FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122494604> ?p ?o ?g. }

• W3122494604 endingPage "175883592098652" @default.
• W3122494604 startingPage "175883592098652" @default.
• W3122494604 abstract "Chemotherapy is an established treatment for stage III colon cancer cases. Older age is known to be associated with less chemotherapy use in these patients, but there might be other relevant factors besides age that influence treatment administration. We summarized evidence on associations between comorbidity and adjuvant chemotherapy administration in stage III colon cancer patients in a systematic review and meta-analysis.We searched the PubMed and Web of Science databases up to 2 June 2020 for studies on comorbidities and chemotherapy use in patients with stage III colon cancer. Summary odds ratios (OR) and 95% confidence intervals (95% CI) were estimated using random-effects models. Subgroup analyses according to year of colon cancer diagnosis, timing of comorbidity assessment, and geographical region were also conducted.Thirty-three studies were included in this review, including 219,406 stage III colon cancer patients overall. Chemotherapy administration was 60.9% (95% CI: 56.9% to 64.9%), increasing from 57.1% before 2001 to 66.3% after 2010. There were inverse associations between comorbidities and chemotherapy administration. Compared with patients with Charlson comorbidity score 0, those with scores 1 (OR = 0.79, 95% CI = 0.72-0.87) and 2+ (OR = 0.49, 95% CI = 0.42-0.56) received chemotherapy less often. Among comorbidities, the strongest predictors of chemotherapy non-use were dementia (OR = 0.37, 95% CI = 0.33-0.54), followed by heart failure (OR = 0.44, 95% CI = 0.28-0.70) and stroke (OR = 0.56, 95% CI = 0.38-0.81).Merely 60% of stage III colon cancer patients receive chemotherapy. Comorbidities are strong predictors of chemotherapy non-use, but the association differs by comorbid condition and is strongest with dementia. Given the survival disadvantage of colon cancer patients with comorbidities, further evidence on the risk-benefit ratio of chemotherapy according to the type and severity of comorbidity and on the extent to which the survival disadvantage of comorbidity is explained by less use or lower tolerability of chemotherapy is needed to foster personalized medical care in these patients." @default.
• W3122494604 created "2021-02-01" @default.
• W3122494604 creator A5009305200 @default.
• W3122494604 creator A5027211458 @default.
• W3122494604 creator A5030844189 @default.
• W3122494604 creator A5034447826 @default.
• W3122494604 creator A5073749229 @default.
• W3122494604 date "2021-01-01" @default.
• W3122494604 modified "2023-09-30" @default.
• W3122494604 title "The association of comorbidities with administration of adjuvant chemotherapy in stage III colon cancer patients: a systematic review and meta-analysis" @default.
• W3122494604 cites W1486332874 @default.
• W3122494604 cites W1754767746 @default.
• W3122494604 cites W1844854109 @default.
• W3122494604 cites W1883376635 @default.
• W3122494604 cites W1907437898 @default.
• W3122494604 cites W1944915298 @default.
• W3122494604 cites W1949223619 @default.
• W3122494604 cites W1965566691 @default.
• W3122494604 cites W1979423827 @default.
• W3122494604 cites W1996917977 @default.
• W3122494604 cites W2000445173 @default.
• W3122494604 cites W2000949271 @default.
• W3122494604 cites W2001344066 @default.
• W3122494604 cites W2001728553 @default.
• W3122494604 cites W2017654486 @default.
• W3122494604 cites W2019251171 @default.
• W3122494604 cites W2026468855 @default.
• W3122494604 cites W2032830095 @default.
• W3122494604 cites W2033585778 @default.
• W3122494604 cites W2035843475 @default.
• W3122494604 cites W2036740 @default.
• W3122494604 cites W2041321326 @default.
• W3122494604 cites W2045762430 @default.
• W3122494604 cites W2049564837 @default.
• W3122494604 cites W2079389004 @default.
• W3122494604 cites W2080062875 @default.
• W3122494604 cites W2085717627 @default.
• W3122494604 cites W2085874953 @default.
• W3122494604 cites W2093536899 @default.
• W3122494604 cites W2105707946 @default.
• W3122494604 cites W2107328434 @default.
• W3122494604 cites W2120490314 @default.
• W3122494604 cites W2120871118 @default.
• W3122494604 cites W2126930838 @default.
• W3122494604 cites W2137419492 @default.
• W3122494604 cites W2138309253 @default.
• W3122494604 cites W2138446143 @default.
• W3122494604 cites W2139002359 @default.
• W3122494604 cites W2144495943 @default.
• W3122494604 cites W2145568247 @default.
• W3122494604 cites W2147407874 @default.
• W3122494604 cites W2151273634 @default.
• W3122494604 cites W2158257131 @default.
• W3122494604 cites W2160526175 @default.
• W3122494604 cites W2165943273 @default.
• W3122494604 cites W2171965579 @default.
• W3122494604 cites W2172192209 @default.
• W3122494604 cites W2201595259 @default.
• W3122494604 cites W2232637765 @default.
• W3122494604 cites W2236725094 @default.
• W3122494604 cites W2255713821 @default.
• W3122494604 cites W2588681363 @default.
• W3122494604 cites W2624765161 @default.
• W3122494604 cites W2753690877 @default.
• W3122494604 cites W2760091740 @default.
• W3122494604 cites W2767580164 @default.
• W3122494604 cites W2769979032 @default.
• W3122494604 cites W2794139725 @default.
• W3122494604 cites W2889646458 @default.
• W3122494604 cites W2908722991 @default.
• W3122494604 cites W2962993036 @default.
• W3122494604 cites W2971573599 @default.
• W3122494604 cites W2971940072 @default.
• W3122494604 cites W2982191178 @default.
• W3122494604 cites W2984880947 @default.
• W3122494604 cites W2999013131 @default.
• W3122494604 cites W3000612336 @default.
• W3122494604 cites W3005748206 @default.
• W3122494604 cites W3008244572 @default.
• W3122494604 cites W3022903699 @default.
• W3122494604 doi "https://doi.org/10.1177/1758835920986520" @default.
• W3122494604 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7841869" @default.
• W3122494604 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33613694" @default.
• W3122494604 hasPublicationYear "2021" @default.
• W3122494604 type Work @default.
• W3122494604 sameAs 3122494604 @default.
• W3122494604 citedByCount "5" @default.
• W3122494604 countsByYear W31224946042022 @default.
• W3122494604 countsByYear W31224946042023 @default.
• W3122494604 crossrefType "journal-article" @default.
• W3122494604 hasAuthorship W3122494604A5009305200 @default.
• W3122494604 hasAuthorship W3122494604A5027211458 @default.
• W3122494604 hasAuthorship W3122494604A5030844189 @default.
• W3122494604 hasAuthorship W3122494604A5034447826 @default.
• W3122494604 hasAuthorship W3122494604A5073749229 @default.
• W3122494604 hasBestOaLocation W31224946041 @default.
• W3122494604 hasConcept C121608353 @default.
• W3122494604 hasConcept C126322002 @default.

• next