Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122681225> ?p ?o ?g. }
- W3122681225 abstract "Upon activation by different transmembrane receptors, the same signaling protein can induce distinct cellular responses. A way to decipher the mechanisms of such pleiotropic signaling activity is to directly manipulate the decision-making activity that supports the selection between distinct cellular responses. We developed an optogenetic probe (optoSRC) to control SRC signaling, an example of a pleiotropic signaling node, and we demonstrated its ability to generate different acto-adhesive structures (lamellipodia or invadosomes) upon distinct spatio-temporal control of SRC kinase activity. The occurrence of each acto-adhesive structure was simply dictated by the dynamics of optoSRC nanoclusters in adhesive sites, which were dependent on the SH3 and Unique domains of the protein. The different decision-making events regulated by optoSRC dynamics induced distinct downstream signaling pathways, which we characterized using time-resolved proteomic and network analyses. Collectively, by manipulating the molecular mobility of SRC kinase activity, these experiments reveal the pleiotropy-encoding mechanism of SRC signaling." @default.
- W3122681225 created "2021-02-01" @default.
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- W3122681225 date "2021-01-15" @default.
- W3122681225 modified "2023-10-16" @default.
- W3122681225 title "Control of SRC molecular dynamics encodes distinct cytoskeletal responses by specifying signaling pathway usage" @default.
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- W3122681225 doi "https://doi.org/10.1242/jcs.254599" @default.
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- W3122681225 hasPublicationYear "2021" @default.
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