Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122328148> ?p ?o ?g. }
- W3122328148 endingPage "846" @default.
- W3122328148 startingPage "831" @default.
- W3122328148 abstract "The current in-vivo study was premeditated to uncover the protective role of ezetimibe (EZ) against advanced glycation endproducts (AGEs)-related pathologies in experimental diabetes. Our results showed that EZ markedly improved the altered biochemical markers of diabetes mellitus (DM) (FBG, HbA1c, insulin, microalbumin, and creatinine) and cardiovascular disease (in-vivo lipid/lipoprotein level and hepatic HMG-CoA reductase activity) along with diminished plasma carboxymethyl-lysine (CML) and renal fluorescent AGEs level. Gene expression study revealed that EZ significantly down-regulated the renal AGEs-receptor (RAGE), nuclear factor-κB (NFκB-2), transforming growth factor-β (TGF-β1), and matrix metalloproteinase-2 (MMP-2) mRNA expression, however, the neuropilin-1 (NRP-1) mRNA expression was up-regulated. In addition, EZ also maintained the redox status via decreasing the lipid peroxidation and protein-bound carbonyl content (CC) and increasing the activity of high-density lipoprotein (HDL)-associated-paraoxonase-1 (PON-1) and renal antioxidant enzymes as well as also protected renal histopathological features. We conclude that EZ exhibits antidiabetic and reno-protective properties in diabetic rats." @default.
- W3122328148 created "2021-02-01" @default.
- W3122328148 creator A5006558608 @default.
- W3122328148 creator A5006940868 @default.
- W3122328148 creator A5027051626 @default.
- W3122328148 creator A5040793676 @default.
- W3122328148 creator A5042185432 @default.
- W3122328148 creator A5058401229 @default.
- W3122328148 creator A5059161145 @default.
- W3122328148 creator A5073522682 @default.
- W3122328148 date "2021-01-29" @default.
- W3122328148 modified "2023-09-25" @default.
- W3122328148 title "Ezetimibe attenuates experimental diabetes and renal pathologies via targeting the advanced glycation, oxidative stress and AGE-RAGE signalling in rats" @default.
- W3122328148 cites W1508167383 @default.
- W3122328148 cites W1511701404 @default.
- W3122328148 cites W1530574859 @default.
- W3122328148 cites W1545899030 @default.
- W3122328148 cites W1581414347 @default.
- W3122328148 cites W1885679900 @default.
- W3122328148 cites W1942583428 @default.
- W3122328148 cites W1963561631 @default.
- W3122328148 cites W1979541659 @default.
- W3122328148 cites W1983310681 @default.
- W3122328148 cites W1986025060 @default.
- W3122328148 cites W1993652095 @default.
- W3122328148 cites W1997314757 @default.
- W3122328148 cites W2019226618 @default.
- W3122328148 cites W2029385729 @default.
- W3122328148 cites W2042130085 @default.
- W3122328148 cites W2076914555 @default.
- W3122328148 cites W2086327676 @default.
- W3122328148 cites W2093022509 @default.
- W3122328148 cites W2093862029 @default.
- W3122328148 cites W2096795975 @default.
- W3122328148 cites W2097888088 @default.
- W3122328148 cites W2103190648 @default.
- W3122328148 cites W2104005551 @default.
- W3122328148 cites W2114751358 @default.
- W3122328148 cites W2116404316 @default.
- W3122328148 cites W2146979664 @default.
- W3122328148 cites W2156534751 @default.
- W3122328148 cites W2159272194 @default.
- W3122328148 cites W2159937805 @default.
- W3122328148 cites W2160664288 @default.
- W3122328148 cites W2165292984 @default.
- W3122328148 cites W2168526937 @default.
- W3122328148 cites W2509824523 @default.
- W3122328148 cites W2537388257 @default.
- W3122328148 cites W2565823552 @default.
- W3122328148 cites W2607363770 @default.
- W3122328148 cites W2615714795 @default.
- W3122328148 cites W2769052489 @default.
- W3122328148 cites W2772173038 @default.
- W3122328148 cites W2775762066 @default.
- W3122328148 cites W2780743843 @default.
- W3122328148 cites W2787269887 @default.
- W3122328148 cites W2804210244 @default.
- W3122328148 cites W2872350967 @default.
- W3122328148 cites W2886442927 @default.
- W3122328148 cites W2893354709 @default.
- W3122328148 cites W2903177493 @default.
- W3122328148 cites W2942473226 @default.
- W3122328148 cites W2949322970 @default.
- W3122328148 cites W2960158030 @default.
- W3122328148 cites W2962076438 @default.
- W3122328148 cites W2969936136 @default.
- W3122328148 cites W2970525791 @default.
- W3122328148 cites W2971873804 @default.
- W3122328148 cites W2973314788 @default.
- W3122328148 cites W2981709735 @default.
- W3122328148 cites W2995814691 @default.
- W3122328148 cites W3007498336 @default.
- W3122328148 cites W3012797582 @default.
- W3122328148 cites W3019432413 @default.
- W3122328148 cites W3023549981 @default.
- W3122328148 doi "https://doi.org/10.1080/13813455.2021.1874996" @default.
- W3122328148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33508970" @default.
- W3122328148 hasPublicationYear "2021" @default.
- W3122328148 type Work @default.
- W3122328148 sameAs 3122328148 @default.
- W3122328148 citedByCount "12" @default.
- W3122328148 countsByYear W31223281482021 @default.
- W3122328148 countsByYear W31223281482022 @default.
- W3122328148 countsByYear W31223281482023 @default.
- W3122328148 crossrefType "journal-article" @default.
- W3122328148 hasAuthorship W3122328148A5006558608 @default.
- W3122328148 hasAuthorship W3122328148A5006940868 @default.
- W3122328148 hasAuthorship W3122328148A5027051626 @default.
- W3122328148 hasAuthorship W3122328148A5040793676 @default.
- W3122328148 hasAuthorship W3122328148A5042185432 @default.
- W3122328148 hasAuthorship W3122328148A5058401229 @default.
- W3122328148 hasAuthorship W3122328148A5059161145 @default.
- W3122328148 hasAuthorship W3122328148A5073522682 @default.
- W3122328148 hasConcept C126322002 @default.
- W3122328148 hasConcept C134018914 @default.
- W3122328148 hasConcept C147990577 @default.
- W3122328148 hasConcept C169760540 @default.
- W3122328148 hasConcept C185592680 @default.