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• W3122402886 startingPage "129686" @default.
• W3122402886 abstract "Ion channels on cytoplasmic membrane function to sense various environmental stimuli. We here determined the changes of genes encoding ion channels in Caenorhabditis elegans after exposure to polystyrene nanoparticles (PS-NPs). Exposure to 1–1000 μg/L PS-NPs could increase expressions of egl-19, mec-10, trp-4, trp-2, tax-4, cca-1, unc-2, and unc-93, and decrease the expressions of cng-3, mec-6, ocr-2, deg-1, exc-4, kvs-1, and eat-2. Among these 15 ion channel genes, RNAi knockdown of cng-3 or eat-2 caused resistance to PS-NPs toxicity and RNAi knockdown of egl-19, cca-1, tax-4, or unc-93 induced susceptibility to PS-NPs toxicity, suggesting that cng-3, eat-2, egl-19, cca-1, tax-4, and unc-93 were involved in the control of PS-NPs toxicity. EGL-19 and CCA-1 functioned in intestinal cells to control PS-NPs toxicity, and CNG-3, EAT-2, EGL-19, TAX-4, and UNC-93 functioned in neuronal cells to control PS-NPs. Moreover, in intestinal cells of PS-NPs exposed worms, cca-1 RNAi knockdown decreased elt-2 expression, and egl-19 RNAi knockdown decreased daf-16 and elt-2 expressions. In neuronal cells of PS-NPs exposed worms, eat-2 RNAi knockdown increased jnk-1, mpk-1, and dbl-1 expressions, unc-93 RNAi knockdown decreased mpk-1 and daf-7 expressions, and tax-4 RNAi knockdown decreased jnk-1 and daf-7 expressions. Therefore, two molecular networks mediated by ion channels in intestinal cells and neuronal cells were dysregulated by PS-NPs exposure in C. elegans. Our data suggested that the dysregulation in expressions of these ion channels mediated a protective response to PS-NPs in the range of μg/L in worms." @default.
• W3122402886 created "2021-02-01" @default.
• W3122402886 creator A5008456870 @default.
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• W3122402886 date "2021-06-01" @default.
• W3122402886 modified "2023-10-14" @default.
• W3122402886 title "Alteration in expressions of ion channels in Caenorhabditis elegans exposed to polystyrene nanoparticles" @default.
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• W3122402886 doi "https://doi.org/10.1016/j.chemosphere.2021.129686" @default.
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