FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122637510> ?p ?o ?g. }

• W3122637510 endingPage "102564" @default.
• W3122637510 startingPage "102564" @default.
• W3122637510 abstract "Despite an expanding literature on brain alterations in patients with longstanding epilepsy, few neuroimaging studies investigate patients with newly diagnosed focal epilepsy (NDfE). Understanding brain network impairments at diagnosis is necessary to elucidate whether or not brain abnormalities are principally due to the chronicity of the disorder and to develop prognostic markers of treatment outcome. Most adults with NDfE do not have MRI-identifiable lesions and the reasons for seizure onset and refractoriness are unknown. We applied structural connectomics to T1-weighted and multi-shell diffusion MRI data with generalized q-sampling image reconstruction using Network Based Statistics (NBS). We scanned 27 patients within an average of 3.7 (SD = 2.9) months of diagnosis and anti-epileptic drug treatment outcomes were collected 24 months after diagnosis. Seven patients were excluded due to lesional NDfE and outcome data was available in 17 patients. Compared to 29 healthy controls, patients with non-lesional NDfE had connectomes with significantly decreased quantitative anisotropy in edges connecting right temporal, frontal and thalamic nodes and increased diffusivity in edges between bilateral temporal, frontal, occipital and parietal nodes. Compared to controls, patients with persistent seizures showed the largest effect size (|d|>=1) for decreased anisotropy in right parietal edges and increased diffusivity in edges between left thalamus and left parietal nodes. Compared to controls, patients who were rendered seizure-free showed the largest effect size for decreased anisotropy in the edge connecting the left thalamus and right temporal nodes and increased diffusivity in edges connecting right frontal nodes. As demonstrated by large effect sizes, connectomes with decreased anisotropy (edge between right frontal and left insular nodes) and increased diffusivity (edge between right thalamus and left parietal nodes) were found in patients with persistent seizures compared to patients who became seizure-free. Patients who had persistent seizures showed larger effect sizes in all network metrics than patients who became seizure-free when compared to each other and compared to controls. Furthermore, patients with focal-to-bilateral tonic-clonic seizures (FBTCS, N = 11) had decreased quantitative anisotropy in a bilateral network involving edges between temporal, parietal and frontal nodes with greater effect sizes than those of patients without FBTCS (N = 9). NBS findings between patients and controls indicated that structural network changes are not necessarily a consequence of longstanding refractory epilepsy and instead are present at the time of diagnosis. Computed effect sizes suggest that there may be structural network MRI-markers of future pharmacoresistance and seizure severity in patients with a new diagnosis of focal epilepsy." @default.
• W3122637510 created "2021-02-01" @default.
• W3122637510 creator A5005069325 @default.
• W3122637510 creator A5005845056 @default.
• W3122637510 creator A5005879437 @default.
• W3122637510 creator A5013928627 @default.
• W3122637510 creator A5020252837 @default.
• W3122637510 creator A5046547913 @default.
• W3122637510 creator A5054679997 @default.
• W3122637510 creator A5067569321 @default.
• W3122637510 creator A5073129399 @default.
• W3122637510 date "2021-01-01" @default.
• W3122637510 modified "2023-10-18" @default.
• W3122637510 title "Altered structural connectome in non-lesional newly diagnosed focal epilepsy: Relation to pharmacoresistance" @default.
• W3122637510 cites W14177003 @default.
• W3122637510 cites W1460493893 @default.
• W3122637510 cites W1521617359 @default.
• W3122637510 cites W1963564002 @default.
• W3122637510 cites W1968549635 @default.
• W3122637510 cites W1974660211 @default.
• W3122637510 cites W1974809694 @default.
• W3122637510 cites W1984453610 @default.
• W3122637510 cites W1996338330 @default.
• W3122637510 cites W1997756115 @default.
• W3122637510 cites W1999890357 @default.
• W3122637510 cites W2004293194 @default.
• W3122637510 cites W2006096283 @default.
• W3122637510 cites W2007581301 @default.
• W3122637510 cites W2011348057 @default.
• W3122637510 cites W2029136586 @default.
• W3122637510 cites W2030400994 @default.
• W3122637510 cites W2045400361 @default.
• W3122637510 cites W2050139929 @default.
• W3122637510 cites W2053533857 @default.
• W3122637510 cites W2057548353 @default.
• W3122637510 cites W2063600541 @default.
• W3122637510 cites W2083442387 @default.
• W3122637510 cites W2087484885 @default.
• W3122637510 cites W2102389632 @default.
• W3122637510 cites W2104098179 @default.
• W3122637510 cites W2109176867 @default.
• W3122637510 cites W2111080098 @default.
• W3122637510 cites W2117987496 @default.
• W3122637510 cites W2120168996 @default.
• W3122637510 cites W2122410839 @default.
• W3122637510 cites W2122547414 @default.
• W3122637510 cites W2126012718 @default.
• W3122637510 cites W2126838454 @default.
• W3122637510 cites W2152801320 @default.
• W3122637510 cites W2156372649 @default.
• W3122637510 cites W2168844688 @default.
• W3122637510 cites W2170480020 @default.
• W3122637510 cites W2404000875 @default.
• W3122637510 cites W2523646773 @default.
• W3122637510 cites W2568698733 @default.
• W3122637510 cites W2700206214 @default.
• W3122637510 cites W2725181137 @default.
• W3122637510 cites W2738640272 @default.
• W3122637510 cites W2766639217 @default.
• W3122637510 cites W2851906854 @default.
• W3122637510 cites W2891995230 @default.
• W3122637510 cites W2903422519 @default.
• W3122637510 cites W2912187093 @default.
• W3122637510 cites W2952927026 @default.
• W3122637510 cites W2967429590 @default.
• W3122637510 cites W2981168846 @default.
• W3122637510 cites W2996696455 @default.
• W3122637510 cites W3000375498 @default.
• W3122637510 cites W3081345152 @default.
• W3122637510 cites W3091524323 @default.
• W3122637510 cites W3122588479 @default.
• W3122637510 cites W581674602 @default.
• W3122637510 doi "https://doi.org/10.1016/j.nicl.2021.102564" @default.
• W3122637510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7841400" @default.
• W3122637510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33508622" @default.
• W3122637510 hasPublicationYear "2021" @default.
• W3122637510 type Work @default.
• W3122637510 sameAs 3122637510 @default.
• W3122637510 citedByCount "10" @default.
• W3122637510 countsByYear W31226375102021 @default.
• W3122637510 countsByYear W31226375102022 @default.
• W3122637510 countsByYear W31226375102023 @default.
• W3122637510 crossrefType "journal-article" @default.
• W3122637510 hasAuthorship W3122637510A5005069325 @default.
• W3122637510 hasAuthorship W3122637510A5005845056 @default.
• W3122637510 hasAuthorship W3122637510A5005879437 @default.
• W3122637510 hasAuthorship W3122637510A5013928627 @default.
• W3122637510 hasAuthorship W3122637510A5020252837 @default.
• W3122637510 hasAuthorship W3122637510A5046547913 @default.
• W3122637510 hasAuthorship W3122637510A5054679997 @default.
• W3122637510 hasAuthorship W3122637510A5067569321 @default.
• W3122637510 hasAuthorship W3122637510A5073129399 @default.
• W3122637510 hasBestOaLocation W31226375101 @default.
• W3122637510 hasConcept C126838900 @default.
• W3122637510 hasConcept C143409427 @default.
• W3122637510 hasConcept C149550507 @default.
• W3122637510 hasConcept C15744967 @default.
• W3122637510 hasConcept C169760540 @default.

• next