 cites W2611792444 @default.
• W3121991679 cites W2767557381 @default.
• W3121991679 cites W2801088198 @default.
• W3121991679 cites W2900102202 @default.
• W3121991679 cites W2900359059 @default.
• W3121991679 cites W2924290921 @default.
• W3121991679 cites W3136918052 @default.
• W3121991679 doi "https://doi.org/10.3390/life11020077" @default.
• W3121991679 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7909823" @default.
• W3121991679 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33494233" @default.
• W3121991679 hasPublicationYear "2021" @default.
• W3121991679 type Work @default.
• W3121991679 sameAs 3121991679 @default.
• W3121991679 citedByCount "39" @default.
• W3121991679 countsByYear W31219916792021 @default.
• W3121991679 countsByYear W31219916792022 @default.
• W3121991679 countsByYear W31219916792023 @default.
• W3121991679 crossrefType "journal-article" @default.
• W3121991679 hasAuthorship W3121991679A5004973674 @default.
• W3121991679 hasAuthorship W3121991679A5006659275 @default.
• W3121991679 hasAuthorship W3121991679A5025269893 @default.
• W3121991679 hasAuthorship W3121991679A5030011967 @default.
• W3121991679 hasAuthorship W3121991679A5041672539 @default.
• W3121991679 hasAuthorship W3121991679A5044606252 @default.
• W3121991679 hasAuthorship W3121991679A5045696916 @default.
• W3121991679 hasAuthorship W3121991679A5066028225 @default.
• W3121991679 hasAuthorship W3121991679A5074022954 @default.
• W3121991679 hasAuthorship W3121991679A5083963903 @default.
• W3121991679 hasBestOaLocation W31219916791 @default.
• W3121991679 hasConcept C103697762 @default.
• W3121991679 hasConcept C104317684 @default.
• W3121991679 hasConcept C104397665 @default.
• W3121991679 hasConcept C10679952 @default.
• W3121991679 hasConcept C158180186 @default.
• W3121991679 hasConcept C2777677444 @default.
• W3121991679 hasConcept C501593827 @default.
• W3121991679 hasConcept C55493867 @default.
• W3121991679 hasConcept C56173144 @default.
• W3121991679 hasConcept C60644358 @default.
• W3121991679 hasConcept C70721500 @default.
• W3121991679 hasConcept C86803240 @default.
• W3121991679 hasConcept C89423630 @default.
• W3121991679 hasConceptScore W3121991679C103697762 @default.
• W3121991679 hasConceptScore W3121991679C104317684 @default.
• W3121991679 hasConceptScore W3121991679C104397665 @default.
• W3121991679 hasConceptScore W3121991679C10679952 @default.
• W3121991679 hasConceptScore W3121991679C158180186 @default.
• W3121991679 hasConceptScore W3121991679C2777677444 @default.
• W3121991679 hasConceptScore W3121991679C501593827 @default.
• W3121991679 hasConceptScore W3121991679C55493867 @default.
• W3121991679 hasConceptScore W3121991679C56173144 @default.
• W3121991679 hasConceptScore W3121991679C60644358 @default.
• W3121991679 hasConceptScore W3121991679C70721500 @default.
• W3121991679 hasConceptScore W3121991679C86803240 @default.
• W3121991679 hasConceptScore W3121991679C89423630 @default.
• W3121991679 hasIssue "2" @default.
• W3121991679 hasLocation W31219916791 @default.

• next