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• W3122470240 endingPage "366" @default.
• W3122470240 startingPage "346" @default.
• W3122470240 abstract "The ability of cells to deal with different types of stressful situations in a precise and coordinated manner is key for survival and involves various signalling networks. Over the past 25 years, p38 kinases — in particular, p38α — have been implicated in the cellular response to stress at many levels. These span from environmental and intracellular stresses, such as hyperosmolarity, oxidative stress or DNA damage, to physiological situations that involve important cellular changes such as differentiation. Given that p38α controls a plethora of functions, dysregulation of this pathway has been linked to diseases such as inflammation, immune disorders or cancer, suggesting the possibility that targeting p38α could be of therapeutic interest. In this Review, we discuss the organization of this signalling pathway focusing on the diversity of p38α substrates, their mechanisms and their links to particular cellular functions. We then address how the different cellular responses can be generated depending on the signal received and the cell type, and highlight the roles of this kinase in human physiology and in pathological contexts. p38α — the best-characterized member of the p38 kinase family — is a key mediator of cellular stress responses. p38α is activated by a plethora of signals and functions through a multitude of substrates to regulate different cellular behaviours. Understanding context-dependent p38α signalling provides important insights into p38α roles in physiology and pathology." @default.
• W3122470240 created "2021-02-01" @default.
• W3122470240 creator A5007370352 @default.
• W3122470240 creator A5020217984 @default.
• W3122470240 date "2021-01-27" @default.
• W3122470240 modified "2023-10-18" @default.
• W3122470240 title "Diversity and versatility of p38 kinase signalling in health and disease" @default.
• W3122470240 cites W1486941631 @default.
• W3122470240 cites W1518607321 @default.
• W3122470240 cites W1531617031 @default.
• W3122470240 cites W1556080027 @default.
• W3122470240 cites W1565491355 @default.
• W3122470240 cites W1586300346 @default.
• W3122470240 cites W1751748906 @default.
• W3122470240 cites W1910950086 @default.
• W3122470240 cites W1940455180 @default.
• W3122470240 cites W1965025763 @default.
• W3122470240 cites W1965909642 @default.
• W3122470240 cites W1966008617 @default.
• W3122470240 cites W1967965268 @default.
• W3122470240 cites W1969706233 @default.
• W3122470240 cites W1972169896 @default.
• W3122470240 cites W1972926000 @default.
• W3122470240 cites W1973184170 @default.
• W3122470240 cites W1973766879 @default.
• W3122470240 cites W1974198922 @default.
• W3122470240 cites W1975974673 @default.
• W3122470240 cites W1976462601 @default.
• W3122470240 cites W1978021679 @default.
• W3122470240 cites W1978651414 @default.
• W3122470240 cites W1980926721 @default.
• W3122470240 cites W1982123744 @default.
• W3122470240 cites W1984283949 @default.
• W3122470240 cites W1991962444 @default.
• W3122470240 cites W1997379466 @default.
• W3122470240 cites W2001366460 @default.
• W3122470240 cites W2001399809 @default.
• W3122470240 cites W2003605266 @default.
• W3122470240 cites W2010335651 @default.
• W3122470240 cites W2011312875 @default.
• W3122470240 cites W2014900583 @default.
• W3122470240 cites W2019218097 @default.
• W3122470240 cites W2021116504 @default.
• W3122470240 cites W2021811797 @default.
• W3122470240 cites W2023615805 @default.
• W3122470240 cites W2025395578 @default.
• W3122470240 cites W2026030222 @default.
• W3122470240 cites W2027052842 @default.
• W3122470240 cites W2028582149 @default.
• W3122470240 cites W2028787381 @default.
• W3122470240 cites W2032731042 @default.
• W3122470240 cites W2033427329 @default.
• W3122470240 cites W2033748513 @default.
• W3122470240 cites W2036606290 @default.
• W3122470240 cites W2038472314 @default.
• W3122470240 cites W2039563448 @default.
• W3122470240 cites W2043620856 @default.
• W3122470240 cites W2044256013 @default.
• W3122470240 cites W2047152276 @default.
• W3122470240 cites W2049277771 @default.
• W3122470240 cites W2049651125 @default.
• W3122470240 cites W2052474826 @default.
• W3122470240 cites W2055217118 @default.
• W3122470240 cites W2056907950 @default.
• W3122470240 cites W2065685023 @default.
• W3122470240 cites W2066679153 @default.
• W3122470240 cites W2067832283 @default.
• W3122470240 cites W2067870508 @default.
• W3122470240 cites W2068633034 @default.
• W3122470240 cites W2071645343 @default.
• W3122470240 cites W2073206600 @default.
• W3122470240 cites W2074981365 @default.
• W3122470240 cites W2075420263 @default.
• W3122470240 cites W2078541372 @default.
• W3122470240 cites W2079435750 @default.
• W3122470240 cites W2080732549 @default.
• W3122470240 cites W2081858180 @default.
• W3122470240 cites W2082398895 @default.
• W3122470240 cites W2083960052 @default.
• W3122470240 cites W2084472730 @default.
• W3122470240 cites W2087433596 @default.
• W3122470240 cites W2088086126 @default.
• W3122470240 cites W2088919762 @default.
• W3122470240 cites W2097843267 @default.
• W3122470240 cites W2098697092 @default.
• W3122470240 cites W2104818214 @default.
• W3122470240 cites W2106247097 @default.
• W3122470240 cites W2107961902 @default.
• W3122470240 cites W2109427442 @default.
• W3122470240 cites W2111869518 @default.
• W3122470240 cites W2112135110 @default.
• W3122470240 cites W2112479944 @default.
• W3122470240 cites W2112849045 @default.
• W3122470240 cites W2114173753 @default.
• W3122470240 cites W2115341926 @default.
• W3122470240 cites W2118165248 @default.
• W3122470240 cites W2121000910 @default.
• W3122470240 cites W2121507786 @default.

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