FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122468659> ?p ?o ?g. }

• W3122468659 endingPage "2003157" @default.
• W3122468659 startingPage "2003157" @default.
• W3122468659 abstract "Bronchiectasis is a heterogenous disease with multiple underlying causes. The pathophysiology is poorly understood but neutrophilic inflammation and dysfunctional killing of pathogens is believed to be key. There are, however, no licensed therapies for bronchiectasis that directly target neutrophilic inflammation. In this review, we discuss our current understanding of neutrophil dysfunction and therapeutic targeting in bronchiectasis. Immunometabolic reprogramming, a process through which inflammation changes inflammatory cell behaviour by altering intracellular metabolic pathways, is increasingly recognised across multiple inflammatory and autoimmune diseases. Here, we show evidence that much of the neutrophil dysfunction observed in bronchiectasis is consistent with immunometabolic reprogramming. Previous attempts at developing therapies targeting neutrophils have focused on reducing neutrophil numbers, resulting in increased frequency of infections. New approaches are needed and we propose that targeting metabolism could theoretically reverse neutrophil dysfunction and dysregulated inflammation. As an exemplar, 5' adenosine monophosphate (AMP)-activated protein kinase (AMPK) activation has already been shown to reverse phagocytic dysfunction and neutrophil extracellular trap (NET) formation in models of pulmonary disease. AMPK modulates multiple metabolic pathways, including glycolysis which is critical for energy generation in neutrophils. AMPK activators can reverse metabolic reprogramming and are already in clinical use and/or development. We propose the need for a new immunomodulatory approach, rather than an anti-inflammatory approach, to enhance bacterial clearance and reduce bronchiectasis disease severity." @default.
• W3122468659 created "2021-02-01" @default.
• W3122468659 creator A5056681502 @default.
• W3122468659 creator A5067795136 @default.
• W3122468659 creator A5077136855 @default.
• W3122468659 date "2021-01-28" @default.
• W3122468659 modified "2023-09-29" @default.
• W3122468659 title "Neutrophil dysfunction in bronchiectasis: an emerging role for immunometabolism" @default.
• W3122468659 cites W1481437857 @default.
• W3122468659 cites W1484764033 @default.
• W3122468659 cites W1492789649 @default.
• W3122468659 cites W1572925458 @default.
• W3122468659 cites W1637945960 @default.
• W3122468659 cites W1675830194 @default.
• W3122468659 cites W1775421522 @default.
• W3122468659 cites W1839776467 @default.
• W3122468659 cites W1850044168 @default.
• W3122468659 cites W1968739991 @default.
• W3122468659 cites W1972847358 @default.
• W3122468659 cites W1976858537 @default.
• W3122468659 cites W1986282241 @default.
• W3122468659 cites W1987210971 @default.
• W3122468659 cites W1992832263 @default.
• W3122468659 cites W1993491652 @default.
• W3122468659 cites W2003206984 @default.
• W3122468659 cites W2005049163 @default.
• W3122468659 cites W2007150427 @default.
• W3122468659 cites W2013063527 @default.
• W3122468659 cites W2016437170 @default.
• W3122468659 cites W2016535776 @default.
• W3122468659 cites W2019210852 @default.
• W3122468659 cites W2019683289 @default.
• W3122468659 cites W2020022405 @default.
• W3122468659 cites W2022464927 @default.
• W3122468659 cites W2029022410 @default.
• W3122468659 cites W2048992783 @default.
• W3122468659 cites W2056112680 @default.
• W3122468659 cites W2063966020 @default.
• W3122468659 cites W2071483471 @default.
• W3122468659 cites W2071975855 @default.
• W3122468659 cites W2073618371 @default.
• W3122468659 cites W2076002276 @default.
• W3122468659 cites W2077061494 @default.
• W3122468659 cites W2082817623 @default.
• W3122468659 cites W2092130336 @default.
• W3122468659 cites W2097080185 @default.
• W3122468659 cites W2103403666 @default.
• W3122468659 cites W2104893458 @default.
• W3122468659 cites W2104934425 @default.
• W3122468659 cites W2110678596 @default.
• W3122468659 cites W2118472597 @default.
• W3122468659 cites W2125245491 @default.
• W3122468659 cites W2129119043 @default.
• W3122468659 cites W2129224427 @default.
• W3122468659 cites W2135116761 @default.
• W3122468659 cites W2135849676 @default.
• W3122468659 cites W2136324042 @default.
• W3122468659 cites W2142112444 @default.
• W3122468659 cites W2142493853 @default.
• W3122468659 cites W2142537027 @default.
• W3122468659 cites W2144086845 @default.
• W3122468659 cites W2145417168 @default.
• W3122468659 cites W2147876251 @default.
• W3122468659 cites W2151593963 @default.
• W3122468659 cites W2152169346 @default.
• W3122468659 cites W2155915325 @default.
• W3122468659 cites W2160615487 @default.
• W3122468659 cites W2163761940 @default.
• W3122468659 cites W2164304811 @default.
• W3122468659 cites W2165617076 @default.
• W3122468659 cites W2167163732 @default.
• W3122468659 cites W2170716497 @default.
• W3122468659 cites W2174122845 @default.
• W3122468659 cites W2189199225 @default.
• W3122468659 cites W2277332640 @default.
• W3122468659 cites W2462514513 @default.
• W3122468659 cites W2493034509 @default.
• W3122468659 cites W2510362766 @default.
• W3122468659 cites W2516724335 @default.
• W3122468659 cites W2519545824 @default.
• W3122468659 cites W2536165931 @default.
• W3122468659 cites W2549199766 @default.
• W3122468659 cites W2549464601 @default.
• W3122468659 cites W2587278410 @default.
• W3122468659 cites W2614503044 @default.
• W3122468659 cites W2755268241 @default.
• W3122468659 cites W2755344868 @default.
• W3122468659 cites W2775136404 @default.
• W3122468659 cites W2775872756 @default.
• W3122468659 cites W2785943060 @default.
• W3122468659 cites W2790484425 @default.
• W3122468659 cites W2792366526 @default.
• W3122468659 cites W2801014642 @default.
• W3122468659 cites W2808948455 @default.
• W3122468659 cites W2809779343 @default.
• W3122468659 cites W2810427028 @default.
• W3122468659 cites W2884457464 @default.
• W3122468659 cites W2891610856 @default.

• next