Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122354936> ?p ?o ?g. }
- W3122354936 abstract "Results from registry studies suggest that harnessing Natural Killer (NK) cell reactivity mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of relapse after allogeneic Hematopoietic Cell Transplantation (HCT). Several competing models have been developed to classify donors as KIR-advantageous or disadvantageous. Basically, these models differ by grouping donors based on distinct KIR-KIR-ligand combinations or by haplotype motif assignment. This study aimed to validate different models for unrelated donor selection for patients with Myelodysplatic Syndromes (MDS) or secondary Acute Myeloid Leukemia (sAML). In a joint retrospective study of the European Society for Blood and Marrow Transplantation (EBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR) registry data from 1704 patients with secondary AML or MDS were analysed. The cohort consisted mainly of older patients (median age 61 years) with high risk disease who had received chemotherapy-based reduced intensity conditioning and anti-thymocyte globulin prior to allogeneic HCT from well-matched unrelated stem cell donors. The impact of the predictors on Overall Survival (OS) and relapse incidence was tested in Cox regression models adjusted for patient age, a modified disease risk index, performance status, donor age, HLA-match, sex-match, CMV-match, conditioning intensity, type of T-cell depletion and graft type. KIR genes were typed using high-resolution amplicon-based next generation sequencing. In univariable and multivariable analyses none of the models predicted OS and the risk of relapse consistently. Our results do not support the hypothesis that optimizing NK-mediated alloreactivity is possible by KIR-genotype informed selection of HLA-matched unrelated donors. However, in the context of allogeneic transplantation, NK-cell biology is complex and only partly understood. KIR-genes are highly diverse and current assignment of haplotype motifs based on the presence or absence of selected KIR genes is over-simplistic. As a consequence, further research is highly warranted and should integrate cutting edge knowledge on KIR genetics, and NK-cell biology into future studies focused on homogeneous groups of patients and treatment modalities." @default.
- W3122354936 created "2021-02-01" @default.
- W3122354936 creator A5001646221 @default.
- W3122354936 creator A5001825877 @default.
- W3122354936 creator A5003531307 @default.
- W3122354936 creator A5004741011 @default.
- W3122354936 creator A5006960828 @default.
- W3122354936 creator A5009079290 @default.
- W3122354936 creator A5010183839 @default.
- W3122354936 creator A5021274228 @default.
- W3122354936 creator A5023466579 @default.
- W3122354936 creator A5027029856 @default.
- W3122354936 creator A5030102793 @default.
- W3122354936 creator A5031390636 @default.
- W3122354936 creator A5050987906 @default.
- W3122354936 creator A5054084140 @default.
- W3122354936 creator A5054208517 @default.
- W3122354936 creator A5060552661 @default.
- W3122354936 creator A5064818358 @default.
- W3122354936 creator A5074712719 @default.
- W3122354936 creator A5075500883 @default.
- W3122354936 creator A5079082437 @default.
- W3122354936 creator A5080827913 @default.
- W3122354936 creator A5082379829 @default.
- W3122354936 date "2021-01-19" @default.
- W3122354936 modified "2023-10-17" @default.
- W3122354936 title "Haplotype Motif-Based Models for KIR-Genotype Informed Selection of Hematopoietic Cell Donors Fail to Predict Outcome of Patients With Myelodysplastic Syndromes or Secondary Acute Myeloid Leukemia" @default.
- W3122354936 cites W1672775443 @default.
- W3122354936 cites W1756638473 @default.
- W3122354936 cites W1919577144 @default.
- W3122354936 cites W1966714873 @default.
- W3122354936 cites W1988262403 @default.
- W3122354936 cites W2007509667 @default.
- W3122354936 cites W2017225287 @default.
- W3122354936 cites W2018492618 @default.
- W3122354936 cites W2044474256 @default.
- W3122354936 cites W2044835282 @default.
- W3122354936 cites W2062581776 @default.
- W3122354936 cites W2064085613 @default.
- W3122354936 cites W2075049419 @default.
- W3122354936 cites W2080826082 @default.
- W3122354936 cites W2087034459 @default.
- W3122354936 cites W2087576224 @default.
- W3122354936 cites W2095603321 @default.
- W3122354936 cites W2108395794 @default.
- W3122354936 cites W2110036277 @default.
- W3122354936 cites W2147068163 @default.
- W3122354936 cites W2152197116 @default.
- W3122354936 cites W2153989399 @default.
- W3122354936 cites W2164296311 @default.
- W3122354936 cites W2165813814 @default.
- W3122354936 cites W2253944138 @default.
- W3122354936 cites W2339658711 @default.
- W3122354936 cites W2476725372 @default.
- W3122354936 cites W2521461373 @default.
- W3122354936 cites W2531875528 @default.
- W3122354936 cites W2535570660 @default.
- W3122354936 cites W2538669048 @default.
- W3122354936 cites W2615393228 @default.
- W3122354936 cites W2620585807 @default.
- W3122354936 cites W2786453908 @default.
- W3122354936 cites W2790461174 @default.
- W3122354936 cites W2896230562 @default.
- W3122354936 cites W2898648224 @default.
- W3122354936 cites W2902024981 @default.
- W3122354936 cites W2925256229 @default.
- W3122354936 cites W2981561147 @default.
- W3122354936 cites W2982488323 @default.
- W3122354936 cites W2985152308 @default.
- W3122354936 cites W2998736574 @default.
- W3122354936 cites W2999721358 @default.
- W3122354936 cites W3004596578 @default.
- W3122354936 cites W3006725260 @default.
- W3122354936 cites W3008199892 @default.
- W3122354936 cites W3011200464 @default.
- W3122354936 doi "https://doi.org/10.3389/fimmu.2020.584520" @default.
- W3122354936 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7851088" @default.
- W3122354936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33542712" @default.
- W3122354936 hasPublicationYear "2021" @default.
- W3122354936 type Work @default.
- W3122354936 sameAs 3122354936 @default.
- W3122354936 citedByCount "6" @default.
- W3122354936 countsByYear W31223549362021 @default.
- W3122354936 countsByYear W31223549362022 @default.
- W3122354936 countsByYear W31223549362023 @default.
- W3122354936 crossrefType "journal-article" @default.
- W3122354936 hasAuthorship W3122354936A5001646221 @default.
- W3122354936 hasAuthorship W3122354936A5001825877 @default.
- W3122354936 hasAuthorship W3122354936A5003531307 @default.
- W3122354936 hasAuthorship W3122354936A5004741011 @default.
- W3122354936 hasAuthorship W3122354936A5006960828 @default.
- W3122354936 hasAuthorship W3122354936A5009079290 @default.
- W3122354936 hasAuthorship W3122354936A5010183839 @default.
- W3122354936 hasAuthorship W3122354936A5021274228 @default.
- W3122354936 hasAuthorship W3122354936A5023466579 @default.
- W3122354936 hasAuthorship W3122354936A5027029856 @default.
- W3122354936 hasAuthorship W3122354936A5030102793 @default.
- W3122354936 hasAuthorship W3122354936A5031390636 @default.
- W3122354936 hasAuthorship W3122354936A5050987906 @default.
- W3122354936 hasAuthorship W3122354936A5054084140 @default.