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- W3122402016 abstract "Abstract Gram-negative bacteria take up the essential ion Fe 3+ as ferric-siderophore complexes through their outer membrane using TonB-dependent transporters. However, the subsequent route through the inner membrane differs across many bacterial species and siderophore chemistries and is not understood in detail. Here, we report the crystal structure of the inner membrane protein FoxB (from P. aeruginosa ) that is involved in Fe-siderophore uptake. The structure revealed a novel fold with two tightly-bound heme molecules. In combination with functional studies these results establish FoxB as an inner membrane reductase involved in the release of iron from ferrioxamine during Fe-siderophore uptake." @default.
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- W3122402016 date "2021-01-28" @default.
- W3122402016 modified "2023-09-25" @default.
- W3122402016 title "Structural insights into a novel family of integral membrane siderophore reductases" @default.
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- W3122402016 doi "https://doi.org/10.1101/2021.01.28.428567" @default.
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