Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122337303> ?p ?o ?g. }
- W3122337303 endingPage "2174" @default.
- W3122337303 startingPage "2149" @default.
- W3122337303 abstract "Immunodeficiency and hyperinflammation are responsible for the most frequent and life-threatening forms of coronavirus disease 2019 (COVID-19). Therefore, cytokine-based treatments targeting immuno-inflammatory mechanisms are currently undergoing clinical scrutiny in COVID-19-affected patients. In addition, COVID-19 patients also exhibit a wide range of neurological manifestations (neuro-COVID), which may also benefit from cytokine-based treatments. In fact, such drugs have shown some clinical efficacy also in neuroinflammatory diseases. On the other hand, anti-cytokine drugs are endowed with significant neurological risks, mainly attributable to their immunodepressant effects. Therefore, the aim of the present manuscript is to briefly describe the role of specific cytokines in neuroinflammation, to summarize the efficacy in preclinical models of neuroinflammatory diseases of drugs targeting these cytokines and to review the clinical data regarding the neurological effects of these drugs currently being investigated against COVID-19, in order to raise awareness about their potentially beneficial and/or detrimental neurological consequences. LINKED ARTICLES: This article is part of a themed issue on The second wave: are we any closer to efficacious pharmacotherapy for COVID 19? (BJP 75th Anniversary). To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.10/issuetoc." @default.
- W3122337303 created "2021-02-01" @default.
- W3122337303 creator A5045997228 @default.
- W3122337303 creator A5057579624 @default.
- W3122337303 creator A5061843273 @default.
- W3122337303 date "2021-03-12" @default.
- W3122337303 modified "2023-09-27" @default.
- W3122337303 title "Neurological risks and benefits of cytokine‐based treatments in coronavirus disease 2019: from preclinical to clinical evidence" @default.
- W3122337303 cites W1511803494 @default.
- W3122337303 cites W1723158139 @default.
- W3122337303 cites W1753490518 @default.
- W3122337303 cites W1905630967 @default.
- W3122337303 cites W1916318763 @default.
- W3122337303 cites W1965481178 @default.
- W3122337303 cites W1976108601 @default.
- W3122337303 cites W1988487111 @default.
- W3122337303 cites W1988563263 @default.
- W3122337303 cites W1993738319 @default.
- W3122337303 cites W1994844769 @default.
- W3122337303 cites W1995146839 @default.
- W3122337303 cites W1999383442 @default.
- W3122337303 cites W2000614107 @default.
- W3122337303 cites W2002536602 @default.
- W3122337303 cites W2006470317 @default.
- W3122337303 cites W2007147688 @default.
- W3122337303 cites W2008437574 @default.
- W3122337303 cites W2012195969 @default.
- W3122337303 cites W2014424956 @default.
- W3122337303 cites W2020019417 @default.
- W3122337303 cites W2023071639 @default.
- W3122337303 cites W2028398681 @default.
- W3122337303 cites W2030117383 @default.
- W3122337303 cites W2030534917 @default.
- W3122337303 cites W2033550244 @default.
- W3122337303 cites W2035053927 @default.
- W3122337303 cites W2046684735 @default.
- W3122337303 cites W2047436972 @default.
- W3122337303 cites W2052593121 @default.
- W3122337303 cites W2062848241 @default.
- W3122337303 cites W2065429450 @default.
- W3122337303 cites W2070125035 @default.
- W3122337303 cites W2072096408 @default.
- W3122337303 cites W2087956057 @default.
- W3122337303 cites W2098522135 @default.
- W3122337303 cites W2099480987 @default.
- W3122337303 cites W2101172791 @default.
- W3122337303 cites W2102562492 @default.
- W3122337303 cites W2104575230 @default.
- W3122337303 cites W2119582157 @default.
- W3122337303 cites W2122562716 @default.
- W3122337303 cites W2124072861 @default.
- W3122337303 cites W2127758278 @default.
- W3122337303 cites W2128623935 @default.
- W3122337303 cites W2131789215 @default.
- W3122337303 cites W2133402546 @default.
- W3122337303 cites W2133830421 @default.
- W3122337303 cites W2139253645 @default.
- W3122337303 cites W2142039618 @default.
- W3122337303 cites W2145526657 @default.
- W3122337303 cites W2148235686 @default.
- W3122337303 cites W2148637723 @default.
- W3122337303 cites W2159235876 @default.
- W3122337303 cites W2162981836 @default.
- W3122337303 cites W2164179897 @default.
- W3122337303 cites W2166650533 @default.
- W3122337303 cites W2166787544 @default.
- W3122337303 cites W2169071602 @default.
- W3122337303 cites W2171556560 @default.
- W3122337303 cites W2178210969 @default.
- W3122337303 cites W2186608581 @default.
- W3122337303 cites W2190558971 @default.
- W3122337303 cites W2209331389 @default.
- W3122337303 cites W2228881750 @default.
- W3122337303 cites W2297732912 @default.
- W3122337303 cites W2326219627 @default.
- W3122337303 cites W2329190288 @default.
- W3122337303 cites W2338073571 @default.
- W3122337303 cites W2404054411 @default.
- W3122337303 cites W2406106130 @default.
- W3122337303 cites W2512275303 @default.
- W3122337303 cites W2522653422 @default.
- W3122337303 cites W2545425107 @default.
- W3122337303 cites W2577466502 @default.
- W3122337303 cites W2583712449 @default.
- W3122337303 cites W2589256120 @default.
- W3122337303 cites W2595858818 @default.
- W3122337303 cites W2596693961 @default.
- W3122337303 cites W2602416590 @default.
- W3122337303 cites W2603317054 @default.
- W3122337303 cites W2626168880 @default.
- W3122337303 cites W2626888907 @default.
- W3122337303 cites W2730107276 @default.
- W3122337303 cites W2731908664 @default.
- W3122337303 cites W2742353889 @default.
- W3122337303 cites W2766833189 @default.
- W3122337303 cites W2767394258 @default.
- W3122337303 cites W2784236187 @default.
- W3122337303 cites W2790223395 @default.