FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3122808566> ?p ?o ?g. }

• W3122808566 endingPage "256" @default.
• W3122808566 startingPage "248" @default.
• W3122808566 abstract "Sesamin, a lignan compound, exhibits a variety of biological activities and possesses potent anticancer properties on some human cancers. However, its effect on human colorectal cancer (CRC) remains to be elucidated. To investigate the effects of sesamin on CRC cells and further to explore the mechanisms, cell viability, cell cycle and apoptosis assays were performed in this study. We found that sesamin had a selective antiproliferation of CRC cell line HCT116 in a dose- and time-dependent manner, but no obvious effect on human normal colorectal mucosa epithelial cell FHC. Further study showed that sesamin-induced cell cycle arrest and decreased the expression of Cyclin D1 significantly and dose-dependently in HCT116 cells. Moreover, sesamin dose-dependently triggered apoptosis of HCT116 but not FHC, and promoted the expression levels of proapoptotic biomarkers Bax, cleaved caspase-3 and cleaved PARP-1 and inhibited the expression of antiapoptotic biomarker Bcl-2. Western blot analysis was used to reveal the possible signaling pathways, and we found that sesamin upregulated the phosphorylation expression levels of C-Jun N-terminal kinase (JNK) and p38 except ERK1/2 in a dose-dependent way in both HCT116 and another CRC cell line SW480. Moreover, we found that the apoptosis effect induced by sesamin was partially eliminated by inhibiting JNK or p38 activation. Finally, we showed that sesamin effectively reduced the growth of xenograft tumors derived from cell lines with limited toxicity. Taken together, the potential ability of sesamin to induce cell cycle arrest and apoptosis was shown to be via the p38 and JNK mitogen-activated protein kinase signaling pathways, which may be one of the mechanisms of the anticancer activity of this low-toxic agent." @default.
• W3122808566 created "2021-02-01" @default.
• W3122808566 creator A5013775207 @default.
• W3122808566 creator A5021425239 @default.
• W3122808566 creator A5042832788 @default.
• W3122808566 creator A5050531966 @default.
• W3122808566 creator A5082647510 @default.
• W3122808566 date "2021-01-12" @default.
• W3122808566 modified "2023-09-23" @default.
• W3122808566 title "Sesamin induces cell cycle arrest and apoptosis through p38/C-Jun N-terminal kinase mitogen-activated protein kinase pathways in human colorectal cancer cells" @default.
• W3122808566 cites W1723167028 @default.
• W3122808566 cites W1987118642 @default.
• W3122808566 cites W1989014501 @default.
• W3122808566 cites W2009818284 @default.
• W3122808566 cites W2024501017 @default.
• W3122808566 cites W2034225929 @default.
• W3122808566 cites W2079719065 @default.
• W3122808566 cites W2094222260 @default.
• W3122808566 cites W2096306846 @default.
• W3122808566 cites W2105967610 @default.
• W3122808566 cites W2127430555 @default.
• W3122808566 cites W2271878625 @default.
• W3122808566 cites W2472904797 @default.
• W3122808566 cites W2517410953 @default.
• W3122808566 cites W2524512695 @default.
• W3122808566 cites W2527438532 @default.
• W3122808566 cites W2594373254 @default.
• W3122808566 cites W2603538925 @default.
• W3122808566 cites W2658062003 @default.
• W3122808566 cites W2743345618 @default.
• W3122808566 cites W2753081215 @default.
• W3122808566 cites W2761477807 @default.
• W3122808566 cites W2766580429 @default.
• W3122808566 cites W2774184692 @default.
• W3122808566 cites W2781525129 @default.
• W3122808566 cites W2797956345 @default.
• W3122808566 cites W2889646458 @default.
• W3122808566 cites W2900112088 @default.
• W3122808566 cites W2903370754 @default.
• W3122808566 cites W2928460068 @default.
• W3122808566 cites W2933011443 @default.
• W3122808566 cites W2936756322 @default.
• W3122808566 cites W2946246240 @default.
• W3122808566 cites W2969669738 @default.
• W3122808566 cites W2979772556 @default.
• W3122808566 cites W2993816401 @default.
• W3122808566 cites W3003697872 @default.
• W3122808566 cites W3003754048 @default.
• W3122808566 cites W4211133582 @default.
• W3122808566 doi "https://doi.org/10.1097/cad.0000000000001031" @default.
• W3122808566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33534411" @default.
• W3122808566 hasPublicationYear "2021" @default.
• W3122808566 type Work @default.
• W3122808566 sameAs 3122808566 @default.
• W3122808566 citedByCount "3" @default.
• W3122808566 countsByYear W31228085662021 @default.
• W3122808566 countsByYear W31228085662022 @default.
• W3122808566 crossrefType "journal-article" @default.
• W3122808566 hasAuthorship W3122808566A5013775207 @default.
• W3122808566 hasAuthorship W3122808566A5021425239 @default.
• W3122808566 hasAuthorship W3122808566A5042832788 @default.
• W3122808566 hasAuthorship W3122808566A5050531966 @default.
• W3122808566 hasAuthorship W3122808566A5082647510 @default.
• W3122808566 hasConcept C105696609 @default.
• W3122808566 hasConcept C184235292 @default.
• W3122808566 hasConcept C185592680 @default.
• W3122808566 hasConcept C190283241 @default.
• W3122808566 hasConcept C2776513503 @default.
• W3122808566 hasConcept C29537977 @default.
• W3122808566 hasConcept C31903555 @default.
• W3122808566 hasConcept C502942594 @default.
• W3122808566 hasConcept C51551487 @default.
• W3122808566 hasConcept C55493867 @default.
• W3122808566 hasConcept C62112901 @default.
• W3122808566 hasConcept C86803240 @default.
• W3122808566 hasConcept C95444343 @default.
• W3122808566 hasConcept C97029542 @default.
• W3122808566 hasConceptScore W3122808566C105696609 @default.
• W3122808566 hasConceptScore W3122808566C184235292 @default.
• W3122808566 hasConceptScore W3122808566C185592680 @default.
• W3122808566 hasConceptScore W3122808566C190283241 @default.
• W3122808566 hasConceptScore W3122808566C2776513503 @default.
• W3122808566 hasConceptScore W3122808566C29537977 @default.
• W3122808566 hasConceptScore W3122808566C31903555 @default.
• W3122808566 hasConceptScore W3122808566C502942594 @default.
• W3122808566 hasConceptScore W3122808566C51551487 @default.
• W3122808566 hasConceptScore W3122808566C55493867 @default.
• W3122808566 hasConceptScore W3122808566C62112901 @default.
• W3122808566 hasConceptScore W3122808566C86803240 @default.
• W3122808566 hasConceptScore W3122808566C95444343 @default.
• W3122808566 hasConceptScore W3122808566C97029542 @default.
• W3122808566 hasIssue "3" @default.
• W3122808566 hasLocation W31228085661 @default.
• W3122808566 hasLocation W31228085662 @default.
• W3122808566 hasOpenAccess W3122808566 @default.
• W3122808566 hasPrimaryLocation W31228085661 @default.
• W3122808566 hasRelatedWork W2147266699 @default.
• W3122808566 hasRelatedWork W2350169822 @default.

• next