Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122364103> ?p ?o ?g. }
Showing items 1 to 53 of
53
with 100 items per page.
- W3122364103 abstract "Background: Physiosomatic symptoms are an important part of schizophrenia phenomenology. The aim of this study is to examine the biomarker, neurocognitive and symptomatic correlates of physiosomatic symptoms in schizophrenia. Methods: We recruited 115 schizophrenia patients and 43 healthy controls and measured the Fibromyalgia and Chronic Fatigue Syndrome Rating (FF) scale, schizophrenia symptom dimensions, and the Brief Assessment of Cognition in Schizophrenia. We measured neuro-immune markers including plasma CCL11 (eotaxin), interleukin-(IL)-6, IL-10, Dickkopf protein 1 (DKK1), high mobility group box 1 protein (HMGB1) and endogenous opioid system (EOS) markers including κ-opioid receptor (KOR), µ-opioid receptor (MOR), endomorphin-2 (EM2) and β-endorphin. Results: Patients with an increased FF score display increased ratings of psychosis, hostility, excitement, formal though disorders, psychomotor retardation and negative symptoms as compared with patients with lower FF scores. A large part of the variance in the FF score (55.1%) is explained by the regression on digit sequencing task, token motor task, list learning, IL-10, age (all inversely) and IL-6 (positively). Neural network analysis shows that the top-6 predictors of the FF score are (in descending order): IL-6, HMGB1, education, MOR, KOR and IL-10. We found that 45.1% of the variance in a latent vector extracted from cognitive test scores, schizophrenia symptoms and the FF score was explained by HMGB-1, MOR, EM2, DKK1, and CCL11. Conclusions: FF symptoms are an integral part of the phenome of schizophrenia. Neurotoxic immune and neurodegenerative pathways and to a lesser extent the EOS appear to drive FF symptoms in schizophrenia." @default.
- W3122364103 created "2021-02-01" @default.
- W3122364103 creator A5019872290 @default.
- W3122364103 creator A5075708322 @default.
- W3122364103 creator A5076153881 @default.
- W3122364103 creator A5081924790 @default.
- W3122364103 date "2020-03-29" @default.
- W3122364103 modified "2023-09-27" @default.
- W3122364103 title "Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates" @default.
- W3122364103 doi "https://doi.org/10.20944/preprints202003.0432.v1" @default.
- W3122364103 hasPublicationYear "2020" @default.
- W3122364103 type Work @default.
- W3122364103 sameAs 3122364103 @default.
- W3122364103 citedByCount "0" @default.
- W3122364103 crossrefType "posted-content" @default.
- W3122364103 hasAuthorship W3122364103A5019872290 @default.
- W3122364103 hasAuthorship W3122364103A5075708322 @default.
- W3122364103 hasAuthorship W3122364103A5076153881 @default.
- W3122364103 hasAuthorship W3122364103A5081924790 @default.
- W3122364103 hasBestOaLocation W31223641031 @default.
- W3122364103 hasConcept C118552586 @default.
- W3122364103 hasConcept C126322002 @default.
- W3122364103 hasConcept C15744967 @default.
- W3122364103 hasConcept C2776412080 @default.
- W3122364103 hasConcept C2777831278 @default.
- W3122364103 hasConcept C2779727114 @default.
- W3122364103 hasConcept C2780135775 @default.
- W3122364103 hasConcept C71924100 @default.
- W3122364103 hasConceptScore W3122364103C118552586 @default.
- W3122364103 hasConceptScore W3122364103C126322002 @default.
- W3122364103 hasConceptScore W3122364103C15744967 @default.
- W3122364103 hasConceptScore W3122364103C2776412080 @default.
- W3122364103 hasConceptScore W3122364103C2777831278 @default.
- W3122364103 hasConceptScore W3122364103C2779727114 @default.
- W3122364103 hasConceptScore W3122364103C2780135775 @default.
- W3122364103 hasConceptScore W3122364103C71924100 @default.
- W3122364103 hasLocation W31223641031 @default.
- W3122364103 hasOpenAccess W3122364103 @default.
- W3122364103 hasPrimaryLocation W31223641031 @default.
- W3122364103 hasRelatedWork W11527107 @default.
- W3122364103 hasRelatedWork W11574088 @default.
- W3122364103 hasRelatedWork W13235399 @default.
- W3122364103 hasRelatedWork W2286111 @default.
- W3122364103 hasRelatedWork W2342942 @default.
- W3122364103 hasRelatedWork W264321 @default.
- W3122364103 hasRelatedWork W2657021 @default.
- W3122364103 hasRelatedWork W6564969 @default.
- W3122364103 hasRelatedWork W7918995 @default.
- W3122364103 hasRelatedWork W8634809 @default.
- W3122364103 isParatext "false" @default.
- W3122364103 isRetracted "false" @default.
- W3122364103 magId "3122364103" @default.
- W3122364103 workType "article" @default.