Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122132617> ?p ?o ?g. }
- W3122132617 abstract "Abstract Cancer cachexia is one of the most common causes of death among cancer patients, no effective anti-cachectic treatment is currently available. In experimental cachectic models, aberrant activation of STAT3 in skeletal muscle has been found to contribute to muscle wasting. However, its clinical association, the factors regulating STAT3 activation, and the molecular mechanisms of STAT3-induced muscle atrophy in cancer cachexia remain incompletely understood. Here, we show that an enhanced interaction between STAT3 and HSP90, which causes the persistent STAT3 activation in the skeletal muscle of cancer cachexia patients, is the crucial event for the development of cachectic muscle wasting. Administration of HSP90 inhibitors alleviated the muscle wasting in C26 tumor-bearing cachetic mice model or C26 conditional medium induced C2C12 myotube atrophy. A mechanistic study indicated that in cachectic skeletal muscle, prolonged STAT3 activation triggered muscle wasting in a FOXO1-dependent manner, STAT3 activated FOXO1 by binding directly to its promoter. Our results provide key insights into the role of the HSP90/STAT3/FOXO1 axis in cachectic muscle wasting, which shows promising therapeutic potential as a target for the treatment of cancer cachexia." @default.
- W3122132617 created "2021-02-01" @default.
- W3122132617 creator A5004945001 @default.
- W3122132617 creator A5006290340 @default.
- W3122132617 creator A5024200175 @default.
- W3122132617 creator A5026781859 @default.
- W3122132617 creator A5027475930 @default.
- W3122132617 creator A5041801320 @default.
- W3122132617 creator A5061005356 @default.
- W3122132617 creator A5073963878 @default.
- W3122132617 creator A5074877234 @default.
- W3122132617 creator A5079543105 @default.
- W3122132617 creator A5091817176 @default.
- W3122132617 date "2021-01-27" @default.
- W3122132617 modified "2023-10-18" @default.
- W3122132617 title "Inhibition of HSP90 reversed STAT3 mediated muscle wasting induced by cancer cachexia" @default.
- W3122132617 cites W1534582737 @default.
- W3122132617 cites W1964361372 @default.
- W3122132617 cites W1975484594 @default.
- W3122132617 cites W1981799488 @default.
- W3122132617 cites W1983411014 @default.
- W3122132617 cites W1983453744 @default.
- W3122132617 cites W1983660080 @default.
- W3122132617 cites W2002375890 @default.
- W3122132617 cites W2011567765 @default.
- W3122132617 cites W2017969831 @default.
- W3122132617 cites W2022531767 @default.
- W3122132617 cites W2027345997 @default.
- W3122132617 cites W2032674547 @default.
- W3122132617 cites W2037370931 @default.
- W3122132617 cites W2060902443 @default.
- W3122132617 cites W2074356752 @default.
- W3122132617 cites W2095801529 @default.
- W3122132617 cites W2113103362 @default.
- W3122132617 cites W2116618309 @default.
- W3122132617 cites W2126393987 @default.
- W3122132617 cites W2129034320 @default.
- W3122132617 cites W2141543467 @default.
- W3122132617 cites W2149423081 @default.
- W3122132617 cites W2149953626 @default.
- W3122132617 cites W2167033587 @default.
- W3122132617 cites W2170356930 @default.
- W3122132617 cites W2268856907 @default.
- W3122132617 cites W2490801415 @default.
- W3122132617 cites W2579783581 @default.
- W3122132617 cites W2587331503 @default.
- W3122132617 cites W2594758945 @default.
- W3122132617 cites W2606824156 @default.
- W3122132617 cites W2608317789 @default.
- W3122132617 cites W2739275966 @default.
- W3122132617 cites W2786987313 @default.
- W3122132617 cites W2789950188 @default.
- W3122132617 cites W2803261160 @default.
- W3122132617 cites W2804173788 @default.
- W3122132617 cites W2807617425 @default.
- W3122132617 cites W2886047510 @default.
- W3122132617 cites W2967561146 @default.
- W3122132617 cites W2997805606 @default.
- W3122132617 doi "https://doi.org/10.1101/2021.01.27.428420" @default.
- W3122132617 hasPublicationYear "2021" @default.
- W3122132617 type Work @default.
- W3122132617 sameAs 3122132617 @default.
- W3122132617 citedByCount "2" @default.
- W3122132617 countsByYear W31221326172021 @default.
- W3122132617 crossrefType "posted-content" @default.
- W3122132617 hasAuthorship W3122132617A5004945001 @default.
- W3122132617 hasAuthorship W3122132617A5006290340 @default.
- W3122132617 hasAuthorship W3122132617A5024200175 @default.
- W3122132617 hasAuthorship W3122132617A5026781859 @default.
- W3122132617 hasAuthorship W3122132617A5027475930 @default.
- W3122132617 hasAuthorship W3122132617A5041801320 @default.
- W3122132617 hasAuthorship W3122132617A5061005356 @default.
- W3122132617 hasAuthorship W3122132617A5073963878 @default.
- W3122132617 hasAuthorship W3122132617A5074877234 @default.
- W3122132617 hasAuthorship W3122132617A5079543105 @default.
- W3122132617 hasAuthorship W3122132617A5091817176 @default.
- W3122132617 hasBestOaLocation W31221326171 @default.
- W3122132617 hasConcept C121608353 @default.
- W3122132617 hasConcept C126322002 @default.
- W3122132617 hasConcept C134018914 @default.
- W3122132617 hasConcept C140149449 @default.
- W3122132617 hasConcept C207200792 @default.
- W3122132617 hasConcept C2776263037 @default.
- W3122132617 hasConcept C2777704314 @default.
- W3122132617 hasConcept C2778923194 @default.
- W3122132617 hasConcept C2779764123 @default.
- W3122132617 hasConcept C2779959927 @default.
- W3122132617 hasConcept C2781172350 @default.
- W3122132617 hasConcept C3763915 @default.
- W3122132617 hasConcept C502942594 @default.
- W3122132617 hasConcept C60278653 @default.
- W3122132617 hasConcept C62478195 @default.
- W3122132617 hasConcept C71924100 @default.
- W3122132617 hasConcept C75217442 @default.
- W3122132617 hasConcept C86803240 @default.
- W3122132617 hasConcept C95444343 @default.
- W3122132617 hasConceptScore W3122132617C121608353 @default.
- W3122132617 hasConceptScore W3122132617C126322002 @default.
- W3122132617 hasConceptScore W3122132617C134018914 @default.
- W3122132617 hasConceptScore W3122132617C140149449 @default.