Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122336767> ?p ?o ?g. }
- W3122336767 endingPage "108982" @default.
- W3122336767 startingPage "108982" @default.
- W3122336767 abstract "The present study explored the possible mitigative effects of vitamin D3 (VD3) on lipopolysaccharide (LPS)-induced intestinal oxidative stress, inflammatory response and tight junction damage in yellow catfish, Pelteobagrus fulvidraco. Herein, four experimental groups were established by injecting yellow catfish with NaCl, LPS, VD3 or LPS plus VD3. The results showed that LPS induced oxidative stress and that exogenous VD3 mitigated the adverse effects of LPS. Additionally, LPS suppressed the activity of antioxidant enzymes (Cat, Sod and Gr) and upregulated the mRNA expression of proinflammatory cytokines (Tnf-α, Il-1β, Il-8). Furthermore, the mRNA expression of “fencing” tight junctions (Claudin-1, Claudin-5, Occludin, Zo-1) was downregulated, while that of “pore-forming” tight junctions (Claudin-2, Claudin-12) was upregulated, however no effect on apoptosis genes was observed (p53, Bax, Caspase-3 and Caspase-9). These LPS-induced effects were significantly reversed by pretreatment with VD3. Taken together, this study suggests that exogenous VD3 substantially alleviates LPS-induced intestinal inflammation by upregulating antioxidant activity, suppressing inflammation and promoting fencing tight junctions in the intestine." @default.
- W3122336767 created "2021-02-01" @default.
- W3122336767 creator A5019373327 @default.
- W3122336767 creator A5048999041 @default.
- W3122336767 creator A5051364084 @default.
- W3122336767 creator A5087791435 @default.
- W3122336767 creator A5088702316 @default.
- W3122336767 date "2021-05-01" @default.
- W3122336767 modified "2023-10-14" @default.
- W3122336767 title "Vitamin D3 mitigates lipopolysaccharide-induced oxidative stress, tight junction damage and intestinal inflammatory response in yellow catfish, Pelteobagrus fulvidraco" @default.
- W3122336767 cites W1458687811 @default.
- W3122336767 cites W1514116720 @default.
- W3122336767 cites W1590457525 @default.
- W3122336767 cites W1750397992 @default.
- W3122336767 cites W191793640 @default.
- W3122336767 cites W1975641381 @default.
- W3122336767 cites W1977368374 @default.
- W3122336767 cites W1979873115 @default.
- W3122336767 cites W1990995931 @default.
- W3122336767 cites W1999272644 @default.
- W3122336767 cites W2003303727 @default.
- W3122336767 cites W2004359355 @default.
- W3122336767 cites W2009144884 @default.
- W3122336767 cites W2027755570 @default.
- W3122336767 cites W2028789107 @default.
- W3122336767 cites W2042878075 @default.
- W3122336767 cites W2045084108 @default.
- W3122336767 cites W2052772855 @default.
- W3122336767 cites W2063474682 @default.
- W3122336767 cites W2073092594 @default.
- W3122336767 cites W2075109140 @default.
- W3122336767 cites W2077785032 @default.
- W3122336767 cites W2077816151 @default.
- W3122336767 cites W2085580868 @default.
- W3122336767 cites W2087543974 @default.
- W3122336767 cites W2089297960 @default.
- W3122336767 cites W2100093202 @default.
- W3122336767 cites W2101422765 @default.
- W3122336767 cites W2107277218 @default.
- W3122336767 cites W2111567870 @default.
- W3122336767 cites W2113999599 @default.
- W3122336767 cites W2126626992 @default.
- W3122336767 cites W2133538175 @default.
- W3122336767 cites W2144856600 @default.
- W3122336767 cites W2155144135 @default.
- W3122336767 cites W2165989629 @default.
- W3122336767 cites W2319718545 @default.
- W3122336767 cites W2330707041 @default.
- W3122336767 cites W2339470454 @default.
- W3122336767 cites W2397636493 @default.
- W3122336767 cites W2507260480 @default.
- W3122336767 cites W2736509374 @default.
- W3122336767 cites W2746976743 @default.
- W3122336767 cites W2752348434 @default.
- W3122336767 cites W2753956316 @default.
- W3122336767 cites W2781816595 @default.
- W3122336767 cites W2783895215 @default.
- W3122336767 cites W2799356795 @default.
- W3122336767 cites W2803191813 @default.
- W3122336767 cites W2809697521 @default.
- W3122336767 cites W2899783315 @default.
- W3122336767 cites W2900542959 @default.
- W3122336767 cites W2969537244 @default.
- W3122336767 cites W2981074146 @default.
- W3122336767 cites W2993445713 @default.
- W3122336767 cites W2996685238 @default.
- W3122336767 cites W2999358931 @default.
- W3122336767 cites W3005914569 @default.
- W3122336767 cites W3008577013 @default.
- W3122336767 cites W3017530784 @default.
- W3122336767 cites W3023347551 @default.
- W3122336767 cites W3026170167 @default.
- W3122336767 cites W3028020192 @default.
- W3122336767 cites W3028820974 @default.
- W3122336767 cites W3034449077 @default.
- W3122336767 cites W3035481337 @default.
- W3122336767 cites W3036600170 @default.
- W3122336767 cites W3042620746 @default.
- W3122336767 cites W4313377128 @default.
- W3122336767 doi "https://doi.org/10.1016/j.cbpc.2021.108982" @default.
- W3122336767 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33497802" @default.
- W3122336767 hasPublicationYear "2021" @default.
- W3122336767 type Work @default.
- W3122336767 sameAs 3122336767 @default.
- W3122336767 citedByCount "16" @default.
- W3122336767 countsByYear W31223367672021 @default.
- W3122336767 countsByYear W31223367672022 @default.
- W3122336767 countsByYear W31223367672023 @default.
- W3122336767 crossrefType "journal-article" @default.
- W3122336767 hasAuthorship W3122336767A5019373327 @default.
- W3122336767 hasAuthorship W3122336767A5048999041 @default.
- W3122336767 hasAuthorship W3122336767A5051364084 @default.
- W3122336767 hasAuthorship W3122336767A5087791435 @default.
- W3122336767 hasAuthorship W3122336767A5088702316 @default.
- W3122336767 hasConcept C104317684 @default.
- W3122336767 hasConcept C127561419 @default.
- W3122336767 hasConcept C134018914 @default.
- W3122336767 hasConcept C164027704 @default.