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- W3122155574 abstract "Significance Neuroblastoma is a childhood malignancy that originates from neural crest cells. We present a single-cell transcriptome and localization atlas of the developing adrenal gland and identify seven different cell clusters that make up the adrenal medulla. Their transcriptomic profiles were used to generate gene signatures that were compared to neuroblastoma samples. The neural crest-derived “SCP” gene signature score anticorrelates with disease severity based on staging and poor prognosis (molecular) markers, while a high score was associated with higher overall survival rates." @default.
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- W3122155574 date "2021-01-26" @default.
- W3122155574 modified "2023-10-13" @default.
- W3122155574 title "Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype" @default.
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- W3122155574 doi "https://doi.org/10.1073/pnas.2022350118" @default.
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