Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122781733> ?p ?o ?g. }
- W3122781733 abstract "Abstract Significant advance has been made towards understanding glioblastoma metabolism through global metabolomic profiling. However, hitherto little is known about the role by which altered metabolism plays in driving the aggressive glioma phenotype. We have previously identified hypotaurine as one of the top-ranked metabolites for differentiating low- and high-grade tumors, and that there is also a strong association between the levels of intratumoral hypotaurine and expression of its biosynthetic enzyme, cysteamine (2-aminoethanethiol) dioxygenase (ADO). Using transcription profiling, we further uncovered that the ADO/hypotaurine axis targets CCL20 secretion through activating the NF-κB pathway to drive the self-renewal and maintenance of glioma ‘cancer stem cells’ or glioma cancer stem-like cells. Conversely, abrogating the ADO/hypotaurine axis using CRISPR/Cas9-mediated gene editing limited glioblastoma cell proliferation and self-renewal in vitro and tumor growth in vivo in an orthotopical mouse model, indicating that this metabolic pathway is a potential key therapeutic target. Collectively, our results unveil a targetable metabolic pathway, which contributes to the growth and progression of aggressive high-grade gliomas, as well as a novel predictive marker for glioblastoma diagnosis and therapy." @default.
- W3122781733 created "2021-02-01" @default.
- W3122781733 creator A5000532175 @default.
- W3122781733 creator A5007435834 @default.
- W3122781733 creator A5021675772 @default.
- W3122781733 creator A5024264361 @default.
- W3122781733 creator A5026709102 @default.
- W3122781733 creator A5027835055 @default.
- W3122781733 creator A5058937453 @default.
- W3122781733 creator A5059628106 @default.
- W3122781733 creator A5075004955 @default.
- W3122781733 creator A5079166449 @default.
- W3122781733 date "2021-01-22" @default.
- W3122781733 modified "2023-10-12" @default.
- W3122781733 title "ADO/hypotaurine: a novel metabolic pathway contributing to glioblastoma development" @default.
- W3122781733 cites W1488736137 @default.
- W3122781733 cites W1965880837 @default.
- W3122781733 cites W1973249583 @default.
- W3122781733 cites W1979395366 @default.
- W3122781733 cites W1985931825 @default.
- W3122781733 cites W2001544973 @default.
- W3122781733 cites W2005580328 @default.
- W3122781733 cites W2022461902 @default.
- W3122781733 cites W2023499595 @default.
- W3122781733 cites W2037184235 @default.
- W3122781733 cites W2055475004 @default.
- W3122781733 cites W2064388113 @default.
- W3122781733 cites W2082256264 @default.
- W3122781733 cites W2112319251 @default.
- W3122781733 cites W2113095091 @default.
- W3122781733 cites W2116876842 @default.
- W3122781733 cites W2123509170 @default.
- W3122781733 cites W2134807618 @default.
- W3122781733 cites W2148977460 @default.
- W3122781733 cites W2155317003 @default.
- W3122781733 cites W2177909750 @default.
- W3122781733 cites W2187810519 @default.
- W3122781733 cites W2252688218 @default.
- W3122781733 cites W2272301129 @default.
- W3122781733 cites W2288761256 @default.
- W3122781733 cites W2497583477 @default.
- W3122781733 cites W2586943834 @default.
- W3122781733 cites W2607129810 @default.
- W3122781733 cites W2624776556 @default.
- W3122781733 cites W2746923034 @default.
- W3122781733 cites W2747989497 @default.
- W3122781733 cites W2790342680 @default.
- W3122781733 cites W2791294740 @default.
- W3122781733 cites W2799842393 @default.
- W3122781733 cites W2800136726 @default.
- W3122781733 cites W2884363441 @default.
- W3122781733 cites W2948036155 @default.
- W3122781733 cites W2967332125 @default.
- W3122781733 cites W2976708906 @default.
- W3122781733 doi "https://doi.org/10.1038/s41420-020-00398-5" @default.
- W3122781733 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7822925" @default.
- W3122781733 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33483477" @default.
- W3122781733 hasPublicationYear "2021" @default.
- W3122781733 type Work @default.
- W3122781733 sameAs 3122781733 @default.
- W3122781733 citedByCount "11" @default.
- W3122781733 countsByYear W31227817332021 @default.
- W3122781733 countsByYear W31227817332022 @default.
- W3122781733 countsByYear W31227817332023 @default.
- W3122781733 crossrefType "journal-article" @default.
- W3122781733 hasAuthorship W3122781733A5000532175 @default.
- W3122781733 hasAuthorship W3122781733A5007435834 @default.
- W3122781733 hasAuthorship W3122781733A5021675772 @default.
- W3122781733 hasAuthorship W3122781733A5024264361 @default.
- W3122781733 hasAuthorship W3122781733A5026709102 @default.
- W3122781733 hasAuthorship W3122781733A5027835055 @default.
- W3122781733 hasAuthorship W3122781733A5058937453 @default.
- W3122781733 hasAuthorship W3122781733A5059628106 @default.
- W3122781733 hasAuthorship W3122781733A5075004955 @default.
- W3122781733 hasAuthorship W3122781733A5079166449 @default.
- W3122781733 hasBestOaLocation W31227817331 @default.
- W3122781733 hasConcept C104317684 @default.
- W3122781733 hasConcept C107459253 @default.
- W3122781733 hasConcept C121608353 @default.
- W3122781733 hasConcept C145103041 @default.
- W3122781733 hasConcept C162746124 @default.
- W3122781733 hasConcept C207701140 @default.
- W3122781733 hasConcept C20875687 @default.
- W3122781733 hasConcept C2776853492 @default.
- W3122781733 hasConcept C2778227246 @default.
- W3122781733 hasConcept C2779701627 @default.
- W3122781733 hasConcept C28328180 @default.
- W3122781733 hasConcept C502942594 @default.
- W3122781733 hasConcept C515207424 @default.
- W3122781733 hasConcept C54355233 @default.
- W3122781733 hasConcept C55427017 @default.
- W3122781733 hasConcept C55493867 @default.
- W3122781733 hasConcept C86803240 @default.
- W3122781733 hasConcept C95444343 @default.
- W3122781733 hasConcept C96232424 @default.
- W3122781733 hasConceptScore W3122781733C104317684 @default.
- W3122781733 hasConceptScore W3122781733C107459253 @default.
- W3122781733 hasConceptScore W3122781733C121608353 @default.
- W3122781733 hasConceptScore W3122781733C145103041 @default.
- W3122781733 hasConceptScore W3122781733C162746124 @default.