Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122070565> ?p ?o ?g. }
Showing items 1 to 81 of
81
with 100 items per page.
- W3122070565 abstract "Coronavirus disease 2019 (COVID-19) from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in tremendous morbidity and mortality worldwide. A major underlying cause of COVID-19 mortality is a hyperinflammatory cytokine storm in severe/critically ill patients. Although many clinical trials are testing the efficacy of targeting inflammatory cytokines/chemokines in COVID-19 patients, the critical inflammatory mediator initiating COVID-19 patient death is undefined. Here we suggest that the immunopathological pathway leading to COVID-19 mortality can be divided into three stages with distinct clinical features that can be used to guide therapeutic strategies. Our interpretation of the recently published clinical trials from COVID-19 patients suggests that the clinical efficacy in preventing COVID-19 mortality using IL-1 blockade is subjected to notable caveats, while that for IL-6 blockade is suboptimal. We discuss critical factors in determining appropriate inflammatory cytokine/chemokine targets, timing, and combination of treatments to prevent COVID-19 mortality." @default.
- W3122070565 created "2021-02-01" @default.
- W3122070565 creator A5003759585 @default.
- W3122070565 creator A5008132835 @default.
- W3122070565 creator A5009198510 @default.
- W3122070565 creator A5015436826 @default.
- W3122070565 creator A5023266686 @default.
- W3122070565 creator A5023746467 @default.
- W3122070565 creator A5039010144 @default.
- W3122070565 creator A5070288393 @default.
- W3122070565 creator A5086232250 @default.
- W3122070565 date "2020-06-14" @default.
- W3122070565 modified "2023-10-18" @default.
- W3122070565 title "Preventing Mortality in COVID-19 Patients: Which Cytokine to Target in a Raging Storm?" @default.
- W3122070565 doi "https://doi.org/10.20944/preprints202006.0183.v1" @default.
- W3122070565 hasPublicationYear "2020" @default.
- W3122070565 type Work @default.
- W3122070565 sameAs 3122070565 @default.
- W3122070565 citedByCount "1" @default.
- W3122070565 countsByYear W31220705652021 @default.
- W3122070565 crossrefType "posted-content" @default.
- W3122070565 hasAuthorship W3122070565A5003759585 @default.
- W3122070565 hasAuthorship W3122070565A5008132835 @default.
- W3122070565 hasAuthorship W3122070565A5009198510 @default.
- W3122070565 hasAuthorship W3122070565A5015436826 @default.
- W3122070565 hasAuthorship W3122070565A5023266686 @default.
- W3122070565 hasAuthorship W3122070565A5023746467 @default.
- W3122070565 hasAuthorship W3122070565A5039010144 @default.
- W3122070565 hasAuthorship W3122070565A5070288393 @default.
- W3122070565 hasAuthorship W3122070565A5086232250 @default.
- W3122070565 hasBestOaLocation W31220705651 @default.
- W3122070565 hasConcept C126322002 @default.
- W3122070565 hasConcept C13373296 @default.
- W3122070565 hasConcept C170493617 @default.
- W3122070565 hasConcept C177713679 @default.
- W3122070565 hasConcept C203014093 @default.
- W3122070565 hasConcept C2776914184 @default.
- W3122070565 hasConcept C2777648638 @default.
- W3122070565 hasConcept C2778468042 @default.
- W3122070565 hasConcept C2778690821 @default.
- W3122070565 hasConcept C2779134260 @default.
- W3122070565 hasConcept C2779559532 @default.
- W3122070565 hasConcept C2780850621 @default.
- W3122070565 hasConcept C3008058167 @default.
- W3122070565 hasConcept C524204448 @default.
- W3122070565 hasConcept C535046627 @default.
- W3122070565 hasConcept C71924100 @default.
- W3122070565 hasConceptScore W3122070565C126322002 @default.
- W3122070565 hasConceptScore W3122070565C13373296 @default.
- W3122070565 hasConceptScore W3122070565C170493617 @default.
- W3122070565 hasConceptScore W3122070565C177713679 @default.
- W3122070565 hasConceptScore W3122070565C203014093 @default.
- W3122070565 hasConceptScore W3122070565C2776914184 @default.
- W3122070565 hasConceptScore W3122070565C2777648638 @default.
- W3122070565 hasConceptScore W3122070565C2778468042 @default.
- W3122070565 hasConceptScore W3122070565C2778690821 @default.
- W3122070565 hasConceptScore W3122070565C2779134260 @default.
- W3122070565 hasConceptScore W3122070565C2779559532 @default.
- W3122070565 hasConceptScore W3122070565C2780850621 @default.
- W3122070565 hasConceptScore W3122070565C3008058167 @default.
- W3122070565 hasConceptScore W3122070565C524204448 @default.
- W3122070565 hasConceptScore W3122070565C535046627 @default.
- W3122070565 hasConceptScore W3122070565C71924100 @default.
- W3122070565 hasLocation W31220705651 @default.
- W3122070565 hasLocation W31220705652 @default.
- W3122070565 hasOpenAccess W3122070565 @default.
- W3122070565 hasPrimaryLocation W31220705651 @default.
- W3122070565 hasRelatedWork W2070463916 @default.
- W3122070565 hasRelatedWork W2126005292 @default.
- W3122070565 hasRelatedWork W2471732223 @default.
- W3122070565 hasRelatedWork W3026277345 @default.
- W3122070565 hasRelatedWork W3046049650 @default.
- W3122070565 hasRelatedWork W3092259479 @default.
- W3122070565 hasRelatedWork W3093022044 @default.
- W3122070565 hasRelatedWork W4205132829 @default.
- W3122070565 hasRelatedWork W4224839121 @default.
- W3122070565 hasRelatedWork W4286669452 @default.
- W3122070565 isParatext "false" @default.
- W3122070565 isRetracted "false" @default.
- W3122070565 magId "3122070565" @default.
- W3122070565 workType "article" @default.