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- W3122134310 abstract "Antiviral effectors such as natural killer (NK) cells have impaired functions in chronic hepatitis B (CHB) patients. The molecular mechanism responsible for this dysfunction remains poorly characterised. We show that decreased cytokine production capacity of peripheral NK cells from CHB patients was associated with reduced expression of NKp30 and CD16, and defective mTOR pathway activity. Transcriptome analysis of patients NK cells revealed an enrichment for transcripts expressed in exhausted T cells suggesting that NK cell dysfunction and T cell exhaustion employ common mechanisms. In particular, the transcription factor TOX and several of its targets were over-expressed in NK cells of CHB patients. This signature was predicted to be dependent on the calcium-associated transcription factor NFAT. Stimulation of the calcium-dependent pathway recapitulated features of NK cells from CHB patients. Thus, deregulated calcium signalling could be a central event in both T cell exhaustion and NK cell dysfunction occurring during chronic infections." @default.
- W3122134310 created "2021-02-01" @default.
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- W3122134310 date "2021-01-28" @default.
- W3122134310 modified "2023-10-14" @default.
- W3122134310 title "Peripheral natural killer cells in chronic hepatitis B patients display multiple molecular features of T cell exhaustion" @default.
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- W3122134310 cites W1970591872 @default.
- W3122134310 cites W1982123593 @default.
- W3122134310 cites W1986269759 @default.
- W3122134310 cites W1998407465 @default.
- W3122134310 cites W2006120252 @default.
- W3122134310 cites W2018775174 @default.
- W3122134310 cites W2035499322 @default.
- W3122134310 cites W2038600671 @default.
- W3122134310 cites W2045598455 @default.
- W3122134310 cites W2054119257 @default.
- W3122134310 cites W2054390178 @default.
- W3122134310 cites W2068767807 @default.
- W3122134310 cites W2077116159 @default.
- W3122134310 cites W2089247679 @default.
- W3122134310 cites W2089345792 @default.
- W3122134310 cites W2093189109 @default.
- W3122134310 cites W2094608386 @default.
- W3122134310 cites W2097855813 @default.
- W3122134310 cites W2099219082 @default.
- W3122134310 cites W2103972237 @default.
- W3122134310 cites W2104825199 @default.
- W3122134310 cites W2127334297 @default.
- W3122134310 cites W2127576269 @default.
- W3122134310 cites W2130854591 @default.
- W3122134310 cites W2134916334 @default.
- W3122134310 cites W2141248446 @default.
- W3122134310 cites W2157098396 @default.
- W3122134310 cites W2161589393 @default.
- W3122134310 cites W2170871835 @default.
- W3122134310 cites W2171709048 @default.
- W3122134310 cites W2287383446 @default.
- W3122134310 cites W2304688609 @default.
- W3122134310 cites W2407434056 @default.
- W3122134310 cites W2480418585 @default.
- W3122134310 cites W2507301821 @default.
- W3122134310 cites W2525998575 @default.
- W3122134310 cites W2580464105 @default.
- W3122134310 cites W2587331123 @default.
- W3122134310 cites W2592935721 @default.
- W3122134310 cites W2605785536 @default.
- W3122134310 cites W2750837483 @default.
- W3122134310 cites W2755711848 @default.
- W3122134310 cites W2763346562 @default.
- W3122134310 cites W2788660855 @default.
- W3122134310 cites W2792405992 @default.
- W3122134310 cites W2804786344 @default.
- W3122134310 cites W2805022017 @default.
- W3122134310 cites W2889656399 @default.
- W3122134310 cites W2890569696 @default.
- W3122134310 cites W2896939093 @default.
- W3122134310 cites W2912648593 @default.
- W3122134310 cites W2913423323 @default.
- W3122134310 cites W2916738215 @default.
- W3122134310 cites W2917547201 @default.
- W3122134310 cites W2918382496 @default.
- W3122134310 cites W2928665623 @default.
- W3122134310 cites W2947617159 @default.
- W3122134310 cites W2950413690 @default.
- W3122134310 cites W2951520325 @default.
- W3122134310 cites W2951598503 @default.
- W3122134310 cites W2952815301 @default.
- W3122134310 cites W2978325001 @default.
- W3122134310 cites W2979473668 @default.
- W3122134310 cites W2981274839 @default.
- W3122134310 cites W2990625270 @default.
- W3122134310 cites W2993746034 @default.
- W3122134310 cites W3038223554 @default.
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- W3122134310 doi "https://doi.org/10.7554/elife.60095" @default.
- W3122134310 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7870135" @default.
- W3122134310 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33507150" @default.
- W3122134310 hasPublicationYear "2021" @default.