Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122322372> ?p ?o ?g. }
- W3122322372 abstract "Several cytoskeleton-associated proteins and signaling pathways work in concert to regulate actin cytoskeleton remodeling, cell adhesion, and migration. Although the leukocyte-specific protein 1 (LSP1) has been shown to interact with the actin cytoskeleton, its function in the regulation of actin cytoskeleton dynamics is, as yet, not fully understood. We have recently demonstrated that the bimolecular complex between LSP1 and myosin1e controls actin cytoskeleton remodeling during phagocytosis. In this study, we show that LSP1 downregulation severely impairs cell migration, lamellipodia formation, and focal adhesion dynamics in macrophages. Inhibition of the interaction between LSP1 and myosin1e also impairs these processes resulting in poorly motile cells, which are characterized by few and small lamellipodia. Furthermore, cells in which LSP1-myosin1e interaction is inhibited are typically associated with inefficient focal adhesion turnover. Collectively, our findings show that the LSP1-myosin1e bimolecular complex plays a pivotal role in the regulation of actin cytoskeleton remodeling and focal adhesion dynamics required for cell migration." @default.
- W3122322372 created "2021-02-01" @default.
- W3122322372 creator A5000449396 @default.
- W3122322372 creator A5004290451 @default.
- W3122322372 creator A5050844454 @default.
- W3122322372 creator A5068810578 @default.
- W3122322372 creator A5077350273 @default.
- W3122322372 creator A5077770770 @default.
- W3122322372 date "2021-01-20" @default.
- W3122322372 modified "2023-10-18" @default.
- W3122322372 title "LSP1‐myosin1e bimolecular complex regulates focal adhesion dynamics and cell migration" @default.
- W3122322372 cites W1479918734 @default.
- W3122322372 cites W149540474 @default.
- W3122322372 cites W1548125733 @default.
- W3122322372 cites W1554194168 @default.
- W3122322372 cites W1583390737 @default.
- W3122322372 cites W1692680392 @default.
- W3122322372 cites W1824394307 @default.
- W3122322372 cites W1909452053 @default.
- W3122322372 cites W1966124746 @default.
- W3122322372 cites W1976759961 @default.
- W3122322372 cites W1986039994 @default.
- W3122322372 cites W1986717719 @default.
- W3122322372 cites W1987100029 @default.
- W3122322372 cites W1996863275 @default.
- W3122322372 cites W2009482382 @default.
- W3122322372 cites W2033669048 @default.
- W3122322372 cites W2041098549 @default.
- W3122322372 cites W2050031945 @default.
- W3122322372 cites W2051805967 @default.
- W3122322372 cites W2055467083 @default.
- W3122322372 cites W2062896090 @default.
- W3122322372 cites W2070392595 @default.
- W3122322372 cites W2072849030 @default.
- W3122322372 cites W2073238252 @default.
- W3122322372 cites W2076246581 @default.
- W3122322372 cites W2082361269 @default.
- W3122322372 cites W2093881419 @default.
- W3122322372 cites W2095866816 @default.
- W3122322372 cites W2097461815 @default.
- W3122322372 cites W2100896736 @default.
- W3122322372 cites W2103773342 @default.
- W3122322372 cites W2104055042 @default.
- W3122322372 cites W2107982044 @default.
- W3122322372 cites W2108848762 @default.
- W3122322372 cites W2111750583 @default.
- W3122322372 cites W2119563328 @default.
- W3122322372 cites W2121302773 @default.
- W3122322372 cites W2127096584 @default.
- W3122322372 cites W2137284738 @default.
- W3122322372 cites W2141292418 @default.
- W3122322372 cites W2141664507 @default.
- W3122322372 cites W2145123926 @default.
- W3122322372 cites W2148153432 @default.
- W3122322372 cites W2149933072 @default.
- W3122322372 cites W2152002380 @default.
- W3122322372 cites W2161237382 @default.
- W3122322372 cites W2166545694 @default.
- W3122322372 cites W2168957799 @default.
- W3122322372 cites W2169398513 @default.
- W3122322372 cites W2271859828 @default.
- W3122322372 cites W2272602445 @default.
- W3122322372 cites W2278700699 @default.
- W3122322372 cites W2280143417 @default.
- W3122322372 cites W234649 @default.
- W3122322372 cites W2479694076 @default.
- W3122322372 cites W2495580168 @default.
- W3122322372 cites W2571734993 @default.
- W3122322372 cites W2788577149 @default.
- W3122322372 cites W336058209 @default.
- W3122322372 cites W4245729482 @default.
- W3122322372 cites W7000534 @default.
- W3122322372 doi "https://doi.org/10.1096/fj.202000740rr" @default.
- W3122322372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33470457" @default.
- W3122322372 hasPublicationYear "2021" @default.
- W3122322372 type Work @default.
- W3122322372 sameAs 3122322372 @default.
- W3122322372 citedByCount "9" @default.
- W3122322372 countsByYear W31223223722021 @default.
- W3122322372 countsByYear W31223223722022 @default.
- W3122322372 countsByYear W31223223722023 @default.
- W3122322372 crossrefType "journal-article" @default.
- W3122322372 hasAuthorship W3122322372A5000449396 @default.
- W3122322372 hasAuthorship W3122322372A5004290451 @default.
- W3122322372 hasAuthorship W3122322372A5050844454 @default.
- W3122322372 hasAuthorship W3122322372A5068810578 @default.
- W3122322372 hasAuthorship W3122322372A5077350273 @default.
- W3122322372 hasAuthorship W3122322372A5077770770 @default.
- W3122322372 hasBestOaLocation W31223223722 @default.
- W3122322372 hasConcept C109185818 @default.
- W3122322372 hasConcept C125705527 @default.
- W3122322372 hasConcept C137738243 @default.
- W3122322372 hasConcept C142669718 @default.
- W3122322372 hasConcept C1491633281 @default.
- W3122322372 hasConcept C151166631 @default.
- W3122322372 hasConcept C178790620 @default.
- W3122322372 hasConcept C185592680 @default.
- W3122322372 hasConcept C2993400109 @default.
- W3122322372 hasConcept C3620293 @default.
- W3122322372 hasConcept C55493867 @default.