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• W3122135514 abstract "Glucocorticoid‑induced osteoporosis is characterized by osteoblastic cell and microarchitecture dysfunction, as well as a loss of bone mass. Cell senescence contributes to the pathological process of osteoporosis and sodium hydrosulfide (NaHS) regulates the potent protective effects through delaying cell senescence. The aim of the present study was to investigate whether senescence could contribute to dexamethasone (Dex)‑induced osteoblast impairment and to examine the effect of NaHS on Dex‑induced cell senescence and damage. It was found that the levels of the senescence‑associated markers, p53 and p21, were markedly increased in osteoblasts exposed to Dex. A p53 inhibitor reversed Dex‑induced osteoblast injury, a process that was mitigated by NaHS administration through alleviating osteoblastic cell senescence. MicroRNA (miR)‑22 blocked the impact of NaHS on Dex‑induced osteoblast damage and senescence through targeting the regulation of Sirtuin 1 (sirt1) expression, as shown by the decreased cell viability and alkaline phosphatase activity, as well as an increased expression of p53 and p21. It was revealed that the sirt1 gene was the target of miR‑22 in osteoblastic MC3T3‑E1 cells through combining the results of dual luciferase reporter assays and reverse transcription‑quantitative PCR, as well as western blot analyses. Silencing of sirt1 abolished the protective effect of NaHS against Dex‑associated osteoblast senescence and injury. Taken together, the present study showed that NaHS prevents Dex‑induced cell senescence and damage through targeting the miR‑22/sirt1 pathway in osteoblastic MC3T3‑E1 cells." @default.
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• W3122135514 date "2021-01-21" @default.
• W3122135514 modified "2023-10-16" @default.
• W3122135514 title "Sodium hydrosulfide alleviates dexamethasone‑induced cell senescence and dysfunction through targeting the miR‑22/sirt1 pathway in osteoblastic MC3T3‑E1 cells" @default.
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• W3122135514 doi "https://doi.org/10.3892/etm.2021.9669" @default.
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