Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122493628> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3122493628 abstract "Abstract Background Loss of CD56 expression has been regarded as a diagnostic marker of papillary thyroid carcinoma (PTC). However, certain variants of PTC can aberrantly express CD56. Methods Using a digital-image analysis tool, we evaluated H-scores of CD56 immunostaining in 216 thyroid tumors. Results The H-score of the CD56 of all PTCs was lower than that of noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) ( p < 0.001). The H-scores of CD56 were lower in classic PTC, the infiltrative follicular variant, and the diffuse sclerosing variant than in other PTC variants ( p < 0.001), whereas the H-scores were higher in tall cell variant, Warthin-like variant, and cribriform-morular variant than in classic PTC ( p < 0.001). The optimal cut-off value of H-scores for the CD56 expression was 180 for differentiating the NIFTP from the follicular adenoma and 30 for the differential diagnosis of NIFTP and infiltrative follicular variant PTC. Conclusions CD56 expression is predominantly lost in classic and infiltrative follicular variants of PTCs and more preserved in the other histologic subtypes of PTC and NIFTP. CD56 is particularly useful for differentiating PTC from follicular-pattern thyroid neoplasms, but the aberrant expression in uncommon variants of PTC could be a diagnostic pitfall." @default.
- W3122493628 created "2021-02-01" @default.
- W3122493628 creator A5033998540 @default.
- W3122493628 creator A5036684599 @default.
- W3122493628 creator A5043744368 @default.
- W3122493628 creator A5086531855 @default.
- W3122493628 date "2020-07-16" @default.
- W3122493628 modified "2023-09-23" @default.
- W3122493628 title "CD56 Expression in Papillary Thyroid Carcinoma is Highly Dependent on the Histologic Subtype: A Potential Diagnostic Pitfall" @default.
- W3122493628 doi "https://doi.org/10.21203/rs.3.rs-42809/v1" @default.
- W3122493628 hasPublicationYear "2020" @default.
- W3122493628 type Work @default.
- W3122493628 sameAs 3122493628 @default.
- W3122493628 citedByCount "0" @default.
- W3122493628 crossrefType "posted-content" @default.
- W3122493628 hasAuthorship W3122493628A5033998540 @default.
- W3122493628 hasAuthorship W3122493628A5036684599 @default.
- W3122493628 hasAuthorship W3122493628A5043744368 @default.
- W3122493628 hasAuthorship W3122493628A5086531855 @default.
- W3122493628 hasBestOaLocation W31224936281 @default.
- W3122493628 hasConcept C126322002 @default.
- W3122493628 hasConcept C142724271 @default.
- W3122493628 hasConcept C187785154 @default.
- W3122493628 hasConcept C204232928 @default.
- W3122493628 hasConcept C2777428134 @default.
- W3122493628 hasConcept C2777802297 @default.
- W3122493628 hasConcept C2778057883 @default.
- W3122493628 hasConcept C2780399592 @default.
- W3122493628 hasConcept C2780801072 @default.
- W3122493628 hasConcept C2993294228 @default.
- W3122493628 hasConcept C4224716 @default.
- W3122493628 hasConcept C526584372 @default.
- W3122493628 hasConcept C71924100 @default.
- W3122493628 hasConceptScore W3122493628C126322002 @default.
- W3122493628 hasConceptScore W3122493628C142724271 @default.
- W3122493628 hasConceptScore W3122493628C187785154 @default.
- W3122493628 hasConceptScore W3122493628C204232928 @default.
- W3122493628 hasConceptScore W3122493628C2777428134 @default.
- W3122493628 hasConceptScore W3122493628C2777802297 @default.
- W3122493628 hasConceptScore W3122493628C2778057883 @default.
- W3122493628 hasConceptScore W3122493628C2780399592 @default.
- W3122493628 hasConceptScore W3122493628C2780801072 @default.
- W3122493628 hasConceptScore W3122493628C2993294228 @default.
- W3122493628 hasConceptScore W3122493628C4224716 @default.
- W3122493628 hasConceptScore W3122493628C526584372 @default.
- W3122493628 hasConceptScore W3122493628C71924100 @default.
- W3122493628 hasLocation W31224936281 @default.
- W3122493628 hasOpenAccess W3122493628 @default.
- W3122493628 hasPrimaryLocation W31224936281 @default.
- W3122493628 hasRelatedWork W1992191048 @default.
- W3122493628 hasRelatedWork W2065139947 @default.
- W3122493628 hasRelatedWork W2104225413 @default.
- W3122493628 hasRelatedWork W2129458135 @default.
- W3122493628 hasRelatedWork W2386065869 @default.
- W3122493628 hasRelatedWork W3024677253 @default.
- W3122493628 hasRelatedWork W4200421397 @default.
- W3122493628 hasRelatedWork W168523925 @default.
- W3122493628 hasRelatedWork W2114773524 @default.
- W3122493628 hasRelatedWork W2604099379 @default.
- W3122493628 isParatext "false" @default.
- W3122493628 isRetracted "false" @default.
- W3122493628 magId "3122493628" @default.
- W3122493628 workType "article" @default.