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• W3122016054 abstract "Molecular switches are essential modules in signaling networks and transcriptional reprogramming. Here, we describe a role for small ubiquitin-related modifier SUMO as a molecular switch in epidermal growth factor receptor (EGFR) signaling. Using quantitative mass spectrometry, we compare the endogenous SUMO proteomes of HeLa cells before and after EGF stimulation. Thereby, we identify a small group of transcriptional coregulators including IRF2BP1, IRF2BP2, and IRF2BPL as novel players in EGFR signaling. Comparison of cells expressing wild type or SUMOylation-deficient IRF2BP1 indicates that transient deSUMOylation of IRF2BP proteins is important for appropriate expression of immediate early genes including dual specificity phosphatase 1 (DUSP1, MKP-1) and the transcription factor ATF3. We find that IRF2BP1 is a repressor, whose transient deSUMOylation on the DUSP1 promoter allows-and whose timely reSUMOylation restricts-DUSP1 transcription. Our work thus provides a paradigm how comparative SUMO proteome analyses serve to reveal novel regulators in signal transduction and transcription." @default.
• W3122016054 created "2021-02-01" @default.
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• W3122016054 creator A5000601814 @default.
• W3122016054 date "2021-01-22" @default.
• W3122016054 modified "2023-10-12" @default.
• W3122016054 title "Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling" @default.
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• W3122016054 doi "https://doi.org/10.15252/embr.201949651" @default.
• W3122016054 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7926235" @default.
• W3122016054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33480129" @default.
• W3122016054 hasPublicationYear "2021" @default.
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