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- W3122244534 endingPage "041" @default.
- W3122244534 startingPage "028" @default.
- W3122244534 abstract "Hepatoblastoma (HB) is the predominant primary liver tumor in children. While the prognosis is favorable when the tumor can be resected, the outcome is dismal for patients with progressed HB. Therefore, a better understanding of the molecular mechanisms responsible for HB is imperative for early detection and effective treatment. Sequencing analysis of human HB specimens unraveled the pivotal role of Wnt/β-catenin pathway activation in this disease. Nonetheless, β-catenin activation alone does not suffice to induce HB, implying the need for additional alterations. Perturbations of several pathways, including Hippo, Hedgehog, NRF2/KEAP1, HGF/c-Met, NK-1R/SP, and PI3K/AKT/mTOR cascades and aberrant activation of c-MYC, n-MYC, and EZH2 proto-oncogenes, have been identified in HB, although their role requires additional investigation. Here, we summarize the current knowledge on HB molecular pathogenesis, the relevance of the preclinical findings for the human disease, and the innovative therapeutic strategies that could be beneficial for the treatment of HB patients." @default.
- W3122244534 created "2021-02-01" @default.
- W3122244534 creator A5022582588 @default.
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- W3122244534 creator A5064003777 @default.
- W3122244534 creator A5091038323 @default.
- W3122244534 date "2021-01-01" @default.
- W3122244534 modified "2023-10-02" @default.
- W3122244534 title "Molecular Mechanisms of Hepatoblastoma" @default.
- W3122244534 cites W1564820488 @default.
- W3122244534 cites W1566241906 @default.
- W3122244534 cites W1578810612 @default.
- W3122244534 cites W19457734 @default.
- W3122244534 cites W1967473522 @default.
- W3122244534 cites W1972584513 @default.
- W3122244534 cites W1974532695 @default.
- W3122244534 cites W1974937624 @default.
- W3122244534 cites W1976106807 @default.
- W3122244534 cites W1978930610 @default.
- W3122244534 cites W1979391302 @default.
- W3122244534 cites W1981515025 @default.
- W3122244534 cites W1983961063 @default.
- W3122244534 cites W1992214889 @default.
- W3122244534 cites W1998628636 @default.
- W3122244534 cites W1999150319 @default.
- W3122244534 cites W2001568293 @default.
- W3122244534 cites W2002828077 @default.
- W3122244534 cites W2004480757 @default.
- W3122244534 cites W2010838797 @default.
- W3122244534 cites W2011585726 @default.
- W3122244534 cites W2019800711 @default.
- W3122244534 cites W2021536610 @default.
- W3122244534 cites W2021999094 @default.
- W3122244534 cites W2024174401 @default.
- W3122244534 cites W2025351114 @default.
- W3122244534 cites W2025908319 @default.
- W3122244534 cites W2031671750 @default.
- W3122244534 cites W2033127461 @default.
- W3122244534 cites W2037436568 @default.
- W3122244534 cites W2039640335 @default.
- W3122244534 cites W2046427987 @default.
- W3122244534 cites W2050345955 @default.
- W3122244534 cites W2050754396 @default.
- W3122244534 cites W2053421436 @default.
- W3122244534 cites W2054368385 @default.
- W3122244534 cites W2055254495 @default.
- W3122244534 cites W2060661794 @default.
- W3122244534 cites W2060696771 @default.
- W3122244534 cites W2070016388 @default.
- W3122244534 cites W2080880470 @default.
- W3122244534 cites W2084001039 @default.
- W3122244534 cites W2085197940 @default.
- W3122244534 cites W2091734645 @default.
- W3122244534 cites W2097409998 @default.
- W3122244534 cites W2097774235 @default.
- W3122244534 cites W2099343472 @default.
- W3122244534 cites W2099735441 @default.
- W3122244534 cites W2100086304 @default.
- W3122244534 cites W2107457935 @default.
- W3122244534 cites W2108643617 @default.
- W3122244534 cites W2108707301 @default.
- W3122244534 cites W2115868832 @default.
- W3122244534 cites W2117750856 @default.
- W3122244534 cites W2118961722 @default.
- W3122244534 cites W2120572492 @default.
- W3122244534 cites W2121941459 @default.
- W3122244534 cites W2127105373 @default.
- W3122244534 cites W2127625111 @default.
- W3122244534 cites W2128085817 @default.
- W3122244534 cites W2131087768 @default.
- W3122244534 cites W2133069560 @default.
- W3122244534 cites W2134137083 @default.
- W3122244534 cites W2137740979 @default.
- W3122244534 cites W2144991849 @default.
- W3122244534 cites W2148294117 @default.
- W3122244534 cites W2156238103 @default.
- W3122244534 cites W2158021558 @default.
- W3122244534 cites W2162261339 @default.
- W3122244534 cites W2164511212 @default.
- W3122244534 cites W2166545908 @default.
- W3122244534 cites W2166965065 @default.
- W3122244534 cites W2168180694 @default.
- W3122244534 cites W2170664715 @default.
- W3122244534 cites W2172179525 @default.
- W3122244534 cites W2181996073 @default.
- W3122244534 cites W2196709022 @default.
- W3122244534 cites W2261299995 @default.
- W3122244534 cites W2264682687 @default.
- W3122244534 cites W2326335870 @default.
- W3122244534 cites W2333855854 @default.
- W3122244534 cites W2344739336 @default.
- W3122244534 cites W2395187393 @default.
- W3122244534 cites W2417535489 @default.
- W3122244534 cites W2504210139 @default.
- W3122244534 cites W2519909886 @default.
- W3122244534 cites W2529522407 @default.