FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122534496> ?p ?o ?g. }

• W3122534496 endingPage "153" @default.
• W3122534496 startingPage "153" @default.
• W3122534496 abstract "Helicobacter pylori is the main pathogen responsible for gastric ulcers and a predisposing factor of stomach cancer. Although current treatment is usually successful, it requires high doses and frequent administration. An innovative mucoadhesive system (Mucolast®) loaded with amoxicillin and clarithromycin is proposed to improve the efficacy of treatment against H. pylori. The drug product was optimized based on its viscoelastic properties to obtain long-term stability of the vehicle. The drug release mechanisms were different for both antibiotics based on their solubilization status. A systemic and stomach pharmacokinetic profile was obtained after three different doses were administered to mice, obtaining similar systemic exposure levels but an increase in drug concentration in the stomach. The efficacy results in mice infected with H. pylori also demonstrated the superiority of the antibiotics when administered in Mucolast®, as shown by the bacterial count in stomach tissue and under histopathological and biochemical evaluation. The proposed treatment was efficacious and safe and is presented as a realistic alternative to current treatment options to improve patient compliance and to reduce bacterial resistance." @default.
• W3122534496 created "2021-02-01" @default.
• W3122534496 creator A5000838605 @default.
• W3122534496 creator A5001980127 @default.
• W3122534496 creator A5017697687 @default.
• W3122534496 creator A5025451567 @default.
• W3122534496 creator A5038291122 @default.
• W3122534496 creator A5046903926 @default.
• W3122534496 creator A5048414219 @default.
• W3122534496 creator A5062301538 @default.
• W3122534496 creator A5072354102 @default.
• W3122534496 creator A5080568827 @default.
• W3122534496 creator A5087024158 @default.
• W3122534496 creator A5090604935 @default.
• W3122534496 date "2021-01-24" @default.
• W3122534496 modified "2023-10-16" @default.
• W3122534496 title "Amoxicillin and Clarithromycin Mucoadhesive Delivery System for Helicobacter pylori Infection in a Mouse Model: Characterization, Pharmacokinetics, and Efficacy" @default.
• W3122534496 cites W1916026353 @default.
• W3122534496 cites W1963548692 @default.
• W3122534496 cites W1995634417 @default.
• W3122534496 cites W1997667335 @default.
• W3122534496 cites W2024988400 @default.
• W3122534496 cites W2025688642 @default.
• W3122534496 cites W2052307014 @default.
• W3122534496 cites W2053281717 @default.
• W3122534496 cites W2058759666 @default.
• W3122534496 cites W2071699268 @default.
• W3122534496 cites W2091470606 @default.
• W3122534496 cites W2107693575 @default.
• W3122534496 cites W2125030854 @default.
• W3122534496 cites W2129689764 @default.
• W3122534496 cites W2142278204 @default.
• W3122534496 cites W2152472522 @default.
• W3122534496 cites W2153354382 @default.
• W3122534496 cites W2161037139 @default.
• W3122534496 cites W2290466312 @default.
• W3122534496 cites W2333829219 @default.
• W3122534496 cites W2344679815 @default.
• W3122534496 cites W2463078408 @default.
• W3122534496 cites W2570938003 @default.
• W3122534496 cites W2598748979 @default.
• W3122534496 cites W2610458445 @default.
• W3122534496 cites W2618974892 @default.
• W3122534496 cites W2971423383 @default.
• W3122534496 cites W2972299793 @default.
• W3122534496 cites W4293247451 @default.
• W3122534496 cites W801509832 @default.
• W3122534496 doi "https://doi.org/10.3390/pharmaceutics13020153" @default.
• W3122534496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7911155" @default.
• W3122534496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33498958" @default.
• W3122534496 hasPublicationYear "2021" @default.
• W3122534496 type Work @default.
• W3122534496 sameAs 3122534496 @default.
• W3122534496 citedByCount "5" @default.
• W3122534496 countsByYear W31225344962022 @default.
• W3122534496 countsByYear W31225344962023 @default.
• W3122534496 crossrefType "journal-article" @default.
• W3122534496 hasAuthorship W3122534496A5000838605 @default.
• W3122534496 hasAuthorship W3122534496A5001980127 @default.
• W3122534496 hasAuthorship W3122534496A5017697687 @default.
• W3122534496 hasAuthorship W3122534496A5025451567 @default.
• W3122534496 hasAuthorship W3122534496A5038291122 @default.
• W3122534496 hasAuthorship W3122534496A5046903926 @default.
• W3122534496 hasAuthorship W3122534496A5048414219 @default.
• W3122534496 hasAuthorship W3122534496A5062301538 @default.
• W3122534496 hasAuthorship W3122534496A5072354102 @default.
• W3122534496 hasAuthorship W3122534496A5080568827 @default.
• W3122534496 hasAuthorship W3122534496A5087024158 @default.
• W3122534496 hasAuthorship W3122534496A5090604935 @default.
• W3122534496 hasBestOaLocation W31225344961 @default.
• W3122534496 hasConcept C112705442 @default.
• W3122534496 hasConcept C178790620 @default.
• W3122534496 hasConcept C185592680 @default.
• W3122534496 hasConcept C2776409635 @default.
• W3122534496 hasConcept C2776962512 @default.
• W3122534496 hasConcept C2779422922 @default.
• W3122534496 hasConcept C2779708577 @default.
• W3122534496 hasConcept C2779820397 @default.
• W3122534496 hasConcept C2780035454 @default.
• W3122534496 hasConcept C501593827 @default.
• W3122534496 hasConcept C71924100 @default.
• W3122534496 hasConcept C86803240 @default.
• W3122534496 hasConcept C89423630 @default.
• W3122534496 hasConcept C90924648 @default.
• W3122534496 hasConcept C98274493 @default.
• W3122534496 hasConceptScore W3122534496C112705442 @default.
• W3122534496 hasConceptScore W3122534496C178790620 @default.
• W3122534496 hasConceptScore W3122534496C185592680 @default.
• W3122534496 hasConceptScore W3122534496C2776409635 @default.
• W3122534496 hasConceptScore W3122534496C2776962512 @default.
• W3122534496 hasConceptScore W3122534496C2779422922 @default.
• W3122534496 hasConceptScore W3122534496C2779708577 @default.
• W3122534496 hasConceptScore W3122534496C2779820397 @default.
• W3122534496 hasConceptScore W3122534496C2780035454 @default.
• W3122534496 hasConceptScore W3122534496C501593827 @default.
• W3122534496 hasConceptScore W3122534496C71924100 @default.
• W3122534496 hasConceptScore W3122534496C86803240 @default.
• W3122534496 hasConceptScore W3122534496C89423630 @default.

• next