Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122144741> ?p ?o ?g. }
- W3122144741 endingPage "10" @default.
- W3122144741 startingPage "1" @default.
- W3122144741 abstract "Spina bifida (SB) is a neurogenetic disorder with a complex etiology that involves genetic and environmental factors. SB can occur in two major forms of open SB or SB aperta and closed SB or SB occulta. Myelomeningocele (MMC), the most common neural tube defects (NTDs), occurs in approximately 1 in 1,000 births. Considering non-genetic factors, diminished folate status is the best-known factor influencing NTD risk. The methylenetetrahydrofolate reductase (MTHFR) gene has been implicated as a risk factor for NTDs. The primary disorder in the pathogenesis of MMC is failed neural tube closure in the embryonic spinal region. The clinical manifestation of SB depends on clinical type and severity. SB can be detected in the second trimester using ultrasound which will reveal specific cranial signs. The management of MMC traditionally involves surgery within 48 h of birth. Prenatal repair of MMC is recommended for fetuses who meet maternal and fetal Management of Myelomeningocele Study (MOMS) specified criteria. Urological manifestations of SB include urinary incontinence, urolithiasis, sexual dysfunction, renal dysfunction, and urinary tract infection. Renal failure is among the most severe complications of SB. The most important role of the urologist is the management of neurogenic bladder. Medical management with clean intermittent catheterization and anticholinergic treatment is generally considered the gold standard of therapy. However, when this therapy fails surgical reconstruction become the only remaining option. This review will summarize the pathogenesis, risk factors, genetic contribution, diagnostic test, and management of SB. Lastly, the urologic outcomes and therapies are reviewed." @default.
- W3122144741 created "2021-02-01" @default.
- W3122144741 creator A5008543365 @default.
- W3122144741 creator A5013489107 @default.
- W3122144741 creator A5031070756 @default.
- W3122144741 creator A5048152483 @default.
- W3122144741 creator A5052817128 @default.
- W3122144741 creator A5053168470 @default.
- W3122144741 date "2021-02-28" @default.
- W3122144741 modified "2023-09-23" @default.
- W3122144741 title "Perspectives on urological care in spina bifida patients" @default.
- W3122144741 cites W144457721 @default.
- W3122144741 cites W1503297159 @default.
- W3122144741 cites W1538265666 @default.
- W3122144741 cites W1583086418 @default.
- W3122144741 cites W1851815938 @default.
- W3122144741 cites W1982189128 @default.
- W3122144741 cites W1991932966 @default.
- W3122144741 cites W1994427758 @default.
- W3122144741 cites W2004224047 @default.
- W3122144741 cites W2007934270 @default.
- W3122144741 cites W2008108249 @default.
- W3122144741 cites W2026996919 @default.
- W3122144741 cites W2030153957 @default.
- W3122144741 cites W2033546595 @default.
- W3122144741 cites W2035028103 @default.
- W3122144741 cites W2036923752 @default.
- W3122144741 cites W2057271667 @default.
- W3122144741 cites W2058478925 @default.
- W3122144741 cites W2060519152 @default.
- W3122144741 cites W2063852054 @default.
- W3122144741 cites W2067548558 @default.
- W3122144741 cites W2072431821 @default.
- W3122144741 cites W2075205721 @default.
- W3122144741 cites W2079486061 @default.
- W3122144741 cites W2084520793 @default.
- W3122144741 cites W2084697106 @default.
- W3122144741 cites W2091084439 @default.
- W3122144741 cites W2101359291 @default.
- W3122144741 cites W2103953947 @default.
- W3122144741 cites W2106579854 @default.
- W3122144741 cites W2107912295 @default.
- W3122144741 cites W2113309621 @default.
- W3122144741 cites W2124896347 @default.
- W3122144741 cites W2126037912 @default.
- W3122144741 cites W2129708751 @default.
- W3122144741 cites W2132760127 @default.
- W3122144741 cites W2149980112 @default.
- W3122144741 cites W2153818122 @default.
- W3122144741 cites W2157871694 @default.
- W3122144741 cites W2160459815 @default.
- W3122144741 cites W2162885870 @default.
- W3122144741 cites W2168747565 @default.
- W3122144741 cites W2175064395 @default.
- W3122144741 cites W2280913081 @default.
- W3122144741 cites W2292169465 @default.
- W3122144741 cites W2303890908 @default.
- W3122144741 cites W2328981861 @default.
- W3122144741 cites W2356860340 @default.
- W3122144741 cites W2465275747 @default.
- W3122144741 cites W2471001268 @default.
- W3122144741 cites W2499835487 @default.
- W3122144741 cites W2555855243 @default.
- W3122144741 cites W2587985956 @default.
- W3122144741 cites W2588942424 @default.
- W3122144741 cites W2611521644 @default.
- W3122144741 cites W2616628262 @default.
- W3122144741 cites W2621547859 @default.
- W3122144741 cites W2735028158 @default.
- W3122144741 cites W2742729241 @default.
- W3122144741 cites W2747753631 @default.
- W3122144741 cites W2751194890 @default.
- W3122144741 cites W2761589935 @default.
- W3122144741 cites W2765787579 @default.
- W3122144741 cites W2780872925 @default.
- W3122144741 cites W2786335802 @default.
- W3122144741 cites W2791320679 @default.
- W3122144741 cites W2793453773 @default.
- W3122144741 cites W2794325151 @default.
- W3122144741 cites W2803116439 @default.
- W3122144741 cites W2884728459 @default.
- W3122144741 cites W2898604263 @default.
- W3122144741 cites W2901048811 @default.
- W3122144741 cites W2911104740 @default.
- W3122144741 cites W2923453665 @default.
- W3122144741 cites W2934425633 @default.
- W3122144741 cites W2966060723 @default.
- W3122144741 cites W2967766231 @default.
- W3122144741 cites W2977989659 @default.
- W3122144741 cites W3023913436 @default.
- W3122144741 cites W4210319618 @default.
- W3122144741 cites W4210991235 @default.
- W3122144741 cites W4235471822 @default.
- W3122144741 doi "https://doi.org/10.5582/irdr.2020.03077" @default.
- W3122144741 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7882087" @default.
- W3122144741 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33614369" @default.
- W3122144741 hasPublicationYear "2021" @default.
- W3122144741 type Work @default.