Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122280560> ?p ?o ?g. }
- W3122280560 abstract "Abstract Hepatitis delta virus (HDV) is a satellite virus that requires hepadnavirus envelope proteins for its transmission. Although recent studies identified HDV-related deltaviruses in certain animals, the evolution of deltaviruses, such as the origin of HDV and the mechanism of its coevolution with its helper viruses, is unknown, mainly because of the phylogenetic gaps among deltaviruses. Here, we identified novel deltaviruses of passerine birds, woodchucks, and white-tailed deer by extensive database searches and molecular surveillance. Phylogenetic and molecular epidemiological analyses suggest that HDV originated from mammalian deltaviruses and the past interspecies transmission of mammalian and passerine deltaviruses. Further, metaviromic and experimental analyses suggest that the satellite–helper relationship between HDV and hepadnavirus was established after the divergence of the HDV lineage from non-HDV mammalian deltaviruses. Our findings enhance our understanding of deltavirus evolution, diversity, and transmission, indicating the importance of further surveillance for deltaviruses." @default.
- W3122280560 created "2021-02-01" @default.
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- W3122280560 date "2021-01-01" @default.
- W3122280560 modified "2023-10-16" @default.
- W3122280560 title "Identification of novel avian and mammalian deltaviruses provides new insights into deltavirus evolution" @default.
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- W3122280560 doi "https://doi.org/10.1093/ve/veab003" @default.
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