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• W3122779413 endingPage "197" @default.
• W3122779413 startingPage "197" @default.
• W3122779413 abstract "During infection with positive-strand RNA viruses, viral RNA synthesis associates with modified intracellular membranes that form unique and captivating structures in the cytoplasm of the infected cell. These viral replication organelles (ROs) play a key role in the replicative cycle of important human pathogens like coronaviruses, enteroviruses, or flaviviruses. From their discovery to date, progress in our understanding of viral ROs has closely followed new developments in electron microscopy (EM). This review gives a chronological account of this progress and an introduction to the different EM techniques that enabled it. With an ample repertoire of imaging modalities, EM is nowadays a versatile technique that provides structural and functional information at a wide range of scales. Together with well-established approaches like electron tomography or labeling methods, we examine more recent developments, such as volume scanning electron microscopy (SEM) and in situ cryotomography, which are only beginning to be applied to the study of viral ROs. We also highlight the first cryotomography analyses of viral ROs, which have led to the discovery of macromolecular complexes that may serve as RO channels that control the export of newly-made viral RNA. These studies are key first steps towards elucidating the macromolecular complexity of viral ROs." @default.
• W3122779413 created "2021-02-01" @default.
• W3122779413 creator A5056969847 @default.
• W3122779413 creator A5068285707 @default.
• W3122779413 date "2021-01-28" @default.
• W3122779413 modified "2023-10-15" @default.
• W3122779413 title "Multiscale Electron Microscopy for the Study of Viral Replication Organelles" @default.
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• W3122779413 doi "https://doi.org/10.3390/v13020197" @default.
• W3122779413 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7912242" @default.

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